Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study
<h3>Introduction</h3><p dir="ltr">Epidemiological studies have consistently revealed that Vitamin D deficiency is most prevalent in Middle Eastern countries. However, research on the impact of genetic loci and polygenic models related to Vitamin D has primarily focused on...
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| مؤلفون آخرون: | , , , , |
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2023
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| _version_ | 1864513508050206720 |
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| author | Nagham Nafiz Hendi (17064261) |
| author2 | Yasser Al-Sarraj (11721425) Umm-Kulthum Ismail Umlai (19420594) Karsten Suhre (67967) Georges Nemer (295984) Omar Albagha (8977856) |
| author2_role | author author author author author |
| author_facet | Nagham Nafiz Hendi (17064261) Yasser Al-Sarraj (11721425) Umm-Kulthum Ismail Umlai (19420594) Karsten Suhre (67967) Georges Nemer (295984) Omar Albagha (8977856) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nagham Nafiz Hendi (17064261) Yasser Al-Sarraj (11721425) Umm-Kulthum Ismail Umlai (19420594) Karsten Suhre (67967) Georges Nemer (295984) Omar Albagha (8977856) |
| dc.date.none.fl_str_mv | 2023-09-29T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2023.1242257 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Genetic_determinants_of_Vitamin_D_deficiency_in_the_Middle_Eastern_Qatari_population_a_genome-wide_association_study/26661628 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Public health Vitamin D deficiency genome-wide association study genetic predispositions polygenic risk score Middle Eastern |
| dc.title.none.fl_str_mv | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Epidemiological studies have consistently revealed that Vitamin D deficiency is most prevalent in Middle Eastern countries. However, research on the impact of genetic loci and polygenic models related to Vitamin D has primarily focused on European populations.</p><h3>Methods</h3><p dir="ltr">We conducted the first genome-wide association study to identify genetic determinants of Vitamin D levels in Middle Easterners using a whole genome sequencing approach in 6,047 subjects from the Qatar Biobank (QBB) project. We performed a GWAS meta-analysis, combining the QBB cohort with recent European GWAS data from the UK Biobank (involving 345,923 individuals). Additionally, we evaluated the performance of European-derived polygenic risk scores using UK Biobank data in the QBB cohort.</p><h3>Results</h3><p dir="ltr">Our study identified an association between a variant in a known locus for the group-specific component gene (<i>GC</i>), specifically rs2298850 (<i>p</i>-value = 1.71 × 10−<sup>08</sup>, Beta = −0.1285), and Vitamin D levels. Furthermore, our GWAS meta-analysis identified two novel variants at a known locus on chromosome 11, rs67609747 and rs1945603, that reached the GWAS significance threshold. Notably, we observed a moderately high heritability of Vitamin D, estimated at 18%, compared to Europeans. Despite the lower predictive performance of Vitamin D levels in Qataris compared to Europeans, the European-derived polygenic risk scores exhibited significant links to Vitamin D deficiency risk within the QBB cohort.</p><h3>Conclusion</h3><p dir="ltr">This novel study reveals the genetic architecture contributing to Vitamin D deficiency in the Qatari population, emphasizing the genetic heterogeneity across different populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2023.1242257" target="_blank">https://dx.doi.org/10.3389/fnut.2023.1242257</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_211c02e1b669ccc2231dfa1ed4cbc0da |
| identifier_str_mv | 10.3389/fnut.2023.1242257 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26661628 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association studyNagham Nafiz Hendi (17064261)Yasser Al-Sarraj (11721425)Umm-Kulthum Ismail Umlai (19420594)Karsten Suhre (67967)Georges Nemer (295984)Omar Albagha (8977856)Biological sciencesBioinformatics and computational biologyGeneticsBiomedical and clinical sciencesMedical biochemistry and metabolomicsHealth sciencesPublic healthVitamin D deficiencygenome-wide association studygenetic predispositionspolygenic risk scoreMiddle Eastern<h3>Introduction</h3><p dir="ltr">Epidemiological studies have consistently revealed that Vitamin D deficiency is most prevalent in Middle Eastern countries. However, research on the impact of genetic loci and polygenic models related to Vitamin D has primarily focused on European populations.</p><h3>Methods</h3><p dir="ltr">We conducted the first genome-wide association study to identify genetic determinants of Vitamin D levels in Middle Easterners using a whole genome sequencing approach in 6,047 subjects from the Qatar Biobank (QBB) project. We performed a GWAS meta-analysis, combining the QBB cohort with recent European GWAS data from the UK Biobank (involving 345,923 individuals). Additionally, we evaluated the performance of European-derived polygenic risk scores using UK Biobank data in the QBB cohort.</p><h3>Results</h3><p dir="ltr">Our study identified an association between a variant in a known locus for the group-specific component gene (<i>GC</i>), specifically rs2298850 (<i>p</i>-value = 1.71 × 10−<sup>08</sup>, Beta = −0.1285), and Vitamin D levels. Furthermore, our GWAS meta-analysis identified two novel variants at a known locus on chromosome 11, rs67609747 and rs1945603, that reached the GWAS significance threshold. Notably, we observed a moderately high heritability of Vitamin D, estimated at 18%, compared to Europeans. Despite the lower predictive performance of Vitamin D levels in Qataris compared to Europeans, the European-derived polygenic risk scores exhibited significant links to Vitamin D deficiency risk within the QBB cohort.</p><h3>Conclusion</h3><p dir="ltr">This novel study reveals the genetic architecture contributing to Vitamin D deficiency in the Qatari population, emphasizing the genetic heterogeneity across different populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Nutrition<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fnut.2023.1242257" target="_blank">https://dx.doi.org/10.3389/fnut.2023.1242257</a></p>2023-09-29T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fnut.2023.1242257https://figshare.com/articles/journal_contribution/Genetic_determinants_of_Vitamin_D_deficiency_in_the_Middle_Eastern_Qatari_population_a_genome-wide_association_study/26661628CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/266616282023-09-29T09:00:00Z |
| spellingShingle | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study Nagham Nafiz Hendi (17064261) Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Public health Vitamin D deficiency genome-wide association study genetic predispositions polygenic risk score Middle Eastern |
| status_str | publishedVersion |
| title | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| title_full | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| title_fullStr | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| title_full_unstemmed | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| title_short | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| title_sort | Genetic determinants of Vitamin D deficiency in the Middle Eastern Qatari population: a genome-wide association study |
| topic | Biological sciences Bioinformatics and computational biology Genetics Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Public health Vitamin D deficiency genome-wide association study genetic predispositions polygenic risk score Middle Eastern |