Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature
<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a dreadful novel coronavirus with global health concerns among pregnant women. To date, the vertical transmission of SARS-CoV-2 during pregnancy remains controversial. We briefly report recent findings of placental r...
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2022
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| _version_ | 1864513526475784192 |
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| author | Henry C. Ezechukwu (13253406) |
| author2 | Jiahua Shi (501995) Muinah A. Fowora (3993125) Cornelius A. Diya (13253409) Faiz Elfaki (13253412) Oyelola A. Adegboye (4287826) |
| author2_role | author author author author author |
| author_facet | Henry C. Ezechukwu (13253406) Jiahua Shi (501995) Muinah A. Fowora (3993125) Cornelius A. Diya (13253409) Faiz Elfaki (13253412) Oyelola A. Adegboye (4287826) |
| author_role | author |
| dc.creator.none.fl_str_mv | Henry C. Ezechukwu (13253406) Jiahua Shi (501995) Muinah A. Fowora (3993125) Cornelius A. Diya (13253409) Faiz Elfaki (13253412) Oyelola A. Adegboye (4287826) |
| dc.date.none.fl_str_mv | 2022-08-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmed.2022.962937 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Fetoplacental_transmission_and_placental_response_to_SARS-CoV-2_Evidence_from_the_literature/25284988 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology SARS-CoV-2 placenta vertical transmission COVID-19 maternal-child |
| dc.title.none.fl_str_mv | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a dreadful novel coronavirus with global health concerns among pregnant women. To date, the vertical transmission of SARS-CoV-2 during pregnancy remains controversial. We briefly report recent findings of placental response to SARS-CoV-2 infection and updates on vertical transmission. We systematically searched PubMed and Google Scholar databases according to PRISMA guidelines for studies reporting the effects of SARS-CoV-2 infection on the placenta and possibility of vertical transmission. We identified 45 studies reporting 1,280 human placentas that were analyzed by molecular pathology methods and 11,112 placenta-derived cells from a publicly available database that was analyzed using bioinformatics tools. The main finding of this study is that the SARS-CoV-2 canonical entry receptors (ACE2 and TMPRSS2) are abundantly expressed on the placenta during the first trimester, and this expression diminishes across gestational age. Out of 45 eligible studies identified, 24 (53.34%) showed no evidence of vertical transmission, 15 (33.33%) supported the hypothesis of very rare, low possibility of vertical transmission and 6 (13.33%) were indecisive and had no comment on vertical transmission. Furthermore, 433 placentas from 12 studies were also identified for placental pathology investigation. There was evidence of at least one form of maternal vascular malperfusion (MVM), 57/433 (13.1%), fetal vascular malperfusion (FVM), 81/433 (18.7%) and placental inflammation with excessive infiltration of CD3+ CD8+ lymphocytes, CD68+ macrophages and CD20+ lymphocytes in most of the eligible studies. Decidual vasculopathy (3.2%), infarction (3.2%), chronic histiocytic intervillositis (6.0%), thrombi vasculopathy (5.1%) were also observed in most of the MVM and FVM reported cases. The results indicated that SARS-CoV-2 induces placenta inflammation, and placenta susceptibility to SARS-CoV-2 decreases across the pregnancy window. Thus, SARS-CoV-2 infection in early pregnancy may adversely affect the developing fetus.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmed.2022.962937" target="_blank">https://dx.doi.org/10.3389/fmed.2022.962937</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_22334de64f0d77376c45ff414cddc07c |
| identifier_str_mv | 10.3389/fmed.2022.962937 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25284988 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literatureHenry C. Ezechukwu (13253406)Jiahua Shi (501995)Muinah A. Fowora (3993125)Cornelius A. Diya (13253409)Faiz Elfaki (13253412)Oyelola A. Adegboye (4287826)Biomedical and clinical sciencesCardiovascular medicine and haematologySARS-CoV-2placentavertical transmissionCOVID-19maternal-child<div><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a dreadful novel coronavirus with global health concerns among pregnant women. To date, the vertical transmission of SARS-CoV-2 during pregnancy remains controversial. We briefly report recent findings of placental response to SARS-CoV-2 infection and updates on vertical transmission. We systematically searched PubMed and Google Scholar databases according to PRISMA guidelines for studies reporting the effects of SARS-CoV-2 infection on the placenta and possibility of vertical transmission. We identified 45 studies reporting 1,280 human placentas that were analyzed by molecular pathology methods and 11,112 placenta-derived cells from a publicly available database that was analyzed using bioinformatics tools. The main finding of this study is that the SARS-CoV-2 canonical entry receptors (ACE2 and TMPRSS2) are abundantly expressed on the placenta during the first trimester, and this expression diminishes across gestational age. Out of 45 eligible studies identified, 24 (53.34%) showed no evidence of vertical transmission, 15 (33.33%) supported the hypothesis of very rare, low possibility of vertical transmission and 6 (13.33%) were indecisive and had no comment on vertical transmission. Furthermore, 433 placentas from 12 studies were also identified for placental pathology investigation. There was evidence of at least one form of maternal vascular malperfusion (MVM), 57/433 (13.1%), fetal vascular malperfusion (FVM), 81/433 (18.7%) and placental inflammation with excessive infiltration of CD3+ CD8+ lymphocytes, CD68+ macrophages and CD20+ lymphocytes in most of the eligible studies. Decidual vasculopathy (3.2%), infarction (3.2%), chronic histiocytic intervillositis (6.0%), thrombi vasculopathy (5.1%) were also observed in most of the MVM and FVM reported cases. The results indicated that SARS-CoV-2 induces placenta inflammation, and placenta susceptibility to SARS-CoV-2 decreases across the pregnancy window. Thus, SARS-CoV-2 infection in early pregnancy may adversely affect the developing fetus.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Frontiers in Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmed.2022.962937" target="_blank">https://dx.doi.org/10.3389/fmed.2022.962937</a></p>2022-08-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmed.2022.962937https://figshare.com/articles/journal_contribution/Fetoplacental_transmission_and_placental_response_to_SARS-CoV-2_Evidence_from_the_literature/25284988CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252849882022-08-16T03:00:00Z |
| spellingShingle | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature Henry C. Ezechukwu (13253406) Biomedical and clinical sciences Cardiovascular medicine and haematology SARS-CoV-2 placenta vertical transmission COVID-19 maternal-child |
| status_str | publishedVersion |
| title | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| title_full | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| title_fullStr | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| title_full_unstemmed | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| title_short | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| title_sort | Fetoplacental transmission and placental response to SARS-CoV-2: Evidence from the literature |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology SARS-CoV-2 placenta vertical transmission COVID-19 maternal-child |