Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
<p dir="ltr">The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-1...
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2021
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| _version_ | 1864513552605249536 |
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| author | Dore C. Ananthegowda (11659444) |
| author2 | Mohamad Y. Khatib (11659459) Husain S. Ali (11659423) Mohamed Al wraidat (17151067) Yahia Imam (9617067) |
| author2_role | author author author author |
| author_facet | Dore C. Ananthegowda (11659444) Mohamad Y. Khatib (11659459) Husain S. Ali (11659423) Mohamed Al wraidat (17151067) Yahia Imam (9617067) |
| author_role | author |
| dc.creator.none.fl_str_mv | Dore C. Ananthegowda (11659444) Mohamad Y. Khatib (11659459) Husain S. Ali (11659423) Mohamed Al wraidat (17151067) Yahia Imam (9617067) |
| dc.date.none.fl_str_mv | 2021-11-23T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.idcr.2021.e01346 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cytomegalovirus_meningoencephalitis_in_a_case_of_severe_COVID-19_Pneumonia_A_case_report/24314305 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Ganciclovir Case report |
| dc.title.none.fl_str_mv | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-19 pneumonia and hypoxic respiratory failure who was ventilated and received steroids but no other immunomodulatory drugs; had altered sensorium and multiple episodes of seizures in the later course of his illness. Brain MRI showed leptomeningeal enhancement and encephalopathy changes, electroencephalography (EEG) was suggestive of diffuse encephalopathy and his cerebrospinal fluid (CSF) analysis revealed high Cytomegalovirus PCR DNA titers (103,614). The patient made a complete recovery after treatment with Ganciclovir. Altered sensorium in cases of COVID-19 can be multifactorial. High index of suspicion for reactivation of dormant infections is warranted. CMV meningoencephalitis is one of the differential diagnoses. We believe this is the first case reported of CMV meningoencephalitis in the setting of severe COVID-19 infection.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2021.e01346" target="_blank">https://dx.doi.org/10.1016/j.idcr.2021.e01346</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1a740ebe15eaaf0cd585bb9d6fd30df9 |
| identifier_str_mv | 10.1016/j.idcr.2021.e01346 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24314305 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case reportDore C. Ananthegowda (11659444)Mohamad Y. Khatib (11659459)Husain S. Ali (11659423)Mohamed Al wraidat (17151067)Yahia Imam (9617067)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesCMVMeningoencephalitisOpportunistic infectionsCOVID 19ImmunosuppressionSteroidsGanciclovirCase report<p dir="ltr">The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-19 pneumonia and hypoxic respiratory failure who was ventilated and received steroids but no other immunomodulatory drugs; had altered sensorium and multiple episodes of seizures in the later course of his illness. Brain MRI showed leptomeningeal enhancement and encephalopathy changes, electroencephalography (EEG) was suggestive of diffuse encephalopathy and his cerebrospinal fluid (CSF) analysis revealed high Cytomegalovirus PCR DNA titers (103,614). The patient made a complete recovery after treatment with Ganciclovir. Altered sensorium in cases of COVID-19 can be multifactorial. High index of suspicion for reactivation of dormant infections is warranted. CMV meningoencephalitis is one of the differential diagnoses. We believe this is the first case reported of CMV meningoencephalitis in the setting of severe COVID-19 infection.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2021.e01346" target="_blank">https://dx.doi.org/10.1016/j.idcr.2021.e01346</a></p>2021-11-23T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.idcr.2021.e01346https://figshare.com/articles/journal_contribution/Cytomegalovirus_meningoencephalitis_in_a_case_of_severe_COVID-19_Pneumonia_A_case_report/24314305CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/243143052021-11-23T00:00:00Z |
| spellingShingle | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report Dore C. Ananthegowda (11659444) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Ganciclovir Case report |
| status_str | publishedVersion |
| title | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| title_full | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| title_fullStr | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| title_full_unstemmed | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| title_short | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| title_sort | Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Ganciclovir Case report |