Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study
<h3>Aim</h3><p dir="ltr">We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar.</p><h3>Methods</h3><...
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2023
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| _version_ | 1864513547351883776 |
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| author | Hissa N Alsuwaidi (21407003) |
| author2 | Ashraf I Ahmed (21407006) Hamad A Alkorbi (21407009) Sara M Ali (21407012) Lina N Altarawneh (21407015) Shooq I Uddin (21407018) Sara R Roueentan (21407021) Asmaa A Alhitmi (21407024) Laiche Djouhri (112613) Tawanda Chivese (801864) |
| author2_role | author author author author author author author author author |
| author_facet | Hissa N Alsuwaidi (21407003) Ashraf I Ahmed (21407006) Hamad A Alkorbi (21407009) Sara M Ali (21407012) Lina N Altarawneh (21407015) Shooq I Uddin (21407018) Sara R Roueentan (21407021) Asmaa A Alhitmi (21407024) Laiche Djouhri (112613) Tawanda Chivese (801864) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hissa N Alsuwaidi (21407003) Ashraf I Ahmed (21407006) Hamad A Alkorbi (21407009) Sara M Ali (21407012) Lina N Altarawneh (21407015) Shooq I Uddin (21407018) Sara R Roueentan (21407021) Asmaa A Alhitmi (21407024) Laiche Djouhri (112613) Tawanda Chivese (801864) |
| dc.date.none.fl_str_mv | 2023-03-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/dmso.s393282 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Association_Between_Metabolic_Syndrome_and_Decline_in_Cognitive_Function_A_Cross-Sectional_Study/29126750 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Neurosciences Health sciences Epidemiology Public health metabolic syndrome cognitive dysfunction Middle East and North Africa |
| dc.title.none.fl_str_mv | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aim</h3><p dir="ltr">We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar.</p><h3>Methods</h3><p dir="ltr">We conducted a cross-sectional study on randomly selected participants aged 40– 80 years from the Qatar Biobank, with data on cognitive tests and MetS components. Participants with a history of dementia, stroke, or mental disorders were excluded. MetS was diagnosed using the NCEP-ATP III criteria and cognitive performance was assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Two cognitive function domains were assessed. These are speed of reaction, measured using the Reaction Time (RT), and short-term visual memory, measured using the Paired Associate Learning (PAL) test. Multivariable logistic regression models were used to determine associations between MetS and poor speed of reaction and poor memory performance.</p><h3>Results</h3><p dir="ltr">The mean age of the participants included was 49.8 years (SD 6.7). Of these, 51.9% were females and 88.0% were of Qatari nationality. Most of the 1000 participants had MetS (n=302) or 1– 2 MetS components (n=523), whereas only 170 had no MetS components. There was a strong association between MetS and poor memory performance (OR 1.76, 95% CI 1.04– 2.96, P=0.034), but a weaker association with poor speed of reaction (OR 1.5, 95% CI 0.89– 2.50, P=0.125).</p><h3>Conclusion</h3><p dir="ltr">In middle-aged and elderly individuals, MetS was strongly associated with diminished short-term visual memory, psychomotor coordination and motor speed.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes, Metabolic Syndrome and Obesity<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dmso.s393282" target="_blank">https://dx.doi.org/10.2147/dmso.s393282</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1ef1cc0407eae68c3c211f369844d6d6 |
| identifier_str_mv | 10.2147/dmso.s393282 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29126750 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional StudyHissa N Alsuwaidi (21407003)Ashraf I Ahmed (21407006)Hamad A Alkorbi (21407009)Sara M Ali (21407012)Lina N Altarawneh (21407015)Shooq I Uddin (21407018)Sara R Roueentan (21407021)Asmaa A Alhitmi (21407024)Laiche Djouhri (112613)Tawanda Chivese (801864)Biomedical and clinical sciencesMedical biochemistry and metabolomicsNeurosciencesHealth sciencesEpidemiologyPublic healthmetabolic syndromecognitive dysfunctionMiddle East and North Africa<h3>Aim</h3><p dir="ltr">We investigated whether metabolic syndrome (MetS) is associated with a decline in cognitive function in a cohort of middle-aged and elderly individuals without known cognitive dysfunction diseases in Qatar.</p><h3>Methods</h3><p dir="ltr">We conducted a cross-sectional study on randomly selected participants aged 40– 80 years from the Qatar Biobank, with data on cognitive tests and MetS components. Participants with a history of dementia, stroke, or mental disorders were excluded. MetS was diagnosed using the NCEP-ATP III criteria and cognitive performance was assessed using the Cambridge Neuropsychological Test Automated Battery (CANTAB). Two cognitive function domains were assessed. These are speed of reaction, measured using the Reaction Time (RT), and short-term visual memory, measured using the Paired Associate Learning (PAL) test. Multivariable logistic regression models were used to determine associations between MetS and poor speed of reaction and poor memory performance.</p><h3>Results</h3><p dir="ltr">The mean age of the participants included was 49.8 years (SD 6.7). Of these, 51.9% were females and 88.0% were of Qatari nationality. Most of the 1000 participants had MetS (n=302) or 1– 2 MetS components (n=523), whereas only 170 had no MetS components. There was a strong association between MetS and poor memory performance (OR 1.76, 95% CI 1.04– 2.96, P=0.034), but a weaker association with poor speed of reaction (OR 1.5, 95% CI 0.89– 2.50, P=0.125).</p><h3>Conclusion</h3><p dir="ltr">In middle-aged and elderly individuals, MetS was strongly associated with diminished short-term visual memory, psychomotor coordination and motor speed.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes, Metabolic Syndrome and Obesity<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/dmso.s393282" target="_blank">https://dx.doi.org/10.2147/dmso.s393282</a></p>2023-03-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/dmso.s393282https://figshare.com/articles/journal_contribution/Association_Between_Metabolic_Syndrome_and_Decline_in_Cognitive_Function_A_Cross-Sectional_Study/29126750CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291267502023-03-04T03:00:00Z |
| spellingShingle | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study Hissa N Alsuwaidi (21407003) Biomedical and clinical sciences Medical biochemistry and metabolomics Neurosciences Health sciences Epidemiology Public health metabolic syndrome cognitive dysfunction Middle East and North Africa |
| status_str | publishedVersion |
| title | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| title_full | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| title_fullStr | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| title_full_unstemmed | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| title_short | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| title_sort | Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Neurosciences Health sciences Epidemiology Public health metabolic syndrome cognitive dysfunction Middle East and North Africa |