Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy

Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy

<h3>Background</h3><p dir="ltr">Cardiac troponin I (<i>TNNI3</i>) gene mutations account for 3% of hypertrophic cardiomyopathy and carriers have a heterogeneous phenotype, with increased risk of sudden cardiac death (SCD). Only one mutation (p.Arg21Cys) has be...

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Bibliographic Details
Main Author: Akl C. Fahed (11514346) (author)
Other Authors: Georges Nemer (295984) (author), Fadi F. Bitar (19239475) (author), Samir Arnaout (6339863) (author), Antoine B. Abchee (19686070) (author), Manal Batrawi (19686073) (author), Athar Khalil (5906330) (author), Ossama K. Abou Hassan (18618628) (author), Steven R. DePalma (9667007) (author), Barbara McDonough (6821369) (author), Mariam T. Arabi (19686076) (author), James S. Ware (7759880) (author), Jonathan G. Seidman (6834896) (author), Christine E. Seidman (6834899) (author)
Published: 2020
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Cardiovascular medicine and haematology
cardiomyopathy
hypertrophic
death
sudden
cardiac
disease
mutation
risk
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