Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
<p dir="ltr">As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These studies have enabled the development of various...
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2019
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إضافة وسم
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| _version_ | 1864513552177430528 |
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| author | Valentina Karin-Kujundzic (20581289) |
| author2 | Ida Marija Sola (20581292) Nina Predavec (20581295) Anamarija Potkonjak (20581298) Ema Somen (20581301) Pavao Mioc (15361136) Alan Serman (20581304) Semir Vranic (3353012) Ljiljana Serman (20581307) |
| author2_role | author author author author author author author author |
| author_facet | Valentina Karin-Kujundzic (20581289) Ida Marija Sola (20581292) Nina Predavec (20581295) Anamarija Potkonjak (20581298) Ema Somen (20581301) Pavao Mioc (15361136) Alan Serman (20581304) Semir Vranic (3353012) Ljiljana Serman (20581307) |
| author_role | author |
| dc.creator.none.fl_str_mv | Valentina Karin-Kujundzic (20581289) Ida Marija Sola (20581292) Nina Predavec (20581295) Anamarija Potkonjak (20581298) Ema Somen (20581301) Pavao Mioc (15361136) Alan Serman (20581304) Semir Vranic (3353012) Ljiljana Serman (20581307) |
| dc.date.none.fl_str_mv | 2019-11-18T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cells8111459 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Novel_Epigenetic_Biomarkers_in_Pregnancy-Related_Disorders_and_Cancers/28235549 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine cell-free DNA cell-free fetal DNA cell-free tumor DNA extracellular vesicles exosomes microRNA |
| dc.title.none.fl_str_mv | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These studies have enabled the development of various new diagnostic biomarkers, such as free circulating nucleic acids, and detection of their epigenetic changes. Recently, extracellular vesicles including exosomes, microvesicles, oncosomes, and apoptotic bodies have been recognized as powerful diagnostic tools. Extracellular vesicles carry specific proteins, lipids, DNAs, mRNAs, and miRNAs of the cells that produced them, thus reflecting the function of these cells. It is believed that exosomes, in particular, may be the optimal biomarkers of pathological pregnancies and cancers, especially those that are frequently diagnosed at an advanced stage, such as ovarian cancer. In the present review, we survey and critically appraise novel epigenetic biomarkers related to free circulating nucleic acids and extracellular vesicles, focusing especially on their status in trophoblasts (pregnancy) and neoplastic cells (cancers).</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8111459" target="_blank">https://dx.doi.org/10.3390/cells8111459</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_1fc045a69703a902ffbeaa9ab53f77b5 |
| identifier_str_mv | 10.3390/cells8111459 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/28235549 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and CancersValentina Karin-Kujundzic (20581289)Ida Marija Sola (20581292)Nina Predavec (20581295)Anamarija Potkonjak (20581298)Ema Somen (20581301)Pavao Mioc (15361136)Alan Serman (20581304)Semir Vranic (3353012)Ljiljana Serman (20581307)Biomedical and clinical sciencesOncology and carcinogenesisReproductive medicinecell-free DNAcell-free fetal DNAcell-free tumor DNAextracellular vesiclesexosomesmicroRNA<p dir="ltr">As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These studies have enabled the development of various new diagnostic biomarkers, such as free circulating nucleic acids, and detection of their epigenetic changes. Recently, extracellular vesicles including exosomes, microvesicles, oncosomes, and apoptotic bodies have been recognized as powerful diagnostic tools. Extracellular vesicles carry specific proteins, lipids, DNAs, mRNAs, and miRNAs of the cells that produced them, thus reflecting the function of these cells. It is believed that exosomes, in particular, may be the optimal biomarkers of pathological pregnancies and cancers, especially those that are frequently diagnosed at an advanced stage, such as ovarian cancer. In the present review, we survey and critically appraise novel epigenetic biomarkers related to free circulating nucleic acids and extracellular vesicles, focusing especially on their status in trophoblasts (pregnancy) and neoplastic cells (cancers).</p><h2>Other Information</h2><p dir="ltr">Published in: Cells<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8111459" target="_blank">https://dx.doi.org/10.3390/cells8111459</a></p>2019-11-18T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cells8111459https://figshare.com/articles/journal_contribution/Novel_Epigenetic_Biomarkers_in_Pregnancy-Related_Disorders_and_Cancers/28235549CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/282355492019-11-18T09:00:00Z |
| spellingShingle | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers Valentina Karin-Kujundzic (20581289) Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine cell-free DNA cell-free fetal DNA cell-free tumor DNA extracellular vesicles exosomes microRNA |
| status_str | publishedVersion |
| title | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| title_full | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| title_fullStr | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| title_full_unstemmed | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| title_short | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| title_sort | Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Reproductive medicine cell-free DNA cell-free fetal DNA cell-free tumor DNA extracellular vesicles exosomes microRNA |