Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury
<p dir="ltr">Bleomycin‐induced lung injury (BILI) is a well‐recognised but potentially life‐threatening complication of ABVD chemotherapy (adriamycin, bleomycin, vinblastine and dacarbazine), often requiring prompt diagnosis and intervention. We present a case of a 43‐year‐old female...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2025
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| _version_ | 1864513531581300736 |
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| author | Aasir M. Suliman (14150217) |
| author2 | Irfan Ul Haq (9853260) Khalid Albsheer (21767534) Mohamed Elgara (9538557) |
| author2_role | author author author |
| author_facet | Aasir M. Suliman (14150217) Irfan Ul Haq (9853260) Khalid Albsheer (21767534) Mohamed Elgara (9538557) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aasir M. Suliman (14150217) Irfan Ul Haq (9853260) Khalid Albsheer (21767534) Mohamed Elgara (9538557) |
| dc.date.none.fl_str_mv | 2025-07-14T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/rcr2.70228 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Rituximab_and_Pirfenidone_in_the_Treatment_of_Steroid_Refractory_Bleomycin_Lung_Injury/30860315 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis bleomycin lung injury pirfenidone pneumonitis rituximab |
| dc.title.none.fl_str_mv | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Bleomycin‐induced lung injury (BILI) is a well‐recognised but potentially life‐threatening complication of ABVD chemotherapy (adriamycin, bleomycin, vinblastine and dacarbazine), often requiring prompt diagnosis and intervention. We present a case of a 43‐year‐old female with Hodgkin's lymphoma who developed progressive respiratory symptoms following her fourth cycle of ABVD. A broad infectious and autoimmune workup was unremarkable, and chest imaging was consistent with interstitial lung disease. Her condition deteriorated despite empirical antibiotics and high‐dose corticosteroids. The addition of rituximab and pirfenidone led to significant clinical and radiological improvement, highlighting the potential role of these agents in managing steroid‐refractory BILI.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Respirology Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/rcr2.70228" target="_blank">https://dx.doi.org/10.1002/rcr2.70228</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_235152a3a7721bb12f83978ffe02cbff |
| identifier_str_mv | 10.1002/rcr2.70228 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30860315 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung InjuryAasir M. Suliman (14150217)Irfan Ul Haq (9853260)Khalid Albsheer (21767534)Mohamed Elgara (9538557)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisbleomycinlung injurypirfenidonepneumonitisrituximab<p dir="ltr">Bleomycin‐induced lung injury (BILI) is a well‐recognised but potentially life‐threatening complication of ABVD chemotherapy (adriamycin, bleomycin, vinblastine and dacarbazine), often requiring prompt diagnosis and intervention. We present a case of a 43‐year‐old female with Hodgkin's lymphoma who developed progressive respiratory symptoms following her fourth cycle of ABVD. A broad infectious and autoimmune workup was unremarkable, and chest imaging was consistent with interstitial lung disease. Her condition deteriorated despite empirical antibiotics and high‐dose corticosteroids. The addition of rituximab and pirfenidone led to significant clinical and radiological improvement, highlighting the potential role of these agents in managing steroid‐refractory BILI.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Respirology Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/rcr2.70228" target="_blank">https://dx.doi.org/10.1002/rcr2.70228</a></p>2025-07-14T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/rcr2.70228https://figshare.com/articles/journal_contribution/Rituximab_and_Pirfenidone_in_the_Treatment_of_Steroid_Refractory_Bleomycin_Lung_Injury/30860315CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/308603152025-07-14T09:00:00Z |
| spellingShingle | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury Aasir M. Suliman (14150217) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis bleomycin lung injury pirfenidone pneumonitis rituximab |
| status_str | publishedVersion |
| title | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| title_full | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| title_fullStr | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| title_full_unstemmed | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| title_short | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| title_sort | Rituximab and Pirfenidone in the Treatment of Steroid‐Refractory Bleomycin Lung Injury |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis bleomycin lung injury pirfenidone pneumonitis rituximab |