Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls
<p dir="ltr">Mitochondrial diseases arise due to defects in mitochondrial DNA (mtDNA) or nuclear mitochondrial genes (nDNA), leading to impaired mitochondrial oxidative phosphorylation and dysfunction of organs with particularly high energy requirements. Primary mitochondrial disease...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , |
| منشور في: |
2019
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513514018701312 |
|---|---|
| author | Daniel Erskine (3471959) |
| author2 | Amy K. Reeve (18595183) Tuomo Polvikoski (3582296) Andrew M. Schaefer (18595186) Robert W. Taylor (9392601) Nichola Z. Lax (18595189) Omar El-Agnaf (2134222) Johannes Attems (547213) Gráinne S. Gorman (13835362) Doug M. Turnbull (9392598) Yi Shau Ng (18595192) |
| author2_role | author author author author author author author author author author |
| author_facet | Daniel Erskine (3471959) Amy K. Reeve (18595183) Tuomo Polvikoski (3582296) Andrew M. Schaefer (18595186) Robert W. Taylor (9392601) Nichola Z. Lax (18595189) Omar El-Agnaf (2134222) Johannes Attems (547213) Gráinne S. Gorman (13835362) Doug M. Turnbull (9392598) Yi Shau Ng (18595192) |
| author_role | author |
| dc.creator.none.fl_str_mv | Daniel Erskine (3471959) Amy K. Reeve (18595183) Tuomo Polvikoski (3582296) Andrew M. Schaefer (18595186) Robert W. Taylor (9392601) Nichola Z. Lax (18595189) Omar El-Agnaf (2134222) Johannes Attems (547213) Gráinne S. Gorman (13835362) Doug M. Turnbull (9392598) Yi Shau Ng (18595192) |
| dc.date.none.fl_str_mv | 2019-11-28T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00401-019-02105-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Lewy_body_pathology_is_more_prevalent_in_older_individuals_with_mitochondrial_disease_than_controls/25879483 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Mitochondrial diseases Mitochondrial DNA (mtDNA) Nuclear mitochondrial genes (nDNA) Heritable neurological conditions Alzheimer’s disease (AD) Parkinson’s disease (PD) Lewy body (LB) pathology |
| dc.title.none.fl_str_mv | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Mitochondrial diseases arise due to defects in mitochondrial DNA (mtDNA) or nuclear mitochondrial genes (nDNA), leading to impaired mitochondrial oxidative phosphorylation and dysfunction of organs with particularly high energy requirements. Primary mitochondrial diseases affect 1 in 4300 individuals in the UK, making them amongst the most common heritable neurological conditions [2]. Mitochondrial dysfunction has also been linked to deposition of several sporadic age-associated pathologies, including neurofibrillary tangles of hyperphosphorylated tau protein [3] and Lewy body (LB) pathology consisting of aggregated α-synuclein [4], pathological features of Alzheimer’s disease (AD) and Parkinson’s disease (PD)/dementia with Lewy bodies (DLB), respectively. Therefore, we sought to determine whether older individuals with mitochondrial diseases were at increased risk of developing age-associated neurodegenerative pathologies using post-mortem brain samples collected prospectively at Newcastle Brain Tissue Resource (NBTR).</p><h2>Other Information</h2><p dir="ltr">Published in: Acta Neuropathologica<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00401-019-02105-w" target="_blank">https://dx.doi.org/10.1007/s00401-019-02105-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_225f20e1efe3405185fef0ce8e9d0554 |
| identifier_str_mv | 10.1007/s00401-019-02105-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25879483 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controlsDaniel Erskine (3471959)Amy K. Reeve (18595183)Tuomo Polvikoski (3582296)Andrew M. Schaefer (18595186)Robert W. Taylor (9392601)Nichola Z. Lax (18595189)Omar El-Agnaf (2134222)Johannes Attems (547213)Gráinne S. Gorman (13835362)Doug M. Turnbull (9392598)Yi Shau Ng (18595192)Biomedical and clinical sciencesClinical sciencesNeurosciencesMitochondrial diseasesMitochondrial DNA (mtDNA)Nuclear mitochondrial genes (nDNA)Heritable neurological conditionsAlzheimer’s disease (AD)Parkinson’s disease (PD)Lewy body (LB) pathology<p dir="ltr">Mitochondrial diseases arise due to defects in mitochondrial DNA (mtDNA) or nuclear mitochondrial genes (nDNA), leading to impaired mitochondrial oxidative phosphorylation and dysfunction of organs with particularly high energy requirements. Primary mitochondrial diseases affect 1 in 4300 individuals in the UK, making them amongst the most common heritable neurological conditions [2]. Mitochondrial dysfunction has also been linked to deposition of several sporadic age-associated pathologies, including neurofibrillary tangles of hyperphosphorylated tau protein [3] and Lewy body (LB) pathology consisting of aggregated α-synuclein [4], pathological features of Alzheimer’s disease (AD) and Parkinson’s disease (PD)/dementia with Lewy bodies (DLB), respectively. Therefore, we sought to determine whether older individuals with mitochondrial diseases were at increased risk of developing age-associated neurodegenerative pathologies using post-mortem brain samples collected prospectively at Newcastle Brain Tissue Resource (NBTR).</p><h2>Other Information</h2><p dir="ltr">Published in: Acta Neuropathologica<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00401-019-02105-w" target="_blank">https://dx.doi.org/10.1007/s00401-019-02105-w</a></p>2019-11-28T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00401-019-02105-whttps://figshare.com/articles/journal_contribution/Lewy_body_pathology_is_more_prevalent_in_older_individuals_with_mitochondrial_disease_than_controls/25879483CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258794832019-11-28T09:00:00Z |
| spellingShingle | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls Daniel Erskine (3471959) Biomedical and clinical sciences Clinical sciences Neurosciences Mitochondrial diseases Mitochondrial DNA (mtDNA) Nuclear mitochondrial genes (nDNA) Heritable neurological conditions Alzheimer’s disease (AD) Parkinson’s disease (PD) Lewy body (LB) pathology |
| status_str | publishedVersion |
| title | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| title_full | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| title_fullStr | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| title_full_unstemmed | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| title_short | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| title_sort | Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Mitochondrial diseases Mitochondrial DNA (mtDNA) Nuclear mitochondrial genes (nDNA) Heritable neurological conditions Alzheimer’s disease (AD) Parkinson’s disease (PD) Lewy body (LB) pathology |