Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted
<div><p>Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent. Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment of choice for several cancer types. It remains effective against testicular, bladder, lung,...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513517973929984 |
|---|---|
| author | Reem Ali (9913494) |
| author2 | Mustapha Aouida (417652) Abdallah Alhaj Sulaiman (18372912) Srinivasan Madhusudan (382058) Dindial Ramotar (208416) |
| author2_role | author author author author |
| author_facet | Reem Ali (9913494) Mustapha Aouida (417652) Abdallah Alhaj Sulaiman (18372912) Srinivasan Madhusudan (382058) Dindial Ramotar (208416) |
| author_role | author |
| dc.creator.none.fl_str_mv | Reem Ali (9913494) Mustapha Aouida (417652) Abdallah Alhaj Sulaiman (18372912) Srinivasan Madhusudan (382058) Dindial Ramotar (208416) |
| dc.date.none.fl_str_mv | 2022-06-29T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms23137241 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Can_Cisplatin_Therapy_Be_Improved_Pathways_That_Can_Be_Targeted/25679868 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis cisplatin cisplatin resistance DNA repair platinum sensitisation |
| dc.title.none.fl_str_mv | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent. Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment of choice for several cancer types. It remains effective against testicular, bladder, lung, head and neck, ovarian, and other cancers. Cisplatin treatment triggers different cellular responses. However, it exerts its cytotoxic effects by generating inter-strand and intra-strand crosslinks in DNA. Tumour cells often develop tolerance mechanisms by effectively repairing cisplatin-induced DNA lesions or tolerate the damage by adopting translesion DNA synthesis. Cisplatin-associated nephrotoxicity is also a huge challenge for effective therapy. Several preclinical and clinical studies attempted to understand the major limitations associated with cisplatin therapy, and so far, there is no definitive solution. As such, a more comprehensive molecular and genetic profiling of patients is needed to identify those individuals that can benefit from platinum therapy. Additionally, the treatment regimen can be improved by combining cisplatin with certain molecular targeted therapies to achieve a balance between tumour toxicity and tolerance mechanisms. In this review, we discuss the importance of various biological processes that contribute to the resistance of cisplatin and its derivatives. We aim to highlight the processes that can be modulated to suppress cisplatin resistance and provide an insight into the role of uptake transporters in enhancing drug efficacy.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms23137241" target="_blank">https://dx.doi.org/10.3390/ijms23137241</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_23741f2efdb85094b8a968fc7320db5b |
| identifier_str_mv | 10.3390/ijms23137241 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25679868 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Can Cisplatin Therapy Be Improved? Pathways That Can Be TargetedReem Ali (9913494)Mustapha Aouida (417652)Abdallah Alhaj Sulaiman (18372912)Srinivasan Madhusudan (382058)Dindial Ramotar (208416)Biomedical and clinical sciencesOncology and carcinogenesiscisplatincisplatin resistanceDNA repairplatinum sensitisation<div><p>Cisplatin (cis-diamminedichloroplatinum (II)) is the oldest known chemotherapeutic agent. Since the identification of its anti-tumour activity, it earned a remarkable place as a treatment of choice for several cancer types. It remains effective against testicular, bladder, lung, head and neck, ovarian, and other cancers. Cisplatin treatment triggers different cellular responses. However, it exerts its cytotoxic effects by generating inter-strand and intra-strand crosslinks in DNA. Tumour cells often develop tolerance mechanisms by effectively repairing cisplatin-induced DNA lesions or tolerate the damage by adopting translesion DNA synthesis. Cisplatin-associated nephrotoxicity is also a huge challenge for effective therapy. Several preclinical and clinical studies attempted to understand the major limitations associated with cisplatin therapy, and so far, there is no definitive solution. As such, a more comprehensive molecular and genetic profiling of patients is needed to identify those individuals that can benefit from platinum therapy. Additionally, the treatment regimen can be improved by combining cisplatin with certain molecular targeted therapies to achieve a balance between tumour toxicity and tolerance mechanisms. In this review, we discuss the importance of various biological processes that contribute to the resistance of cisplatin and its derivatives. We aim to highlight the processes that can be modulated to suppress cisplatin resistance and provide an insight into the role of uptake transporters in enhancing drug efficacy.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms23137241" target="_blank">https://dx.doi.org/10.3390/ijms23137241</a></p>2022-06-29T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms23137241https://figshare.com/articles/journal_contribution/Can_Cisplatin_Therapy_Be_Improved_Pathways_That_Can_Be_Targeted/25679868CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/256798682022-06-29T03:00:00Z |
| spellingShingle | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted Reem Ali (9913494) Biomedical and clinical sciences Oncology and carcinogenesis cisplatin cisplatin resistance DNA repair platinum sensitisation |
| status_str | publishedVersion |
| title | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| title_full | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| title_fullStr | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| title_full_unstemmed | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| title_short | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| title_sort | Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis cisplatin cisplatin resistance DNA repair platinum sensitisation |