Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance
<p>Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influe...
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| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2019
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| _version_ | 1864513554524143616 |
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| author | Fatima Al-Khelaifi (4741026) |
| author2 | Ilhame Diboun (3522413) Francesco Donati (4741020) Francesco Botrè (4741056) David Abraham (36404) Aroon Hingorani (256127) Omar Albagha (8977856) Costas Georgakopoulos (4741032) Karsten Suhre (67967) Noha A. Yousri (1392577) Mohamed A. Elrayess (7956179) |
| author2_role | author author author author author author author author author author |
| author_facet | Fatima Al-Khelaifi (4741026) Ilhame Diboun (3522413) Francesco Donati (4741020) Francesco Botrè (4741056) David Abraham (36404) Aroon Hingorani (256127) Omar Albagha (8977856) Costas Georgakopoulos (4741032) Karsten Suhre (67967) Noha A. Yousri (1392577) Mohamed A. Elrayess (7956179) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fatima Al-Khelaifi (4741026) Ilhame Diboun (3522413) Francesco Donati (4741020) Francesco Botrè (4741056) David Abraham (36404) Aroon Hingorani (256127) Omar Albagha (8977856) Costas Georgakopoulos (4741032) Karsten Suhre (67967) Noha A. Yousri (1392577) Mohamed A. Elrayess (7956179) |
| dc.date.none.fl_str_mv | 2019-12-27T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41598-019-56496-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolic_GWAS_of_elite_athletes_reveals_novel_genetically-influenced_metabolites_associated_with_athletic_performance/21598143 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Genetic Predisposition Elite Athletic Performance Endurance Sports Metabolomics Profiling Elite Athletes |
| dc.title.none.fl_str_mv | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influenced metabolites that discriminate elite athletes from non-elite athletes and to identify those associated with endurance sports. By conducting a genome wide association study with high-resolution metabolomics profiling in 490 elite athletes, common variant metabolic quantitative trait loci (mQTLs) were identified and compared with previously identified mQTLs in non-elite athletes. Among the identified mQTLs, those associated with endurance metabolites were determined. Two novel genetic loci in FOLH1 and VNN1 are reported in association with N-acetyl-aspartyl-glutamate and Linoleoyl ethanolamide, respectively. When focusing on endurance metabolites, one novel mQTL linking androstenediol (3alpha, 17alpha) monosulfate and SULT2A1 was identified. Potential interactions between the novel identified mQTLs and exercise are highlighted. This is the first report of common variant mQTLs linked to elite athletic performance and endurance sports with potential applications in biomarker discovery in elite athletic candidates, non-conventional anti-doping analytical approaches and therapeutic strategies.</p><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41598-019-56496-7" target="_blank">http://dx.doi.org/10.1038/s41598-019-56496-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1bb889951364c2ba9142c9912ef7f135 |
| identifier_str_mv | 10.1038/s41598-019-56496-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598143 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performanceFatima Al-Khelaifi (4741026)Ilhame Diboun (3522413)Francesco Donati (4741020)Francesco Botrè (4741056)David Abraham (36404)Aroon Hingorani (256127)Omar Albagha (8977856)Costas Georgakopoulos (4741032)Karsten Suhre (67967)Noha A. Yousri (1392577)Mohamed A. Elrayess (7956179)Biomedical and clinical sciencesMedical biochemistry and metabolomicsHealth sciencesSports science and exerciseGenetic PredispositionElite Athletic PerformanceEndurance SportsMetabolomics ProfilingElite Athletes<p>Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influenced metabolites that discriminate elite athletes from non-elite athletes and to identify those associated with endurance sports. By conducting a genome wide association study with high-resolution metabolomics profiling in 490 elite athletes, common variant metabolic quantitative trait loci (mQTLs) were identified and compared with previously identified mQTLs in non-elite athletes. Among the identified mQTLs, those associated with endurance metabolites were determined. Two novel genetic loci in FOLH1 and VNN1 are reported in association with N-acetyl-aspartyl-glutamate and Linoleoyl ethanolamide, respectively. When focusing on endurance metabolites, one novel mQTL linking androstenediol (3alpha, 17alpha) monosulfate and SULT2A1 was identified. Potential interactions between the novel identified mQTLs and exercise are highlighted. This is the first report of common variant mQTLs linked to elite athletic performance and endurance sports with potential applications in biomarker discovery in elite athletic candidates, non-conventional anti-doping analytical approaches and therapeutic strategies.</p><h2>Other Information</h2> <p> Published in: Scientific Reports<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41598-019-56496-7" target="_blank">http://dx.doi.org/10.1038/s41598-019-56496-7</a></p>2019-12-27T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41598-019-56496-7https://figshare.com/articles/journal_contribution/Metabolic_GWAS_of_elite_athletes_reveals_novel_genetically-influenced_metabolites_associated_with_athletic_performance/21598143CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215981432019-12-27T03:00:00Z |
| spellingShingle | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance Fatima Al-Khelaifi (4741026) Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Genetic Predisposition Elite Athletic Performance Endurance Sports Metabolomics Profiling Elite Athletes |
| status_str | publishedVersion |
| title | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| title_full | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| title_fullStr | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| title_full_unstemmed | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| title_short | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| title_sort | Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise Genetic Predisposition Elite Athletic Performance Endurance Sports Metabolomics Profiling Elite Athletes |