Candida auris Blood stream infection- a descriptive study from Qatar
<h3>Background</h3><p dir="ltr">Candida auris is an emerging yeast pathogen that can cause invasive infections, particularly candidemia, in healthcare settings. Candida auris is characterized by resistance to multiple classes of antifungal drugs and high mortality.</p&...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2023
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| _version_ | 1864513526899408896 |
|---|---|
| author | Junais Koleri (17280586) |
| author2 | Hawabibee Mahir Petkar (17945102) Hussam Abdel Rahman S. Al Soub (18001579) Muna A. Rahman S. AlMaslamani (18001582) |
| author2_role | author author author |
| author_facet | Junais Koleri (17280586) Hawabibee Mahir Petkar (17945102) Hussam Abdel Rahman S. Al Soub (18001579) Muna A. Rahman S. AlMaslamani (18001582) |
| author_role | author |
| dc.creator.none.fl_str_mv | Junais Koleri (17280586) Hawabibee Mahir Petkar (17945102) Hussam Abdel Rahman S. Al Soub (18001579) Muna A. Rahman S. AlMaslamani (18001582) |
| dc.date.none.fl_str_mv | 2023-08-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12879-023-08477-5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Candida_auris_Blood_stream_infection-_a_descriptive_study_from_Qatar/25256641 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Candida auris Candidemia COVID-19 Fungemia Blood stream infection |
| dc.title.none.fl_str_mv | Candida auris Blood stream infection- a descriptive study from Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Candida auris is an emerging yeast pathogen that can cause invasive infections, particularly candidemia, in healthcare settings. Candida auris is characterized by resistance to multiple classes of antifungal drugs and high mortality.</p><h3>Objective</h3><p dir="ltr">To describe the risk factors, clinical characteristics, antifungal susceptibility pattern and outcomes of Candida auris blood stream infection.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective review of electronic medical records of C. auris fungemia cases in the facilities under Hamad Medical corporation, Qatar from 1/11/2018 to 31/7/2021. Demographic data, risk factors, antibiogram and 30-day outcome are described.</p><h3>Results</h3><p dir="ltr">We identified 36 patients with C. auris fungemia. Most of the patients were in intensive care unit following severe COVID-19 pneumonia and had received steroids and broad-spectrum antibiotics. Most cases were central line related. Over 90% of isolates were non-susceptible to fluconazole, while amphotericin B resistance reached 85%. Factors associated with high mortality included initial SOFA score of 9 or above and absence of source control.</p><h3>Conclusion</h3><p dir="ltr">Our study reveals a concerning 41.6% mortality rate within 30 days of C. auris candidemia. Furthermore, the prevalence of amphotericin B resistance in Qatar exceeds what has been reported in the literature necessitating further exploration. Echinocandins retains nearly 100% susceptibility and should be prioritized as the treatment of choice. These findings emphasize the need for vigilant monitoring and appropriate management strategies to combat C. auris infections and improve patient outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Infectious Diseases<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12879-023-08477-5" target="_blank">https://dx.doi.org/10.1186/s12879-023-08477-5</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2235ffb48c973d32f099fd83654d0eaa |
| identifier_str_mv | 10.1186/s12879-023-08477-5 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25256641 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Candida auris Blood stream infection- a descriptive study from QatarJunais Koleri (17280586)Hawabibee Mahir Petkar (17945102)Hussam Abdel Rahman S. Al Soub (18001579)Muna A. Rahman S. AlMaslamani (18001582)Biomedical and clinical sciencesClinical sciencesCandida aurisCandidemiaCOVID-19FungemiaBlood stream infection<h3>Background</h3><p dir="ltr">Candida auris is an emerging yeast pathogen that can cause invasive infections, particularly candidemia, in healthcare settings. Candida auris is characterized by resistance to multiple classes of antifungal drugs and high mortality.</p><h3>Objective</h3><p dir="ltr">To describe the risk factors, clinical characteristics, antifungal susceptibility pattern and outcomes of Candida auris blood stream infection.</p><h3>Methods</h3><p dir="ltr">We conducted a retrospective review of electronic medical records of C. auris fungemia cases in the facilities under Hamad Medical corporation, Qatar from 1/11/2018 to 31/7/2021. Demographic data, risk factors, antibiogram and 30-day outcome are described.</p><h3>Results</h3><p dir="ltr">We identified 36 patients with C. auris fungemia. Most of the patients were in intensive care unit following severe COVID-19 pneumonia and had received steroids and broad-spectrum antibiotics. Most cases were central line related. Over 90% of isolates were non-susceptible to fluconazole, while amphotericin B resistance reached 85%. Factors associated with high mortality included initial SOFA score of 9 or above and absence of source control.</p><h3>Conclusion</h3><p dir="ltr">Our study reveals a concerning 41.6% mortality rate within 30 days of C. auris candidemia. Furthermore, the prevalence of amphotericin B resistance in Qatar exceeds what has been reported in the literature necessitating further exploration. Echinocandins retains nearly 100% susceptibility and should be prioritized as the treatment of choice. These findings emphasize the need for vigilant monitoring and appropriate management strategies to combat C. auris infections and improve patient outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: BMC Infectious Diseases<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12879-023-08477-5" target="_blank">https://dx.doi.org/10.1186/s12879-023-08477-5</a></p>2023-08-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12879-023-08477-5https://figshare.com/articles/journal_contribution/Candida_auris_Blood_stream_infection-_a_descriptive_study_from_Qatar/25256641CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252566412023-08-06T03:00:00Z |
| spellingShingle | Candida auris Blood stream infection- a descriptive study from Qatar Junais Koleri (17280586) Biomedical and clinical sciences Clinical sciences Candida auris Candidemia COVID-19 Fungemia Blood stream infection |
| status_str | publishedVersion |
| title | Candida auris Blood stream infection- a descriptive study from Qatar |
| title_full | Candida auris Blood stream infection- a descriptive study from Qatar |
| title_fullStr | Candida auris Blood stream infection- a descriptive study from Qatar |
| title_full_unstemmed | Candida auris Blood stream infection- a descriptive study from Qatar |
| title_short | Candida auris Blood stream infection- a descriptive study from Qatar |
| title_sort | Candida auris Blood stream infection- a descriptive study from Qatar |
| topic | Biomedical and clinical sciences Clinical sciences Candida auris Candidemia COVID-19 Fungemia Blood stream infection |