Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
<p>Over the last decade, the zebrafish (<em>Danio rerio</em>) has emerged as a model organism for cardiovascular research. Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transpare...
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2018
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| _version_ | 1864513563225227264 |
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| author | Zain Z. Zakaria (6695093) |
| author2 | Fatiha M. Benslimane (6695087) Gheyath K. Nasrallah (2182598) Samar Shurbaji (9938696) Nadin N. Younes (10977237) Fatima Mraiche (14151369) Sahar I. Da’as (9631717) Huseyin C. Yalcin (14603378) |
| author2_role | author author author author author author author |
| author_facet | Zain Z. Zakaria (6695093) Fatiha M. Benslimane (6695087) Gheyath K. Nasrallah (2182598) Samar Shurbaji (9938696) Nadin N. Younes (10977237) Fatima Mraiche (14151369) Sahar I. Da’as (9631717) Huseyin C. Yalcin (14603378) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zain Z. Zakaria (6695093) Fatiha M. Benslimane (6695087) Gheyath K. Nasrallah (2182598) Samar Shurbaji (9938696) Nadin N. Younes (10977237) Fatima Mraiche (14151369) Sahar I. Da’as (9631717) Huseyin C. Yalcin (14603378) |
| dc.date.none.fl_str_mv | 2018-09-27T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2018/1642684 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Using_Zebrafish_for_Investigating_the_Molecular_Mechanisms_of_Drug-Induced_Cardiotoxicity/22082888 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences General Immunology and Microbiology General Medicine Genetics Molecular Biology |
| dc.title.none.fl_str_mv | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Over the last decade, the zebrafish (<em>Danio rerio</em>) has emerged as a model organism for cardiovascular research. Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transparent, develop externally, and have high fecundity making them suitable for large-scale genetic screening. More recently, zebrafish embryos have been used for the screening of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to exhibit physiological responses that are similar to mammals after exposure to medicinal drugs including xenobiotics, hormones, cancer drugs, and also environmental pollutants, including pesticides and heavy metals. In this review, we provided a summary for recent studies that have used zebrafish to investigate the molecular mechanisms of drug-induced cardiotoxicity. More specifically, we focused on the techniques that were exploited by us and others for cardiovascular toxicity assessment and described several microscopic imaging and analysis protocols that are being used for the estimation of a variety of cardiac hemodynamic parameters. </p> <h2>Other information</h2> <p>Published in: BioMed Research International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2018/1642684" target="_blank">http://dx.doi.org/10.1155/2018/1642684</a> </p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1e4cce417c2c91778852aad49999ea6b |
| identifier_str_mv | 10.1155/2018/1642684 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22082888 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced CardiotoxicityZain Z. Zakaria (6695093)Fatiha M. Benslimane (6695087)Gheyath K. Nasrallah (2182598)Samar Shurbaji (9938696)Nadin N. Younes (10977237)Fatima Mraiche (14151369)Sahar I. Da’as (9631717)Huseyin C. Yalcin (14603378)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesGeneral Immunology and MicrobiologyGeneral MedicineGeneticsMolecular Biology<p>Over the last decade, the zebrafish (<em>Danio rerio</em>) has emerged as a model organism for cardiovascular research. Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish is comparatively low; the embryos are transparent, develop externally, and have high fecundity making them suitable for large-scale genetic screening. More recently, zebrafish embryos have been used for the screening of a variety of toxic agents, particularly for cardiotoxicity testing. Zebrafish has been shown to exhibit physiological responses that are similar to mammals after exposure to medicinal drugs including xenobiotics, hormones, cancer drugs, and also environmental pollutants, including pesticides and heavy metals. In this review, we provided a summary for recent studies that have used zebrafish to investigate the molecular mechanisms of drug-induced cardiotoxicity. More specifically, we focused on the techniques that were exploited by us and others for cardiovascular toxicity assessment and described several microscopic imaging and analysis protocols that are being used for the estimation of a variety of cardiac hemodynamic parameters. </p> <h2>Other information</h2> <p>Published in: BioMed Research International<br> License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br> See article on publisher's website: <a href="http://dx.doi.org/10.1155/2018/1642684" target="_blank">http://dx.doi.org/10.1155/2018/1642684</a> </p>2018-09-27T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2018/1642684https://figshare.com/articles/journal_contribution/Using_Zebrafish_for_Investigating_the_Molecular_Mechanisms_of_Drug-Induced_Cardiotoxicity/22082888CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/220828882018-09-27T00:00:00Z |
| spellingShingle | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity Zain Z. Zakaria (6695093) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences General Immunology and Microbiology General Medicine Genetics Molecular Biology |
| status_str | publishedVersion |
| title | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| title_full | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| title_fullStr | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| title_full_unstemmed | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| title_short | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| title_sort | Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences General Immunology and Microbiology General Medicine Genetics Molecular Biology |