Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor
<h3>Background</h3><p dir="ltr">Parkinson's disease is a neurodegenerative disease manifested as increased tremor, bradykinesia, rigidity, and postural instability. Brain-derived neurotrophic factor (BDNF) is essential for neurocognitive function. However, its cardio...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , |
| Published: |
2022
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513541571084288 |
|---|---|
| author | Mahmoud A. Alomari (14780446) |
| author2 | Hanan Khalil (8344038) Omar F. Khabour (8997014) Karem H. Alzoubi (8744904) |
| author2_role | author author author |
| author_facet | Mahmoud A. Alomari (14780446) Hanan Khalil (8344038) Omar F. Khabour (8997014) Karem H. Alzoubi (8744904) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mahmoud A. Alomari (14780446) Hanan Khalil (8344038) Omar F. Khabour (8997014) Karem H. Alzoubi (8744904) |
| dc.date.none.fl_str_mv | 2022-12-15T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.lfs.2022.121144 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Lipid_profile_in_Parkinson_s_disease_The_potential_role_of_brain-derived_neurotrophic_factor/24501190 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Neurosciences Parkinson's disease Brain-derived neurotrophic factor Cholesterol LDL HDL Triglycerides |
| dc.title.none.fl_str_mv | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Parkinson's disease is a neurodegenerative disease manifested as increased tremor, bradykinesia, rigidity, and postural instability. Brain-derived neurotrophic factor (BDNF) is essential for neurocognitive function. However, its cardiometabolic effect has recently been identified in health and disease, but not in PD. Therefore, the current study examined the relationship of BDNF with glucose and lipid profile.</p><h3>Methods</h3><p dir="ltr">This was a cross sectional comparative study where PD patients (n = 26) and age-matched healthy controls (n = 27) were recruited. Blood samples were drawn to determine BDNF, glucose, and lipid profile including total cholesterol (TC), HDL, LDL, triglyceride (TriG).</p><h3>Result</h3><p dir="ltr">The linear regression showed that BDNF predicted 11.9 % of TC (p = 0.05), 3.0 % of HDL (p = 0.003), 27.3 % of LDL (p = 0.006), 16.6 % of TriG (p = 0.04), 15.8 % of TC/HDL (p = 0.06), 22.1 % of TC/LDL (p = 0.01), and 35.1 % of TriG/HDL (p = 0.001) but not glucose (B = -0.006; CI = -0.19/0.18; F = 0.005; p = 0.9) and LDL/HDL (B = 0.06; CI = -0.17/0.3; F = 0.3; p = 0.6). Subsequent ANCOVA revealed differences (p < 0.05) in TC, HDL, LDL, TC/LDL, and TriG/HDL but not in glucose, TriG, and TC/HDL among the patients with low-BDNF versus high-BDNF.</p><h3>Significance</h3><p dir="ltr">The results demonstrate a relationship of BDNF with lipid profile suggesting the importance of BDNF for lipid metabolism in PD.</p><h2>Other Information</h2><p dir="ltr">Published in: Life Sciences<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.lfs.2022.121144" target="_blank">https://dx.doi.org/10.1016/j.lfs.2022.121144</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1b367d3be1c39faa6ff9894c096aad72 |
| identifier_str_mv | 10.1016/j.lfs.2022.121144 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24501190 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factorMahmoud A. Alomari (14780446)Hanan Khalil (8344038)Omar F. Khabour (8997014)Karem H. Alzoubi (8744904)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesNeurosciencesParkinson's diseaseBrain-derived neurotrophic factorCholesterolLDLHDLTriglycerides<h3>Background</h3><p dir="ltr">Parkinson's disease is a neurodegenerative disease manifested as increased tremor, bradykinesia, rigidity, and postural instability. Brain-derived neurotrophic factor (BDNF) is essential for neurocognitive function. However, its cardiometabolic effect has recently been identified in health and disease, but not in PD. Therefore, the current study examined the relationship of BDNF with glucose and lipid profile.</p><h3>Methods</h3><p dir="ltr">This was a cross sectional comparative study where PD patients (n = 26) and age-matched healthy controls (n = 27) were recruited. Blood samples were drawn to determine BDNF, glucose, and lipid profile including total cholesterol (TC), HDL, LDL, triglyceride (TriG).</p><h3>Result</h3><p dir="ltr">The linear regression showed that BDNF predicted 11.9 % of TC (p = 0.05), 3.0 % of HDL (p = 0.003), 27.3 % of LDL (p = 0.006), 16.6 % of TriG (p = 0.04), 15.8 % of TC/HDL (p = 0.06), 22.1 % of TC/LDL (p = 0.01), and 35.1 % of TriG/HDL (p = 0.001) but not glucose (B = -0.006; CI = -0.19/0.18; F = 0.005; p = 0.9) and LDL/HDL (B = 0.06; CI = -0.17/0.3; F = 0.3; p = 0.6). Subsequent ANCOVA revealed differences (p < 0.05) in TC, HDL, LDL, TC/LDL, and TriG/HDL but not in glucose, TriG, and TC/HDL among the patients with low-BDNF versus high-BDNF.</p><h3>Significance</h3><p dir="ltr">The results demonstrate a relationship of BDNF with lipid profile suggesting the importance of BDNF for lipid metabolism in PD.</p><h2>Other Information</h2><p dir="ltr">Published in: Life Sciences<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.lfs.2022.121144" target="_blank">https://dx.doi.org/10.1016/j.lfs.2022.121144</a></p>2022-12-15T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.lfs.2022.121144https://figshare.com/articles/journal_contribution/Lipid_profile_in_Parkinson_s_disease_The_potential_role_of_brain-derived_neurotrophic_factor/24501190CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245011902022-12-15T15:00:00Z |
| spellingShingle | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor Mahmoud A. Alomari (14780446) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Neurosciences Parkinson's disease Brain-derived neurotrophic factor Cholesterol LDL HDL Triglycerides |
| status_str | publishedVersion |
| title | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| title_full | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| title_fullStr | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| title_full_unstemmed | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| title_short | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| title_sort | Lipid profile in Parkinson's disease: The potential role of brain-derived neurotrophic factor |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Neurosciences Parkinson's disease Brain-derived neurotrophic factor Cholesterol LDL HDL Triglycerides |