A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis
<p dir="ltr">Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles, joints, and ner...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2018
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إضافة وسم
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| _version_ | 1864513526003924992 |
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| author | Duong Thi Bich Thuan (18069361) |
| author2 | Hatem Zayed (835448) Ali H. Eid (5461829) Haissam Abou-Saleh (497840) Gheyath K. Nasrallah (9200525) Arduino A. Mangoni (10931181) Gianfranco Pintus (91638) |
| author2_role | author author author author author author |
| author_facet | Duong Thi Bich Thuan (18069361) Hatem Zayed (835448) Ali H. Eid (5461829) Haissam Abou-Saleh (497840) Gheyath K. Nasrallah (9200525) Arduino A. Mangoni (10931181) Gianfranco Pintus (91638) |
| author_role | author |
| dc.creator.none.fl_str_mv | Duong Thi Bich Thuan (18069361) Hatem Zayed (835448) Ali H. Eid (5461829) Haissam Abou-Saleh (497840) Gheyath K. Nasrallah (9200525) Arduino A. Mangoni (10931181) Gianfranco Pintus (91638) |
| dc.date.none.fl_str_mv | 2018-09-19T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fimmu.2018.01985 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_Potential_Link_Between_Oxidative_Stress_and_Endothelial-to-Mesenchymal_Transition_in_Systemic_Sclerosis/25304251 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Endothelial-to-Mesenchymal Transition oxidative stress reactive oxygen species scleroderma systemic sclerosis |
| dc.title.none.fl_str_mv | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles, joints, and nervous system. These abnormalities are associated with altered secretion of growth factor and profibrotic cytokines, such as transforming growth factor-beta (TGF-β), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth factor (CTGF). Among the cellular responses to this proinflammatory environment, the endothelial cells phenotypic conversion into activated myofibroblasts, a process known as endothelial to mesenchymal transition (EndMT), has been postulated. Reactive oxygen species (ROS) might play a key role in SSs-associated fibrosis and vascular damage by mediating and/or activating TGF-β-induced EndMT, a phenomenon that has been observed in other disease models. In this review, we identified and critically appraised published studies investigating associations ROS and EndMT and the presence of EndMT in SSc, highlighting a potential link between oxidative stress and EndMT in this condition. </p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Immunology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fimmu.2018.01985" target="_blank">https://dx.doi.org/10.3389/fimmu.2018.01985</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_236db6b1a293d4dc39a21a7d5321cf48 |
| identifier_str_mv | 10.3389/fimmu.2018.01985 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25304251 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic SclerosisDuong Thi Bich Thuan (18069361)Hatem Zayed (835448)Ali H. Eid (5461829)Haissam Abou-Saleh (497840)Gheyath K. Nasrallah (9200525)Arduino A. Mangoni (10931181)Gianfranco Pintus (91638)Biomedical and clinical sciencesImmunologyEndothelial-to-Mesenchymal Transitionoxidative stressreactive oxygen speciessclerodermasystemic sclerosis<p dir="ltr">Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, digestive system, kidneys, muscles, joints, and nervous system. These abnormalities are associated with altered secretion of growth factor and profibrotic cytokines, such as transforming growth factor-beta (TGF-β), interleukin-4 (IL-4), platelet-derived growth factor (PDGF), and connective-tissue growth factor (CTGF). Among the cellular responses to this proinflammatory environment, the endothelial cells phenotypic conversion into activated myofibroblasts, a process known as endothelial to mesenchymal transition (EndMT), has been postulated. Reactive oxygen species (ROS) might play a key role in SSs-associated fibrosis and vascular damage by mediating and/or activating TGF-β-induced EndMT, a phenomenon that has been observed in other disease models. In this review, we identified and critically appraised published studies investigating associations ROS and EndMT and the presence of EndMT in SSc, highlighting a potential link between oxidative stress and EndMT in this condition. </p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Immunology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fimmu.2018.01985" target="_blank">https://dx.doi.org/10.3389/fimmu.2018.01985</a></p>2018-09-19T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fimmu.2018.01985https://figshare.com/articles/journal_contribution/A_Potential_Link_Between_Oxidative_Stress_and_Endothelial-to-Mesenchymal_Transition_in_Systemic_Sclerosis/25304251CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253042512018-09-19T03:00:00Z |
| spellingShingle | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis Duong Thi Bich Thuan (18069361) Biomedical and clinical sciences Immunology Endothelial-to-Mesenchymal Transition oxidative stress reactive oxygen species scleroderma systemic sclerosis |
| status_str | publishedVersion |
| title | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| title_full | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| title_fullStr | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| title_full_unstemmed | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| title_short | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| title_sort | A Potential Link Between Oxidative Stress and Endothelial-to-Mesenchymal Transition in Systemic Sclerosis |
| topic | Biomedical and clinical sciences Immunology Endothelial-to-Mesenchymal Transition oxidative stress reactive oxygen species scleroderma systemic sclerosis |