Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

<h3>Background</h3><p dir="ltr">Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity ar...

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Bibliographic Details
Main Author: Anika Liu (8411805) (author)
Other Authors: Moritz Walter (10001555) (author), Peter Wright (699130) (author), Aleksandra Bartosik (10001558) (author), Daniela Dolciami (1701346) (author), Abdurrahman Elbasir (9977355) (author), Hongbin Yang (2189392) (author), Andreas Bender (192334) (author)
Published: 2021
Subjects:
Chemical sciences
Medicinal and biomolecular chemistry
Drug-induced liver injury (DILI)
Mechanistic models
Structural alerts
Protein target
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