Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing
<p dir="ltr">Magnesium (Mg)/Polylactic acid (PLA) composites are promising materials for bone regeneration and tissue engineering applications. PLA is a biodegradable and biocompatible polymer that can be easily processed into various shapes and structures, such as scaffolds, films,...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , |
| منشور في: |
2023
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513509230903296 |
|---|---|
| author | Fawad Ali (2154529) |
| author2 | Ans Al Rashid (14777050) Sumama Nuthana Kalva (17302906) Muammer Koç (8350053) |
| author2_role | author author author |
| author_facet | Fawad Ali (2154529) Ans Al Rashid (14777050) Sumama Nuthana Kalva (17302906) Muammer Koç (8350053) |
| author_role | author |
| dc.creator.none.fl_str_mv | Fawad Ali (2154529) Ans Al Rashid (14777050) Sumama Nuthana Kalva (17302906) Muammer Koç (8350053) |
| dc.date.none.fl_str_mv | 2023-09-30T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ma16196506 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Mg-Doped_PLA_Composite_as_a_Potential_Material_for_Tissue_Engineering_Synthesis_Characterization_and_Additive_Manufacturing/26510242 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Biomedical engineering Additive Manufacturing 3D printing PLA/Mg composite bone tissue engineering |
| dc.title.none.fl_str_mv | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Magnesium (Mg)/Polylactic acid (PLA) composites are promising materials for bone regeneration and tissue engineering applications. PLA is a biodegradable and biocompatible polymer that can be easily processed into various shapes and structures, such as scaffolds, films, and fibers, but has low biodegradability. Mg is a biocompatible metal that has been proven to have good biodegradability and osteoconductivity, which makes it suitable for bone tissue engineering. In this study, we prepared and characterized a Mg/PLA composite as a potential material for direct ink writing (DIW) in 3D printing. The results showed that the addition of Mg has a significant impact on PLA’s thermal and structural properties and has also significantly increased the degradation of PLA. XRD was used to determine the degree of crystallinity in the PLA/Mg composite, which provides insight into its thermal stability and degradation behavior. The crystallization temperature of PLA increased from 168 to 172 °C for a 15 wt% Mg incorporation, and the melting temperature reduced from 333 °C to 285 °C. The surface morphology and composition of these films were analyzed with SEM. The films with 5 wt% of Mg particles displayed the best-ordered honeycomb structure in their film form. Such structures are considered to affect the mechanical, biological and heat/mass transfer properties of the Mg/PLA composites and products. Finally, the composite ink was used as a feed for direct ink writing in 3D printing, and the preliminary 3D printing experiments were successful in resulting in dimensionally and structurally integral scaffold samples. The shape fidelity was not very good, and some research is needed to improve the rheological properties of the ink for DIW 3D printing.</p><h2>Other Information</h2><p dir="ltr">Published in: Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ma16196506" target="_blank">https://dx.doi.org/10.3390/ma16196506</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_22891caf9f954177ed4d4e1fa781a252 |
| identifier_str_mv | 10.3390/ma16196506 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26510242 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive ManufacturingFawad Ali (2154529)Ans Al Rashid (14777050)Sumama Nuthana Kalva (17302906)Muammer Koç (8350053)EngineeringBiomedical engineeringAdditive Manufacturing3D printingPLA/Mg compositebone tissue engineering<p dir="ltr">Magnesium (Mg)/Polylactic acid (PLA) composites are promising materials for bone regeneration and tissue engineering applications. PLA is a biodegradable and biocompatible polymer that can be easily processed into various shapes and structures, such as scaffolds, films, and fibers, but has low biodegradability. Mg is a biocompatible metal that has been proven to have good biodegradability and osteoconductivity, which makes it suitable for bone tissue engineering. In this study, we prepared and characterized a Mg/PLA composite as a potential material for direct ink writing (DIW) in 3D printing. The results showed that the addition of Mg has a significant impact on PLA’s thermal and structural properties and has also significantly increased the degradation of PLA. XRD was used to determine the degree of crystallinity in the PLA/Mg composite, which provides insight into its thermal stability and degradation behavior. The crystallization temperature of PLA increased from 168 to 172 °C for a 15 wt% Mg incorporation, and the melting temperature reduced from 333 °C to 285 °C. The surface morphology and composition of these films were analyzed with SEM. The films with 5 wt% of Mg particles displayed the best-ordered honeycomb structure in their film form. Such structures are considered to affect the mechanical, biological and heat/mass transfer properties of the Mg/PLA composites and products. Finally, the composite ink was used as a feed for direct ink writing in 3D printing, and the preliminary 3D printing experiments were successful in resulting in dimensionally and structurally integral scaffold samples. The shape fidelity was not very good, and some research is needed to improve the rheological properties of the ink for DIW 3D printing.</p><h2>Other Information</h2><p dir="ltr">Published in: Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ma16196506" target="_blank">https://dx.doi.org/10.3390/ma16196506</a></p>2023-09-30T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ma16196506https://figshare.com/articles/journal_contribution/Mg-Doped_PLA_Composite_as_a_Potential_Material_for_Tissue_Engineering_Synthesis_Characterization_and_Additive_Manufacturing/26510242CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/265102422023-09-30T09:00:00Z |
| spellingShingle | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing Fawad Ali (2154529) Engineering Biomedical engineering Additive Manufacturing 3D printing PLA/Mg composite bone tissue engineering |
| status_str | publishedVersion |
| title | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| title_full | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| title_fullStr | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| title_full_unstemmed | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| title_short | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| title_sort | Mg-Doped PLA Composite as a Potential Material for Tissue Engineering—Synthesis, Characterization, and Additive Manufacturing |
| topic | Engineering Biomedical engineering Additive Manufacturing 3D printing PLA/Mg composite bone tissue engineering |