Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI
<h3>Objective</h3><p dir="ltr">Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist‐hip ratio. This study aimed to...
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2024
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| _version_ | 1864513547317280768 |
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| author | Moustafa Al Hariri (307254) |
| author2 | Haya Al‐Sulaiti (21480182) Najeha Anwardeen (11924495) Khaled Naja (17886740) Mohamed A. Elrayess (21398687) |
| author2_role | author author author author |
| author_facet | Moustafa Al Hariri (307254) Haya Al‐Sulaiti (21480182) Najeha Anwardeen (11924495) Khaled Naja (17886740) Mohamed A. Elrayess (21398687) |
| author_role | author |
| dc.creator.none.fl_str_mv | Moustafa Al Hariri (307254) Haya Al‐Sulaiti (21480182) Najeha Anwardeen (11924495) Khaled Naja (17886740) Mohamed A. Elrayess (21398687) |
| dc.date.none.fl_str_mv | 2024-07-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/oby.24070 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Comparing_the_metabolic_signatures_of_obesity_defined_by_waist_circumference_waist_hip_ratio_or_BMI/29235089 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health Obesity Metabolic signatures BMI (Body Mass Index) Qatari population Obesity-related disorders Molecular pathways |
| dc.title.none.fl_str_mv | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist‐hip ratio. This study aimed to determine the metabolic signatures associated with each measure of obesity in the Qatari population.</p><h3>Methods</h3><p dir="ltr">Metabolomics profiling was conducted to identify, quantify, and characterize metabolites in serum samples from the study participants. Inverse rank normalization, principal component analysis, and orthogonal partial least square‐discriminant analysis were used to analyze the metabolomics data.</p><h3>Results</h3><p dir="ltr">This study revealed significant differences in metabolites associated with obesity based on different measurements. In men, phosphatidylcholine and phosphatidylethanolamine metabolites were significantly enriched in individuals classified as having obesity based on the waist‐hip ratio. In women, significant changes were observed in leucine, isoleucine, and valine metabolism metabolites. Unique metabolites were found in the different categorization groups that could serve as biomarkers for assessing many obesity‐related disorders.</p><h3>Conclusions</h3><p dir="ltr">This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Obesity<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/oby.24070" target="_blank">https://dx.doi.org/10.1002/oby.24070</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1b0c0f04744526161aa465b1480019c8 |
| identifier_str_mv | 10.1002/oby.24070 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29235089 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMIMoustafa Al Hariri (307254)Haya Al‐Sulaiti (21480182)Najeha Anwardeen (11924495)Khaled Naja (17886740)Mohamed A. Elrayess (21398687)Biomedical and clinical sciencesMedical biochemistry and metabolomicsHealth sciencesEpidemiologyPublic healthObesityMetabolic signaturesBMI (Body Mass Index)Qatari populationObesity-related disordersMolecular pathways<h3>Objective</h3><p dir="ltr">Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist‐hip ratio. This study aimed to determine the metabolic signatures associated with each measure of obesity in the Qatari population.</p><h3>Methods</h3><p dir="ltr">Metabolomics profiling was conducted to identify, quantify, and characterize metabolites in serum samples from the study participants. Inverse rank normalization, principal component analysis, and orthogonal partial least square‐discriminant analysis were used to analyze the metabolomics data.</p><h3>Results</h3><p dir="ltr">This study revealed significant differences in metabolites associated with obesity based on different measurements. In men, phosphatidylcholine and phosphatidylethanolamine metabolites were significantly enriched in individuals classified as having obesity based on the waist‐hip ratio. In women, significant changes were observed in leucine, isoleucine, and valine metabolism metabolites. Unique metabolites were found in the different categorization groups that could serve as biomarkers for assessing many obesity‐related disorders.</p><h3>Conclusions</h3><p dir="ltr">This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Obesity<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/oby.24070" target="_blank">https://dx.doi.org/10.1002/oby.24070</a></p>2024-07-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/oby.24070https://figshare.com/articles/journal_contribution/Comparing_the_metabolic_signatures_of_obesity_defined_by_waist_circumference_waist_hip_ratio_or_BMI/29235089CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/292350892024-07-05T03:00:00Z |
| spellingShingle | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI Moustafa Al Hariri (307254) Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health Obesity Metabolic signatures BMI (Body Mass Index) Qatari population Obesity-related disorders Molecular pathways |
| status_str | publishedVersion |
| title | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| title_full | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| title_fullStr | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| title_full_unstemmed | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| title_short | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| title_sort | Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health Obesity Metabolic signatures BMI (Body Mass Index) Qatari population Obesity-related disorders Molecular pathways |