Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2
<p dir="ltr">FOXA2 is a transcription factor, playing an important role during development. We established an induced pluripotent stem cell (iPSC) line, QBRIi009-A, using non-integrating Sendai virus from a 4-year-old boy, displaying a complex clinical phenotype. Molecular karyotypin...
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2020
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| _version_ | 1864513554468569088 |
|---|---|
| author | Ahmed K. Elsayed (13275302) |
| author2 | Maryam Aghadi (17128819) Gowher Ali (14152593) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| author2_role | author author author author author |
| author_facet | Ahmed K. Elsayed (13275302) Maryam Aghadi (17128819) Gowher Ali (14152593) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ahmed K. Elsayed (13275302) Maryam Aghadi (17128819) Gowher Ali (14152593) Sara Al-Khawaga (4792761) Khalid Hussain (110443) Essam M. Abdelalim (5768072) |
| dc.date.none.fl_str_mv | 2020-01-21T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.scr.2020.101705 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Generation_of_a_human_induced_pluripotent_stem_cell_line_QBRIi009-A_from_a_patient_with_a_heterozygous_deletion_of_FOXA2/24287998 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology FOXA2 stem cell line QBRIi009-A transcription factor Diabetes Research Center (QBRI) |
| dc.title.none.fl_str_mv | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">FOXA2 is a transcription factor, playing an important role during development. We established an induced pluripotent stem cell (iPSC) line, QBRIi009-A, using non-integrating Sendai virus from a 4-year-old boy, displaying a complex clinical phenotype. Molecular karyotyping and cytogenetics confirmed a <i>de novo</i> proximal 20p11.2 deletion with a reciprocal translocation between the short arm of chromosome 6 and 20. The deleted region (~969 kb) contains only one gene, <i>FOXA2</i>. The generated hiPSC line was fully characterized for its pluripotency and its genetic identity. This iPSC line provides a useful model to study FOXA2 role during human development and in disease pathogenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2020.101705" target="_blank">https://dx.doi.org/10.1016/j.scr.2020.101705</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_16122d7dbaac2c3b890c74770e10a40f |
| identifier_str_mv | 10.1016/j.scr.2020.101705 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24287998 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2Ahmed K. Elsayed (13275302)Maryam Aghadi (17128819)Gowher Ali (14152593)Sara Al-Khawaga (4792761)Khalid Hussain (110443)Essam M. Abdelalim (5768072)Biological sciencesBiochemistry and cell biologyFOXA2stem cell lineQBRIi009-Atranscription factorDiabetes Research Center (QBRI)<p dir="ltr">FOXA2 is a transcription factor, playing an important role during development. We established an induced pluripotent stem cell (iPSC) line, QBRIi009-A, using non-integrating Sendai virus from a 4-year-old boy, displaying a complex clinical phenotype. Molecular karyotyping and cytogenetics confirmed a <i>de novo</i> proximal 20p11.2 deletion with a reciprocal translocation between the short arm of chromosome 6 and 20. The deleted region (~969 kb) contains only one gene, <i>FOXA2</i>. The generated hiPSC line was fully characterized for its pluripotency and its genetic identity. This iPSC line provides a useful model to study FOXA2 role during human development and in disease pathogenesis.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cell Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.scr.2020.101705" target="_blank">https://dx.doi.org/10.1016/j.scr.2020.101705</a></p>2020-01-21T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.scr.2020.101705https://figshare.com/articles/journal_contribution/Generation_of_a_human_induced_pluripotent_stem_cell_line_QBRIi009-A_from_a_patient_with_a_heterozygous_deletion_of_FOXA2/24287998CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242879982020-01-21T00:00:00Z |
| spellingShingle | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 Ahmed K. Elsayed (13275302) Biological sciences Biochemistry and cell biology FOXA2 stem cell line QBRIi009-A transcription factor Diabetes Research Center (QBRI) |
| status_str | publishedVersion |
| title | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| title_full | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| title_fullStr | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| title_full_unstemmed | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| title_short | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| title_sort | Generation of a human induced pluripotent stem cell line (QBRIi009-A) from a patient with a heterozygous deletion of FOXA2 |
| topic | Biological sciences Biochemistry and cell biology FOXA2 stem cell line QBRIi009-A transcription factor Diabetes Research Center (QBRI) |