Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts
<p dir="ltr">To colonize and infect the host, arthroconidial yeasts must avoid being killed by the host’s defenses. The formation of biofilms on implanted devices allows fungi to avoid host responses and to disseminate into the host. To better study the mechanisms of infection by art...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , |
| Published: |
2021
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513522187108352 |
|---|---|
| author | Mei ElGindi (23276131) |
| author2 | Rula Al-Baghdadi (23276134) Alex B. Jackman (20379279) Angelina S. Antonyan (23276137) Diana L. McMahon (23276140) Saad J. Taj-Aldeen (14650087) Jonathan S. Finkel (23276143) |
| author2_role | author author author author author author |
| author_facet | Mei ElGindi (23276131) Rula Al-Baghdadi (23276134) Alex B. Jackman (20379279) Angelina S. Antonyan (23276137) Diana L. McMahon (23276140) Saad J. Taj-Aldeen (14650087) Jonathan S. Finkel (23276143) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mei ElGindi (23276131) Rula Al-Baghdadi (23276134) Alex B. Jackman (20379279) Angelina S. Antonyan (23276137) Diana L. McMahon (23276140) Saad J. Taj-Aldeen (14650087) Jonathan S. Finkel (23276143) |
| dc.date.none.fl_str_mv | 2021-07-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1139/cjm-2020-0215 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Where_the_infection_is_isolated_rather_than_the_specific_species_correlates_with_adherence_strength_whereas_biofilm_density_remains_static_in_clinically_isolated_i_Candida_i_and_arthroconidial_yeasts/31444705 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology Biomedical and clinical sciences Immunology Pharmacology and pharmaceutical sciences Health sciences Epidemiology Public health adherence biofilm Candida Trichosporon Magnusiomyces |
| dc.title.none.fl_str_mv | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">To colonize and infect the host, arthroconidial yeasts must avoid being killed by the host’s defenses. The formation of biofilms on implanted devices allows fungi to avoid host responses and to disseminate into the host. To better study the mechanisms of infection by arthroconidial yeasts, adherence and biofilm formation were assayed using patient samples collected over 10 years. In clinical samples, adherence varies within species, but the relative adherence is constant for those samples isolated from the same infection site. Herein we document, for the first time, in-vitro biofilm formation by <i>Trichosporon dohaense, T. ovoides, T. japonicum, T. coremiiforme, Cutaneotrichosporon mucoides, Cutaneotrichosporon cutaneum, Galactomyces candidus, </i>and<i> Magnusiomyces capitatus</i> on clinically relevant catheter material. Analysis of biofilm biomass assays indicated that biofilm mass changes less than 2-fold, regardless of the species. Our results support the hypothesis that most pathogenic fungi can form biofilms, and that biofilm formation is a source of systemic infections.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Canadian Journal of Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1139/cjm-2020-0215" target="_blank">https://dx.doi.org/10.1139/cjm-2020-0215</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1e593a257390c66c0331e5c4a517eb52 |
| identifier_str_mv | 10.1139/cjm-2020-0215 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31444705 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeastsMei ElGindi (23276131)Rula Al-Baghdadi (23276134)Alex B. Jackman (20379279)Angelina S. Antonyan (23276137)Diana L. McMahon (23276140)Saad J. Taj-Aldeen (14650087)Jonathan S. Finkel (23276143)Biological sciencesMicrobiologyBiomedical and clinical sciencesImmunologyPharmacology and pharmaceutical sciencesHealth sciencesEpidemiologyPublic healthadherencebiofilmCandidaTrichosporonMagnusiomyces<p dir="ltr">To colonize and infect the host, arthroconidial yeasts must avoid being killed by the host’s defenses. The formation of biofilms on implanted devices allows fungi to avoid host responses and to disseminate into the host. To better study the mechanisms of infection by arthroconidial yeasts, adherence and biofilm formation were assayed using patient samples collected over 10 years. In clinical samples, adherence varies within species, but the relative adherence is constant for those samples isolated from the same infection site. Herein we document, for the first time, in-vitro biofilm formation by <i>Trichosporon dohaense, T. ovoides, T. japonicum, T. coremiiforme, Cutaneotrichosporon mucoides, Cutaneotrichosporon cutaneum, Galactomyces candidus, </i>and<i> Magnusiomyces capitatus</i> on clinically relevant catheter material. Analysis of biofilm biomass assays indicated that biofilm mass changes less than 2-fold, regardless of the species. Our results support the hypothesis that most pathogenic fungi can form biofilms, and that biofilm formation is a source of systemic infections.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Canadian Journal of Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1139/cjm-2020-0215" target="_blank">https://dx.doi.org/10.1139/cjm-2020-0215</a></p>2021-07-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1139/cjm-2020-0215https://figshare.com/articles/journal_contribution/Where_the_infection_is_isolated_rather_than_the_specific_species_correlates_with_adherence_strength_whereas_biofilm_density_remains_static_in_clinically_isolated_i_Candida_i_and_arthroconidial_yeasts/31444705CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/314447052021-07-01T00:00:00Z |
| spellingShingle | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts Mei ElGindi (23276131) Biological sciences Microbiology Biomedical and clinical sciences Immunology Pharmacology and pharmaceutical sciences Health sciences Epidemiology Public health adherence biofilm Candida Trichosporon Magnusiomyces |
| status_str | publishedVersion |
| title | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| title_full | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| title_fullStr | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| title_full_unstemmed | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| title_short | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| title_sort | Where the infection is isolated rather than the specific species correlates with adherence strength, whereas biofilm density remains static in clinically isolated <i>Candida</i> and arthroconidial yeasts |
| topic | Biological sciences Microbiology Biomedical and clinical sciences Immunology Pharmacology and pharmaceutical sciences Health sciences Epidemiology Public health adherence biofilm Candida Trichosporon Magnusiomyces |