Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis

Clinical characteristics and outcomes of care in patients hospitalized with diabetic ketoacidosis

<h3>Aims</h3><p dir="ltr">To assess the clinical characteristics and outcomes of patients hospitalized with DKA.</p><h3>Methods</h3><p dir="ltr">We examined the hospital database for patients admitted with DKA to all government hospitals...

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Main Author: Mohsen S. Eledrisi (17542464) (author)
Other Authors: Haifaa Alkabbani (17542467) (author), Malk Aboawon (17542470) (author), Aya Ali (14637496) (author), Imad Alabdulrazzak (17542473) (author), Maab Elhaj (17542476) (author), Ashraf Ahmed (3593984) (author), Hazim Alqahwachi (17542479) (author), Joanne Daghfal (9538551) (author), Salem A. Beshyah (9606810) (author), Rayaz A. Malik (7372649) (author)
Published: 2022
Subjects:
Biomedical and clinical sciences
Clinical sciences
Medical biochemistry and metabolomics
Diabetes mellitus
Diabetic ketoacidosis
Hyperglycemia
Inpatient mortality
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Summary:<h3>Aims</h3><p dir="ltr">To assess the clinical characteristics and outcomes of patients hospitalized with DKA.</p><h3>Methods</h3><p dir="ltr">We examined the hospital database for patients admitted with DKA to all government hospitals in Qatar over 6 years.</p><h3>Results</h3><p dir="ltr">We evaluated a total of 1330 patients [(37.3 % with type 1 diabetes (T1DM) and 62.7 % with type 2 diabetes (T2DM)] with 1613 episodes of DKA. Patients with T2DM were older than those with T1DM [48.0 (38.0–60.0), 26.0 (21.0–31.0) years] while there was no difference in DKA severity and laboratory values on admission or time to resolution of DKA. Admission to the intensive care unit was higher (38.9 % vs. 26.6 %; P < 0.001) with a longer hospital stay [5 (2.0–9.0) vs. 2 (2.0–4.0) days, P < 0.001] and markedly higher mortality (7.4 % vs. 1 %; P < 0.001) in patients with T2DM compared to T1DM. On multivariable logistic regression analysis, significant predictors of mortality were older age (odds ratio, 1.11; 95 % CI, 1.07–1.15; P = 0.0001), and admission to the intensive care unit (odds ratio, 3.61; 95 % CI, 1.69–7.72;P = 0.001).</p><h3>Conclusion</h3><p dir="ltr">In this national cohort of patients hospitalized with DKA, those with T2DM had a 7-fold increase in inpatient mortality associated with older age and admission to the intensive care unit.</p><h2>Other Information</h2><p dir="ltr">Published in: Diabetes Research and Clinical Practice<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.diabres.2022.110041" target="_blank">https://dx.doi.org/10.1016/j.diabres.2022.110041</a></p>

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