Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions
<p dir="ltr">Maternal and neonatal health (women during pregnancy, childbirth, and the postnatal period) presents a spectrum of healthcare challenges, including preterm birth, preeclampsia, intrauterine growth restriction, polycystic ovarian syndrome, and gestational diabetes mellitu...
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2025
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| _version_ | 1864513537471152128 |
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| author | Razan Elkahlout (22392133) |
| author2 | Sawsan G. A. A. Mohammed (19325620) Ahmed Najjar (22392136) Thomas Farrell (3933833) Hilal Al Rifai (11619468) Nader Al‐Dewik (14777014) M. Walid Qoronfleh (14153088) |
| author2_role | author author author author author author |
| author_facet | Razan Elkahlout (22392133) Sawsan G. A. A. Mohammed (19325620) Ahmed Najjar (22392136) Thomas Farrell (3933833) Hilal Al Rifai (11619468) Nader Al‐Dewik (14777014) M. Walid Qoronfleh (14153088) |
| author_role | author |
| dc.creator.none.fl_str_mv | Razan Elkahlout (22392133) Sawsan G. A. A. Mohammed (19325620) Ahmed Najjar (22392136) Thomas Farrell (3933833) Hilal Al Rifai (11619468) Nader Al‐Dewik (14777014) M. Walid Qoronfleh (14153088) |
| dc.date.none.fl_str_mv | 2025-03-24T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/prca.70004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Application_of_Proteomics_in_Maternal_and_Neonatal_Health_Advancements_and_Future_Directions/30306118 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Paediatrics Reproductive medicine Health sciences Health services and systems AI biomarker discovery biomarkers clinical validation ethnic populations maternal health neonatal health preterm birth proteomics racial disparity |
| dc.title.none.fl_str_mv | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Maternal and neonatal health (women during pregnancy, childbirth, and the postnatal period) presents a spectrum of healthcare challenges, including preterm birth, preeclampsia, intrauterine growth restriction, polycystic ovarian syndrome, and gestational diabetes mellitus. While genomic investigations have shed light on many of these topics, protein biomarker discovery, a pivotal aspect of such research, holds promise in offering insights into disease diagnosis, progression, and prognosis. This review paper aims to explore the landscape of proteomics research pertaining to the aforementioned disorders. In the search for viable biomarkers, existing ones are either outdated or lack specificity and new ones being investigated do not commonly make it to the validation stage. In this review, the reasons for the gap between the biomarker discovery stage and the clinical validation stage are evaluated, in addition to what steps are being taken to mitigate the unexpectedly slow scientific and clinical progress. Notably, this paper also delves into the ethnic disparities found in maternal and neonatal health research, as well as how AI is currently being used to alleviate socioeconomic and ethnic disparities, as well as its advantages for the analysis of large “omics” datasets. We anticipate this investigation will provide critical, invaluable information for researchers, medical professionals, and policy decision‐makers in this field to improve overall maternal and neonatal health outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: PROTEOMICS – Clinical Applications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/prca.70004" target="_blank">https://dx.doi.org/10.1002/prca.70004</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_150448002e0f1f7efd899c548cc85b6d |
| identifier_str_mv | 10.1002/prca.70004 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30306118 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future DirectionsRazan Elkahlout (22392133)Sawsan G. A. A. Mohammed (19325620)Ahmed Najjar (22392136)Thomas Farrell (3933833)Hilal Al Rifai (11619468)Nader Al‐Dewik (14777014)M. Walid Qoronfleh (14153088)Biological sciencesGeneticsBiomedical and clinical sciencesPaediatricsReproductive medicineHealth sciencesHealth services and systemsAIbiomarker discoverybiomarkersclinical validationethnic populationsmaternal healthneonatal healthpreterm birthproteomicsracial disparity<p dir="ltr">Maternal and neonatal health (women during pregnancy, childbirth, and the postnatal period) presents a spectrum of healthcare challenges, including preterm birth, preeclampsia, intrauterine growth restriction, polycystic ovarian syndrome, and gestational diabetes mellitus. While genomic investigations have shed light on many of these topics, protein biomarker discovery, a pivotal aspect of such research, holds promise in offering insights into disease diagnosis, progression, and prognosis. This review paper aims to explore the landscape of proteomics research pertaining to the aforementioned disorders. In the search for viable biomarkers, existing ones are either outdated or lack specificity and new ones being investigated do not commonly make it to the validation stage. In this review, the reasons for the gap between the biomarker discovery stage and the clinical validation stage are evaluated, in addition to what steps are being taken to mitigate the unexpectedly slow scientific and clinical progress. Notably, this paper also delves into the ethnic disparities found in maternal and neonatal health research, as well as how AI is currently being used to alleviate socioeconomic and ethnic disparities, as well as its advantages for the analysis of large “omics” datasets. We anticipate this investigation will provide critical, invaluable information for researchers, medical professionals, and policy decision‐makers in this field to improve overall maternal and neonatal health outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: PROTEOMICS – Clinical Applications<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/prca.70004" target="_blank">https://dx.doi.org/10.1002/prca.70004</a></p>2025-03-24T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/prca.70004https://figshare.com/articles/journal_contribution/Application_of_Proteomics_in_Maternal_and_Neonatal_Health_Advancements_and_Future_Directions/30306118CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/303061182025-03-24T09:00:00Z |
| spellingShingle | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions Razan Elkahlout (22392133) Biological sciences Genetics Biomedical and clinical sciences Paediatrics Reproductive medicine Health sciences Health services and systems AI biomarker discovery biomarkers clinical validation ethnic populations maternal health neonatal health preterm birth proteomics racial disparity |
| status_str | publishedVersion |
| title | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| title_full | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| title_fullStr | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| title_full_unstemmed | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| title_short | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| title_sort | Application of Proteomics in Maternal and Neonatal Health: Advancements and Future Directions |
| topic | Biological sciences Genetics Biomedical and clinical sciences Paediatrics Reproductive medicine Health sciences Health services and systems AI biomarker discovery biomarkers clinical validation ethnic populations maternal health neonatal health preterm birth proteomics racial disparity |