Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events
<h3>Objectives</h3><p dir="ltr">Meta-analyses of rare events often generate unstable results, and selective reporting of the results may mislead the health care decision. Developing a synthesis plan for rare events in protocol may help to formulate the reporting. We aim t...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2020
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| _version_ | 1864513538028994560 |
|---|---|
| author | You Zhou (129411) |
| author2 | Bo Zhu (118038) Lifeng Lin (2034385) Joey S.W. Kwong (16932546) Chang Xu (102022) |
| author2_role | author author author author |
| author_facet | You Zhou (129411) Bo Zhu (118038) Lifeng Lin (2034385) Joey S.W. Kwong (16932546) Chang Xu (102022) |
| author_role | author |
| dc.creator.none.fl_str_mv | You Zhou (129411) Bo Zhu (118038) Lifeng Lin (2034385) Joey S.W. Kwong (16932546) Chang Xu (102022) |
| dc.date.none.fl_str_mv | 2020-09-25T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jclinepi.2020.09.023 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Protocols_for_meta-analysis_of_intervention_safety_seldom_specified_methods_to_deal_with_rare_events/24210699 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Mathematical sciences Statistics Protocols Meta-analysis of rare events Data synthesis plan PROSPERO |
| dc.title.none.fl_str_mv | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objectives</h3><p dir="ltr">Meta-analyses of rare events often generate unstable results, and selective reporting of the results may mislead the health care decision. Developing a synthesis plan for rare events in protocol may help to formulate the reporting. We aim to investigate whether existing protocols specified methods to deal with rare events.</p><h3>Study Design and Setting</h3><p dir="ltr">Protocols (not including Cochrane protocols) for systematic reviews of health care interventions focused on the safety registered in PROSPERO were included. The proportion of protocols that specified methods to deal with rare events and the detailed methods were summarized. We compared the difference of proportions (PD) across different settings.</p><h3>Results</h3><p dir="ltr">We identified 1,004 eligible protocols, of which, 119 (11.85%, 95% confidence interval (CI): 9.92%, 14.01%) specified methods to deal with rare events. The three most commonly planned methods were the Mantel–Haenszel, Peto's odds ratio, and continuity correction. Protocols planned a quantitative analysis (PD = 0.07, 95% CI: 0.02, 0.12; <i>P</i> = 0.004) and listed safety as a primary outcome (PD = 0.07, 95% CI: 0.01, 0.12; <i>P</i> = 0.018) were more likely to specify methods to deal with rare events.</p><h3>Conclusion</h3><p dir="ltr">Protocols for systematic reviews of intervention safety seldom specified methods to deal with rare events. Future systematic reviewers should provide a detailed and rigorous synthesis plan for rare events in their protocols.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Clinical Epidemiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jclinepi.2020.09.023" target="_blank">https://dx.doi.org/10.1016/j.jclinepi.2020.09.023</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_18d85024625d98c92c1b1000e2db33c9 |
| identifier_str_mv | 10.1016/j.jclinepi.2020.09.023 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24210699 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare eventsYou Zhou (129411)Bo Zhu (118038)Lifeng Lin (2034385)Joey S.W. Kwong (16932546)Chang Xu (102022)Biomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyMathematical sciencesStatisticsProtocolsMeta-analysis of rare eventsData synthesis planPROSPERO<h3>Objectives</h3><p dir="ltr">Meta-analyses of rare events often generate unstable results, and selective reporting of the results may mislead the health care decision. Developing a synthesis plan for rare events in protocol may help to formulate the reporting. We aim to investigate whether existing protocols specified methods to deal with rare events.</p><h3>Study Design and Setting</h3><p dir="ltr">Protocols (not including Cochrane protocols) for systematic reviews of health care interventions focused on the safety registered in PROSPERO were included. The proportion of protocols that specified methods to deal with rare events and the detailed methods were summarized. We compared the difference of proportions (PD) across different settings.</p><h3>Results</h3><p dir="ltr">We identified 1,004 eligible protocols, of which, 119 (11.85%, 95% confidence interval (CI): 9.92%, 14.01%) specified methods to deal with rare events. The three most commonly planned methods were the Mantel–Haenszel, Peto's odds ratio, and continuity correction. Protocols planned a quantitative analysis (PD = 0.07, 95% CI: 0.02, 0.12; <i>P</i> = 0.004) and listed safety as a primary outcome (PD = 0.07, 95% CI: 0.01, 0.12; <i>P</i> = 0.018) were more likely to specify methods to deal with rare events.</p><h3>Conclusion</h3><p dir="ltr">Protocols for systematic reviews of intervention safety seldom specified methods to deal with rare events. Future systematic reviewers should provide a detailed and rigorous synthesis plan for rare events in their protocols.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Clinical Epidemiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jclinepi.2020.09.023" target="_blank">https://dx.doi.org/10.1016/j.jclinepi.2020.09.023</a></p>2020-09-25T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jclinepi.2020.09.023https://figshare.com/articles/journal_contribution/Protocols_for_meta-analysis_of_intervention_safety_seldom_specified_methods_to_deal_with_rare_events/24210699CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242106992020-09-25T00:00:00Z |
| spellingShingle | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events You Zhou (129411) Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Mathematical sciences Statistics Protocols Meta-analysis of rare events Data synthesis plan PROSPERO |
| status_str | publishedVersion |
| title | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| title_full | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| title_fullStr | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| title_full_unstemmed | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| title_short | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| title_sort | Protocols for meta-analysis of intervention safety seldom specified methods to deal with rare events |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology Mathematical sciences Statistics Protocols Meta-analysis of rare events Data synthesis plan PROSPERO |