Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism

Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism

<h3>Objectives</h3><p dir="ltr">A previous pilot study showed that pravastatin supplementation improved pregnancy outcomes in women with obstetric antiphospholipid syndrome (OAPS) that developed placental insufficiency despite standard of care treatment low molecular weig...

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Bibliographic Details
Main Author: Eleftheria Lefkou (17052414) (author)
Other Authors: Katerina Varoudi (17093032) (author), Joaquim Pombo (540952) (author), Aleksandar Jurisic (17052408) (author), Zaklina Jurisic (17052411) (author), Greg Contento (8267055) (author), Guillermina Girardi (340464) (author)
Published: 2020
Subjects:
Biomedical and clinical sciences
Pharmacology and pharmaceutical sciences
Reproductive medicine
Antiphospholipid syndrome
Pregnancy
Placental insufficiency
Preeclampsia
Intrauterine growth restriction
Uterine arteries Dopplers
Low molecular weight heparin
Low dose aspirin
Pravastatin
Wire myography
Mouse model
Nitric oxide synthetase
Nitric oxide
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