Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content
<div><p>The preventive effect of high-dose (9%) regular-fish oil (FO) against bone loss during aging has been demonstrated, but the effects of a low-dose (1%–4%) of a highly purified concentrated FO (CFO) has not been elucidated. The aim of this study was to determine the dose-dependent...
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2019
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| _version_ | 1864513525996584960 |
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| author | Haissam Abou-Saleh (497840) |
| author2 | Allal Ouhtit (526) Ganesh V. Halade (7423028) Md Mizanur Rahman (3717739) |
| author2_role | author author author |
| author_facet | Haissam Abou-Saleh (497840) Allal Ouhtit (526) Ganesh V. Halade (7423028) Md Mizanur Rahman (3717739) |
| author_role | author |
| dc.creator.none.fl_str_mv | Haissam Abou-Saleh (497840) Allal Ouhtit (526) Ganesh V. Halade (7423028) Md Mizanur Rahman (3717739) |
| dc.date.none.fl_str_mv | 2019-11-08T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/nu11112701 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Bone_Benefits_of_Fish_Oil_Supplementation_Depend_on_its_EPA_and_DHA_Content/25304260 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics omega-3 fatty acids concentrated fish oil aging bone mineral density inflammation bone resorption cytokines |
| dc.title.none.fl_str_mv | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The preventive effect of high-dose (9%) regular-fish oil (FO) against bone loss during aging has been demonstrated, but the effects of a low-dose (1%–4%) of a highly purified concentrated FO (CFO) has not been elucidated. The aim of this study was to determine the dose-dependent effect of a CFO against bone loss in C57BL/6 female mice during aging. Twelve-month old mice were fed with 1% and 4% CFO and 4% safflower oil (SFO) diets, including a group with a 4% regular-FO diet and a group with a lab chow diet for 12 months. Bone mineral density (BMD) was analyzed by dual-energy x-ray absorptiometry (DXA) before and after the dietary intervention. At the end of dietary intervention, bone resorption markers in serum and inflammatory markers in bone marrow and splenocytes and inflammatory signaling pathways in the bone marrow were analyzed. As compared to the 4% SFO control, 4% CFO maintained higher BMD during aging, while 1% CFO offered only a mild benefit. However, the 1% CFO fed group exhibited slightly better BMD than the 4% regular-FO fed group. BMD loss protection by CFO was accompanied by reduced levels of the bone resorption marker, TRAP, and the osteoclast-stimulating-factor, RANKL, without affecting the decoy-receptor of RANKL, osteoprotegerin (OPG). Further, CFO supplementation was associated with an increase in the production of IL-10, IL-12, and IFN-γ and a decrease in the production of TNF-α and IL-6, and the activation of NF-κB, p38 MAPK, and JNK signaling pathways. In conclusion, the supplementation of 4% CFO is very efficient in maintaining BMD during aging, whereas 1% CFO is only mildly beneficial. CFO supplementation starting at middle age may maintain better bone health during aging.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Nutrients<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/nu11112701" target="_blank">https://dx.doi.org/10.3390/nu11112701</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1d9b79f08b04473d438b6b44f78f9ef1 |
| identifier_str_mv | 10.3390/nu11112701 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25304260 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA ContentHaissam Abou-Saleh (497840)Allal Ouhtit (526)Ganesh V. Halade (7423028)Md Mizanur Rahman (3717739)Agricultural, veterinary and food sciencesFood sciencesBiomedical and clinical sciencesNutrition and dieteticsomega-3 fatty acidsconcentrated fish oilagingbone mineral densityinflammationbone resorptioncytokines<div><p>The preventive effect of high-dose (9%) regular-fish oil (FO) against bone loss during aging has been demonstrated, but the effects of a low-dose (1%–4%) of a highly purified concentrated FO (CFO) has not been elucidated. The aim of this study was to determine the dose-dependent effect of a CFO against bone loss in C57BL/6 female mice during aging. Twelve-month old mice were fed with 1% and 4% CFO and 4% safflower oil (SFO) diets, including a group with a 4% regular-FO diet and a group with a lab chow diet for 12 months. Bone mineral density (BMD) was analyzed by dual-energy x-ray absorptiometry (DXA) before and after the dietary intervention. At the end of dietary intervention, bone resorption markers in serum and inflammatory markers in bone marrow and splenocytes and inflammatory signaling pathways in the bone marrow were analyzed. As compared to the 4% SFO control, 4% CFO maintained higher BMD during aging, while 1% CFO offered only a mild benefit. However, the 1% CFO fed group exhibited slightly better BMD than the 4% regular-FO fed group. BMD loss protection by CFO was accompanied by reduced levels of the bone resorption marker, TRAP, and the osteoclast-stimulating-factor, RANKL, without affecting the decoy-receptor of RANKL, osteoprotegerin (OPG). Further, CFO supplementation was associated with an increase in the production of IL-10, IL-12, and IFN-γ and a decrease in the production of TNF-α and IL-6, and the activation of NF-κB, p38 MAPK, and JNK signaling pathways. In conclusion, the supplementation of 4% CFO is very efficient in maintaining BMD during aging, whereas 1% CFO is only mildly beneficial. CFO supplementation starting at middle age may maintain better bone health during aging.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Nutrients<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/nu11112701" target="_blank">https://dx.doi.org/10.3390/nu11112701</a></p>2019-11-08T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/nu11112701https://figshare.com/articles/journal_contribution/Bone_Benefits_of_Fish_Oil_Supplementation_Depend_on_its_EPA_and_DHA_Content/25304260CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253042602019-11-08T03:00:00Z |
| spellingShingle | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content Haissam Abou-Saleh (497840) Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics omega-3 fatty acids concentrated fish oil aging bone mineral density inflammation bone resorption cytokines |
| status_str | publishedVersion |
| title | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| title_full | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| title_fullStr | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| title_full_unstemmed | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| title_short | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| title_sort | Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content |
| topic | Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics omega-3 fatty acids concentrated fish oil aging bone mineral density inflammation bone resorption cytokines |