A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes

A Novel STK4 Mutation Impairs T Cell Immunity Through Dysregulation of Cytokine-Induced Adhesion and Chemotaxis Genes

<h3>Purpose</h3><p dir="ltr">Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency; however, the extent to which immune signaling and host defense are impaired is unclear. We assessed the fun...

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Main Author: Andrea Guennoun (2632468) (author)
Other Authors: Salim Bougarn (413372) (author), Taushif Khan (691254) (author), Rafah Mackeh (14151225) (author), Mahbuba Rahman (198499) (author), Fatima Al-Ali (14151237) (author), Manar Ata (9046473) (author), Waleed Aamer (14056969) (author), Debra Prosser (14151240) (author), Tanwir Habib (47644) (author), Evonne Chin-Smith (14151243) (author), Khawla Al-Darwish (14151246) (author), Qian Zhang (49333) (author), Alya Al-Shakaki (3158886) (author), Amal Robay (3158892) (author), Ronald G. Crystal (8813645) (author), Khalid Fakhro (3441305) (author), Amal Al-Naimi (14151249) (author), Eman Al Maslamani (14151252) (author), Amjad Tuffaha (13040260) (author), Ibrahim Janahi (3744933) (author), Mohammad Janahi (14151255) (author), Donald R. Love (14151258) (author), Mohammed Yousuf Karim (8602092) (author), Bernice Lo (3441317) (author), Amel Hassan (14151231) (author), Mehdi Adeli (11855663) (author), Nico Marr (349853) (author)
Published: 2021
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Clinical sciences
Immunology
Human serine/threonine kinase 4 (STK4) deficiency
Combined immunodeficiency
T cell lymphopenia
Interferon
Antibody repertoire
Transcriptomics
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