The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome
<h3>Background</h3><p dir="ltr">Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chronic inflammation of adipose tissue may link PCOS and adverse CVR. In pro-inflammatory states such as PCOS...
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| منشور في: |
2019
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| _version_ | 1864513521765580800 |
|---|---|
| author | Thozhukat Sathyapalan (704787) |
| author2 | James P. Hobkirk (18140275) Zeeshan Javed (9975180) Sean Carroll (1723798) Anne-Marie Coady (18140278) Philip Pemberton (18140281) Alexander Smith (326930) Katherine Cianflone (155973) Stephen L. Atkin (6684368) |
| author2_role | author author author author author author author author |
| author_facet | Thozhukat Sathyapalan (704787) James P. Hobkirk (18140275) Zeeshan Javed (9975180) Sean Carroll (1723798) Anne-Marie Coady (18140278) Philip Pemberton (18140281) Alexander Smith (326930) Katherine Cianflone (155973) Stephen L. Atkin (6684368) |
| author_role | author |
| dc.creator.none.fl_str_mv | Thozhukat Sathyapalan (704787) James P. Hobkirk (18140275) Zeeshan Javed (9975180) Sean Carroll (1723798) Anne-Marie Coady (18140278) Philip Pemberton (18140281) Alexander Smith (326930) Katherine Cianflone (155973) Stephen L. Atkin (6684368) |
| dc.date.none.fl_str_mv | 2019-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2019.00394 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Effect_of_Atorvastatin_and_Subsequent_Metformin_on_Adipose_Tissue_Acylation-Stimulatory-Protein_Concentration_and_Inflammatory_Biomarkers_in_Overweight_Obese_Women_With_Polycystic_Ovary_Syndrome/25390657 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences atorvastatin acylation-stimulating-protein interleukin-6 monocyte-chemoattractant-protein-1 adipose tissue PCOS |
| dc.title.none.fl_str_mv | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chronic inflammation of adipose tissue may link PCOS and adverse CVR. In pro-inflammatory states such as PCOS, spontaneous activation of the alternative pathway of complement results in increased generation of acylation stimulating protein (ASP) from adipocytes irrespective of body mass index.</p><h3>Methods</h3><p dir="ltr">The objective of this study was to determine the effect of atorvastatin on markers of adipose tissue dysfunction and inflammation; acylation-stimulating-protein (ASP), interleukin-6 (IL-6), and monocyte-chemoattractant-protein-1 (MCP-1) in PCOS. This was a randomized, double-blind, placebo-controlled study where 40 medication-naive women with PCOS and biochemical hyperandrogenaemia were randomized to either atorvastatin 20 mg daily or placebo for 12 weeks. Following the 12 week randomization; both group of women with PCOS were subsequently started on metformin 1,500 mg daily for further 12 weeks to assess whether pre-treatment with atorvastatin potentiates the effects of metformin on markers of adipose tissue function We conducted a post-hoc review to detect plasma ASP and the pro-inflammatory cytokines IL6 and MCP-1 before and after 12 and 24 weeks of treatment.</p><h3>Results</h3><p dir="ltr">There was significant reduction in ASP (156.7 ± 16.2 vs. 124.4 ± 14.8 ng/ml p <0.01), IL-6 (1.48 ± 0.29 vs.0.73 ± 0.34 pg/ml p = 0.01) and MCP-1 (30.4 ± 4.2 vs. 23.0 ± 4.5 pg/ml p = 0.02) after 12 weeks of atorvastatin that was maintained subsequently with 12 weeks treatment with metformin. There was a significant positive correlation between ASP levels with CRP (p < 0.01), testosterone (p < 0.01) and HOMA-IR (p < 0.01); IL-6 levels with CRP (p <0.01) and testosterone (p < 0.01) and MCP-1 with CRP (p < 0.01); testosterone (p < 0.01) and HOMA-IR (p < 0.02).</p><h3>Conclusions</h3><p dir="ltr">This post-hoc analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS. Changes in adipose tissue markers were significantly associative with substantial improvements in HOMA-IR, testosterone and hs-CRP levels.</p><p><br></p><p dir="ltr">ISRCTN Number: ISRCTN24474824</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00394" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00394</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_18ec6bea8f5745dfce61541036d18988 |
| identifier_str_mv | 10.3389/fendo.2019.00394 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25390657 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary SyndromeThozhukat Sathyapalan (704787)James P. Hobkirk (18140275)Zeeshan Javed (9975180)Sean Carroll (1723798)Anne-Marie Coady (18140278)Philip Pemberton (18140281)Alexander Smith (326930)Katherine Cianflone (155973)Stephen L. Atkin (6684368)Biomedical and clinical sciencesClinical sciencesatorvastatinacylation-stimulating-proteininterleukin-6monocyte-chemoattractant-protein-1adipose tissuePCOS<h3>Background</h3><p dir="ltr">Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chronic inflammation of adipose tissue may link PCOS and adverse CVR. In pro-inflammatory states such as PCOS, spontaneous activation of the alternative pathway of complement results in increased generation of acylation stimulating protein (ASP) from adipocytes irrespective of body mass index.</p><h3>Methods</h3><p dir="ltr">The objective of this study was to determine the effect of atorvastatin on markers of adipose tissue dysfunction and inflammation; acylation-stimulating-protein (ASP), interleukin-6 (IL-6), and monocyte-chemoattractant-protein-1 (MCP-1) in PCOS. This was a randomized, double-blind, placebo-controlled study where 40 medication-naive women with PCOS and biochemical hyperandrogenaemia were randomized to either atorvastatin 20 mg daily or placebo for 12 weeks. Following the 12 week randomization; both group of women with PCOS were subsequently started on metformin 1,500 mg daily for further 12 weeks to assess whether pre-treatment with atorvastatin potentiates the effects of metformin on markers of adipose tissue function We conducted a post-hoc review to detect plasma ASP and the pro-inflammatory cytokines IL6 and MCP-1 before and after 12 and 24 weeks of treatment.</p><h3>Results</h3><p dir="ltr">There was significant reduction in ASP (156.7 ± 16.2 vs. 124.4 ± 14.8 ng/ml p <0.01), IL-6 (1.48 ± 0.29 vs.0.73 ± 0.34 pg/ml p = 0.01) and MCP-1 (30.4 ± 4.2 vs. 23.0 ± 4.5 pg/ml p = 0.02) after 12 weeks of atorvastatin that was maintained subsequently with 12 weeks treatment with metformin. There was a significant positive correlation between ASP levels with CRP (p < 0.01), testosterone (p < 0.01) and HOMA-IR (p < 0.01); IL-6 levels with CRP (p <0.01) and testosterone (p < 0.01) and MCP-1 with CRP (p < 0.01); testosterone (p < 0.01) and HOMA-IR (p < 0.02).</p><h3>Conclusions</h3><p dir="ltr">This post-hoc analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS. Changes in adipose tissue markers were significantly associative with substantial improvements in HOMA-IR, testosterone and hs-CRP levels.</p><p><br></p><p dir="ltr">ISRCTN Number: ISRCTN24474824</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00394" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00394</a></p>2019-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2019.00394https://figshare.com/articles/journal_contribution/The_Effect_of_Atorvastatin_and_Subsequent_Metformin_on_Adipose_Tissue_Acylation-Stimulatory-Protein_Concentration_and_Inflammatory_Biomarkers_in_Overweight_Obese_Women_With_Polycystic_Ovary_Syndrome/25390657CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253906572019-06-01T00:00:00Z |
| spellingShingle | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome Thozhukat Sathyapalan (704787) Biomedical and clinical sciences Clinical sciences atorvastatin acylation-stimulating-protein interleukin-6 monocyte-chemoattractant-protein-1 adipose tissue PCOS |
| status_str | publishedVersion |
| title | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| title_full | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| title_fullStr | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| title_full_unstemmed | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| title_short | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| title_sort | The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome |
| topic | Biomedical and clinical sciences Clinical sciences atorvastatin acylation-stimulating-protein interleukin-6 monocyte-chemoattractant-protein-1 adipose tissue PCOS |