Immunoglobulin abnormalities are frequent in patients with lupus nephritis
<p>Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with underlying and induced immune abnormalities, several societies recommend assessing imm...
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513566542921728 |
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| author | M. J. Cuadrado (14153439) |
| author2 | I. Calatayud (14153442) M. Urquizu-Padilla (14153445) S. Wijetilleka (14153448) S. Kiani-Alikhan (14153451) M. Y. Karim (14153454) |
| author2_role | author author author author author |
| author_facet | M. J. Cuadrado (14153439) I. Calatayud (14153442) M. Urquizu-Padilla (14153445) S. Wijetilleka (14153448) S. Kiani-Alikhan (14153451) M. Y. Karim (14153454) |
| author_role | author |
| dc.creator.none.fl_str_mv | M. J. Cuadrado (14153439) I. Calatayud (14153442) M. Urquizu-Padilla (14153445) S. Wijetilleka (14153448) S. Kiani-Alikhan (14153451) M. Y. Karim (14153454) |
| dc.date.none.fl_str_mv | 2021-08-21T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s41927-019-0079-2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Immunoglobulin_abnormalities_are_frequent_in_patients_with_lupus_nephritis/21598551 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Immunoglobulins SLE Lupus nephritis Hypogammaglobulinemia Rituximab Autoimmune B-cells |
| dc.title.none.fl_str_mv | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with underlying and induced immune abnormalities, several societies recommend assessing immune function before and during rituximab treatment. In SLE, polyclonal hypergammaglobulinemia is the typical alteration of gammaglobulins, though hypogammaglobulinemia has also been reported. This is a cross-sectional study describing immunoglobulin levels measured as part of routine care in patients with lupus nephritis, a group with multiple factors contributing to immunoglobulin abnormalities, including immune dysregulation, immunosuppression and nephrotic syndrome. Polyclonal hypergammaglobulinemia occurred in 15/83 (18.1%) patients. In contrast, low levels of immunoglobulins were found as follows: selective IgA deficiency 2/83 (2.4%), reduced IgG levels 7/83 (8.4%), reduced IgM 14/83 (16.9%). Only 1 patient required immunoglobulin replacement. Immunoglobulin abnormalities are frequently found in lupus nephritis, ranging from polyclonal hypergammaglobulinemia to hypogammglobulinemia. Consequently, immunoglobulin levels should be assessed prior to commencing BCTT.</p><h2>Other Information</h2> <p> Published in: BMC Rheumatology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s41927-019-0079-2" target="_blank">http://dx.doi.org/10.1186/s41927-019-0079-2</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_179046aac29464f30c5000a806afa35a |
| identifier_str_mv | 10.1186/s41927-019-0079-2 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598551 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Immunoglobulin abnormalities are frequent in patients with lupus nephritisM. J. Cuadrado (14153439)I. Calatayud (14153442)M. Urquizu-Padilla (14153445)S. Wijetilleka (14153448)S. Kiani-Alikhan (14153451)M. Y. Karim (14153454)Biomedical and clinical sciencesClinical sciencesImmunologyImmunoglobulinsSLELupus nephritisHypogammaglobulinemiaRituximabAutoimmuneB-cells<p>Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with underlying and induced immune abnormalities, several societies recommend assessing immune function before and during rituximab treatment. In SLE, polyclonal hypergammaglobulinemia is the typical alteration of gammaglobulins, though hypogammaglobulinemia has also been reported. This is a cross-sectional study describing immunoglobulin levels measured as part of routine care in patients with lupus nephritis, a group with multiple factors contributing to immunoglobulin abnormalities, including immune dysregulation, immunosuppression and nephrotic syndrome. Polyclonal hypergammaglobulinemia occurred in 15/83 (18.1%) patients. In contrast, low levels of immunoglobulins were found as follows: selective IgA deficiency 2/83 (2.4%), reduced IgG levels 7/83 (8.4%), reduced IgM 14/83 (16.9%). Only 1 patient required immunoglobulin replacement. Immunoglobulin abnormalities are frequently found in lupus nephritis, ranging from polyclonal hypergammaglobulinemia to hypogammglobulinemia. Consequently, immunoglobulin levels should be assessed prior to commencing BCTT.</p><h2>Other Information</h2> <p> Published in: BMC Rheumatology<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s41927-019-0079-2" target="_blank">http://dx.doi.org/10.1186/s41927-019-0079-2</a></p>2021-08-21T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s41927-019-0079-2https://figshare.com/articles/journal_contribution/Immunoglobulin_abnormalities_are_frequent_in_patients_with_lupus_nephritis/21598551CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215985512021-08-21T06:00:00Z |
| spellingShingle | Immunoglobulin abnormalities are frequent in patients with lupus nephritis M. J. Cuadrado (14153439) Biomedical and clinical sciences Clinical sciences Immunology Immunoglobulins SLE Lupus nephritis Hypogammaglobulinemia Rituximab Autoimmune B-cells |
| status_str | publishedVersion |
| title | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| title_full | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| title_fullStr | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| title_full_unstemmed | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| title_short | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| title_sort | Immunoglobulin abnormalities are frequent in patients with lupus nephritis |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Immunoglobulins SLE Lupus nephritis Hypogammaglobulinemia Rituximab Autoimmune B-cells |