Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar
<p>Human Papillomavirus (HPV) infections are known to cause cervical cancer worldwide, however, limited information is currently available on prevalence, types distribution and risk factors for HPV infection in the Arab countries. We conducted a cross-sectional observational study exclusively...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , |
| Published: |
2017
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513511357415424 |
|---|---|
| author | Asha A. Elmi (3613262) |
| author2 | Devendra Bansal (255958) Anushree Acharya (3613253) Sini Skariah (130134) Soha R. Dargham (3613250) Laith J. Abu-Raddad (9262524) Nady Mohamed-Nady (3613256) Paul Amuna (671264) Asma A. J. Al-Thani (3613259) Ali A. Sultan (7409735) |
| author2_role | author author author author author author author author author |
| author_facet | Asha A. Elmi (3613262) Devendra Bansal (255958) Anushree Acharya (3613253) Sini Skariah (130134) Soha R. Dargham (3613250) Laith J. Abu-Raddad (9262524) Nady Mohamed-Nady (3613256) Paul Amuna (671264) Asma A. J. Al-Thani (3613259) Ali A. Sultan (7409735) |
| author_role | author |
| dc.creator.none.fl_str_mv | Asha A. Elmi (3613262) Devendra Bansal (255958) Anushree Acharya (3613253) Sini Skariah (130134) Soha R. Dargham (3613250) Laith J. Abu-Raddad (9262524) Nady Mohamed-Nady (3613256) Paul Amuna (671264) Asma A. J. Al-Thani (3613259) Ali A. Sultan (7409735) |
| dc.date.none.fl_str_mv | 2017-01-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0169197 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Human_Papillomavirus_HPV_Infection_Molecular_Epidemiology_Genotyping_Seroprevalence_and_Associated_Risk_Factors_among_Arab_Women_in_Qatar/26018143 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Medical microbiology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Human papillomavirus infection Human papillomavirus Arabic people Cytology Qatar Cervical cancer Cancer risk factors Cancer vaccines |
| dc.title.none.fl_str_mv | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Human Papillomavirus (HPV) infections are known to cause cervical cancer worldwide, however, limited information is currently available on prevalence, types distribution and risk factors for HPV infection in the Arab countries. We conducted a cross-sectional observational study exclusively of women of Arabic origin residing in Qatar (n = 406) who were selected from the Women’s Hospital at Hamad Medical Corporation (HMC) and Health Centers of the Primary Health Care Corporation in Doha, Qatar over the period March 2013 to August 2014. Socio-demographic, behavioral and clinical data were collected. Four hundred and six cervical smears and 292 blood samples were included in the study. HPV typing was done using HPV type-specific primers-based real-time PCR, and Sanger sequencing. HPV-IgG and IgM were quantified using ELISA assays. The prevalence of HPV infection amongst Qatari and non-Qatari Arab women were 9.8% and 6.1%, respectively and 7.6% and 16.7% in women with normal and abnormal cytology, respectively. HPV 81 was the most commonly found genotype in women with normal cytology (34.5%), whereas HPV 81, 16 and 59 in women with abnormal cytology (25.0% each). All the HPV DNA positive women were seronegative and HPV-IgG prevalence was higher in Qatari women than in non-Qatari Arab women. None of the studied factors had any significant association with HPV-DNA positivity or HPV-IgG seropositivity. The overall identified HPV DNA prevalence and HPV seroprevalence among Arab women in Qatar were on the low side compared to global levels.</p><h2>Other Information</h2> <p> Published in: PLOS ONE<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0169197" target="_blank">https://dx.doi.org/10.1371/journal.pone.0169197</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1934bc0d736e354ac384bbfdec50445f |
| identifier_str_mv | 10.1371/journal.pone.0169197 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26018143 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in QatarAsha A. Elmi (3613262)Devendra Bansal (255958)Anushree Acharya (3613253)Sini Skariah (130134)Soha R. Dargham (3613250)Laith J. Abu-Raddad (9262524)Nady Mohamed-Nady (3613256)Paul Amuna (671264)Asma A. J. Al-Thani (3613259)Ali A. Sultan (7409735)Biomedical and clinical sciencesImmunologyMedical microbiologyOncology and carcinogenesisPharmacology and pharmaceutical sciencesHuman papillomavirus infectionHuman papillomavirusArabic peopleCytologyQatarCervical cancerCancer risk factorsCancer vaccines<p>Human Papillomavirus (HPV) infections are known to cause cervical cancer worldwide, however, limited information is currently available on prevalence, types distribution and risk factors for HPV infection in the Arab countries. We conducted a cross-sectional observational study exclusively of women of Arabic origin residing in Qatar (n = 406) who were selected from the Women’s Hospital at Hamad Medical Corporation (HMC) and Health Centers of the Primary Health Care Corporation in Doha, Qatar over the period March 2013 to August 2014. Socio-demographic, behavioral and clinical data were collected. Four hundred and six cervical smears and 292 blood samples were included in the study. HPV typing was done using HPV type-specific primers-based real-time PCR, and Sanger sequencing. HPV-IgG and IgM were quantified using ELISA assays. The prevalence of HPV infection amongst Qatari and non-Qatari Arab women were 9.8% and 6.1%, respectively and 7.6% and 16.7% in women with normal and abnormal cytology, respectively. HPV 81 was the most commonly found genotype in women with normal cytology (34.5%), whereas HPV 81, 16 and 59 in women with abnormal cytology (25.0% each). All the HPV DNA positive women were seronegative and HPV-IgG prevalence was higher in Qatari women than in non-Qatari Arab women. None of the studied factors had any significant association with HPV-DNA positivity or HPV-IgG seropositivity. The overall identified HPV DNA prevalence and HPV seroprevalence among Arab women in Qatar were on the low side compared to global levels.</p><h2>Other Information</h2> <p> Published in: PLOS ONE<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0169197" target="_blank">https://dx.doi.org/10.1371/journal.pone.0169197</a></p>2017-01-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1371/journal.pone.0169197https://figshare.com/articles/journal_contribution/Human_Papillomavirus_HPV_Infection_Molecular_Epidemiology_Genotyping_Seroprevalence_and_Associated_Risk_Factors_among_Arab_Women_in_Qatar/26018143CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260181432017-01-03T03:00:00Z |
| spellingShingle | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar Asha A. Elmi (3613262) Biomedical and clinical sciences Immunology Medical microbiology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Human papillomavirus infection Human papillomavirus Arabic people Cytology Qatar Cervical cancer Cancer risk factors Cancer vaccines |
| status_str | publishedVersion |
| title | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| title_full | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| title_fullStr | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| title_full_unstemmed | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| title_short | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| title_sort | Human Papillomavirus (HPV) Infection: Molecular Epidemiology, Genotyping, Seroprevalence and Associated Risk Factors among Arab Women in Qatar |
| topic | Biomedical and clinical sciences Immunology Medical microbiology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Human papillomavirus infection Human papillomavirus Arabic people Cytology Qatar Cervical cancer Cancer risk factors Cancer vaccines |