A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes

<h3>Purpose</h3><p dir="ltr">Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency; however, the extent to which immune signaling and host defense are impaired is unclear. We assessed the fun...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Andrea Guennoun (2632468) (author)
مؤلفون آخرون:	Salim Bougarn (413372) (author), Taushif Khan (691254) (author), Rafah Mackeh (14151225) (author), Mahbuba Rahman (198499) (author), Fatima Al-Ali (14151237) (author), Manar Ata (9046473) (author), Waleed Aamer (14056969) (author), Debra Prosser (14151240) (author), Tanwir Habib (47644) (author), Evonne Chin-Smith (14151243) (author), Khawla Al-Darwish (14151246) (author), Qian Zhang (49333) (author), Alya Al-Shakaki (3158886) (author), Amal Robay (3158892) (author), Ronald G. Crystal (8813645) (author), Khalid Fakhro (3441305) (author), Amal Al-Naimi (14151249) (author), Eman Al Maslamani (14151252) (author), Amjad Tuffaha (13040260) (author), Ibrahim Janahi (3744933) (author), Mohammad Janahi (14151255) (author), Donald R. Love (14151258) (author), Mohammed Yousuf Karim (8602092) (author), Bernice Lo (3441317) (author), Amel Hassan (14151231) (author), Mehdi Adeli (11855663) (author), Nico Marr (349853) (author)
منشور في:	2021
الموضوعات:	Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Human serine/threonine kinase 4 (STK4) deficiency Combined immunodeficiency T cell lymphopenia Interferon Antibody repertoire Transcriptomics
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A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes

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