Neutrophil‐to‐lymphocyte ratio as a predictor of clinical outcomes in critically ill COVID‐19 patients: A retrospective observational study
<p></p><div> <h3> Background</h3> <p>Timely identification of patients at risk of worse clinical outcomes is vital in managing coronavirus disease 2019 (COVID-19). The neutrophil-to-lymphocyte ratio (NLR) calculated from complete blood count can predict the degree...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| الملخص: | <p></p><div> <h3> Background</h3> <p>Timely identification of patients at risk of worse clinical outcomes is vital in managing coronavirus disease 2019 (COVID-19). The neutrophil-to-lymphocyte ratio (NLR) calculated from complete blood count can predict the degree of systemic inflammation and guide therapy accordingly. Hence, we did a study to investigate the role of NLR value on intensive care unit (ICU) admission in predicting clinical outcomes of critically ill COVID-19 patients.</p> <h3> Methods</h3> <p>We conducted a retrospective analysis of electronic health records of COVID-19 patients admitted to ICUs at Hazm Mebaireek General Hospital, Qatar, from March 7, 2020 to July 18, 2020. Patients with an NLR equal to or higher than the cut-off value derived from the receiver operating characteristic curve were compared to those with an NLR value below the cut-off. The primary outcome studied was all-cause ICU mortality. The secondary outcomes evaluated were the requirement of mechanical ventilation and ICU length of stay (LOS).</p> <h3> Results</h3> <p>Five hundred and nineteen patients were admitted to ICUs with severe COVID-19 infection during the study period. Overall, ICU mortality in the study population was 14.6% (76/519). NLR on ICU admission of ≥6.55 was obtained using Youden's index to predict ICU mortality, with a sensitivity of 81% and specificity of 41%. Mortality was significantly higher in patients with age ≥60 years (<i>p</i> < 0.001), chronic kidney disease (<i>p</i> = 0.03), malignancy (<i>p</i> < 0.002), and NLR ≥ 6.55 (<i>p</i> < 0.003). There was also a significant association between the requirement of mechanical ventilation (34.7% vs. 51.8%, <i>p</i> < 0.001) and increased ICU LOS (8 vs. 10 days, <i>p</i> < 0.01) in patients with ICU admission NLR ≥ 6.55.</p> <h3> Conclusion</h3> <p>Higher NLR values on ICU admission are associated with worse clinical outcomes in critically ill COVID-19 patients.</p> </div><p></p><h2>Other Information</h2> <p> Published in: Health Science Reports<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/hsr2.844" target="_blank">http://dx.doi.org/10.1002/hsr2.844</a></p> |
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