The Regulation and Immune Signature of Retrotransposons in Cancer
<p dir="ltr">Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes’ activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechan...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2023
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513560020779008 |
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| author | Maisa I. Alkailani (15070764) |
| author2 | Derrick Gibbings (17019075) |
| author2_role | author |
| author_facet | Maisa I. Alkailani (15070764) Derrick Gibbings (17019075) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maisa I. Alkailani (15070764) Derrick Gibbings (17019075) |
| dc.date.none.fl_str_mv | 2023-08-30T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers15174340 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Regulation_and_Immune_Signature_of_Retrotransposons_in_Cancer/24174204 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis transposable elements mobile genome insertions tumorigenesis immunity type I IFN jumping genes |
| dc.title.none.fl_str_mv | The Regulation and Immune Signature of Retrotransposons in Cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes’ activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN responses. Although accumulated evidence suggests that retrotransposons can induce inflammation, the research investigating the exact mechanism of triggering these responses is ongoing. Understanding these mechanisms could improve the therapeutic management of cancer through the use of retrotransposon-induced inflammation as a tool to instigate immune responses to tumors.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15174340" target="_blank">https://dx.doi.org/10.3390/cancers15174340</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_13483eacd871f52eacedea354a47fa8a |
| identifier_str_mv | 10.3390/cancers15174340 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24174204 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Regulation and Immune Signature of Retrotransposons in CancerMaisa I. Alkailani (15070764)Derrick Gibbings (17019075)Biomedical and clinical sciencesOncology and carcinogenesistransposable elementsmobile genomeinsertionstumorigenesisimmunitytype I IFNjumping genes<p dir="ltr">Advances in sequencing technologies and the bioinformatic analysis of big data facilitate the study of jumping genes’ activity in the human genome in cancer from a broad perspective. Retrotransposons, which move from one genomic site to another by a copy-and-paste mechanism, are regulated by various molecular pathways that may be disrupted during tumorigenesis. Active retrotransposons can stimulate type I IFN responses. Although accumulated evidence suggests that retrotransposons can induce inflammation, the research investigating the exact mechanism of triggering these responses is ongoing. Understanding these mechanisms could improve the therapeutic management of cancer through the use of retrotransposon-induced inflammation as a tool to instigate immune responses to tumors.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancers<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15174340" target="_blank">https://dx.doi.org/10.3390/cancers15174340</a></p>2023-08-30T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers15174340https://figshare.com/articles/journal_contribution/The_Regulation_and_Immune_Signature_of_Retrotransposons_in_Cancer/24174204CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/241742042023-08-30T00:00:00Z |
| spellingShingle | The Regulation and Immune Signature of Retrotransposons in Cancer Maisa I. Alkailani (15070764) Biomedical and clinical sciences Oncology and carcinogenesis transposable elements mobile genome insertions tumorigenesis immunity type I IFN jumping genes |
| status_str | publishedVersion |
| title | The Regulation and Immune Signature of Retrotransposons in Cancer |
| title_full | The Regulation and Immune Signature of Retrotransposons in Cancer |
| title_fullStr | The Regulation and Immune Signature of Retrotransposons in Cancer |
| title_full_unstemmed | The Regulation and Immune Signature of Retrotransposons in Cancer |
| title_short | The Regulation and Immune Signature of Retrotransposons in Cancer |
| title_sort | The Regulation and Immune Signature of Retrotransposons in Cancer |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis transposable elements mobile genome insertions tumorigenesis immunity type I IFN jumping genes |