The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

<p dir="ltr">Activation of AMPK has been associated with pro‐atrophic signaling in muscle. However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. Here we show that the AMPK...

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Bibliographic Details
Main Author: Derek T Hall (18629356) (author)
Other Authors: Takla Griss (832356) (author), Jennifer F Ma (18629359) (author), Brenda Janice Sanchez (18629362) (author), Jason Sadek (18629365) (author), Anne Marie K Tremblay (18629368) (author), Souad Mubaid (18629371) (author), Amr Omer (18629374) (author), Rebecca J Ford (18629377) (author), Nathalie Bedard (232947) (author), Arnim Pause (265677) (author), Simon S Wing (18629380) (author), Sergio Di Marco (387749) (author), Gregory R Steinberg (14471628) (author), Russell G Jones (18629383) (author), Imed‐Eddine Gallouzi (18629386) (author)
Published: 2018
Subjects:
Biomedical and clinical sciences
Clinical sciences
Psychology
Biological psychology
AMPK
cachexia
inflammation
iNOS
metabolism
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