Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players
<h3>Introduction</h3><p dir="ltr">Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study wa...
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2021
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| _version_ | 1864513517542965248 |
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| author | Shamma Al-Muraikhy (11843423) |
| author2 | Maha Sellami (4351159) Alexander S Domling (11843426) Najeha Rizwana (11843429) Abdelali Agouni (181926) Fatima Al-Khelaifi (4741026) Francesco Donati (4741020) Francesco Botre (11843432) Ilhame Diboun (3522413) Mohamed A Elrayess (11843435) |
| author2_role | author author author author author author author author author |
| author_facet | Shamma Al-Muraikhy (11843423) Maha Sellami (4351159) Alexander S Domling (11843426) Najeha Rizwana (11843429) Abdelali Agouni (181926) Fatima Al-Khelaifi (4741026) Francesco Donati (4741020) Francesco Botre (11843432) Ilhame Diboun (3522413) Mohamed A Elrayess (11843435) |
| author_role | author |
| dc.creator.none.fl_str_mv | Shamma Al-Muraikhy (11843423) Maha Sellami (4351159) Alexander S Domling (11843426) Najeha Rizwana (11843429) Abdelali Agouni (181926) Fatima Al-Khelaifi (4741026) Francesco Donati (4741020) Francesco Botre (11843432) Ilhame Diboun (3522413) Mohamed A Elrayess (11843435) |
| dc.date.none.fl_str_mv | 2021-12-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmolb.2021.727144 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Metabolic_Signature_of_Leukocyte_Telomere_Length_in_Elite_Male_Soccer_Players/25730430 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise telomere length elite athletes soccer aging metabolomics |
| dc.title.none.fl_str_mv | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.</p><h3>Methods</h3><p dir="ltr">Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by receiver operating characteristic (ROC) analysis were conducted to identify top metabolites predictive of LTL.</p><h3>Results</h3><p dir="ltr">Sixty-seven metabolites and seven metabolic pathways showed significant associations with LTL. Among enriched pathways, lysophospholipids, benzoate metabolites, and glycine/serine/threonine metabolites were elevated with longer LTL. Conversely, monoacylglycerols, sphingolipid metabolites, long chain fatty acids and polyunsaturated fatty acids were enriched with shorter telomeres. ROC analysis revealed eight metabolites that best predict LTL, including glutamine, N-acetylglutamine, xanthine, beta-sitosterol, N2-acetyllysine, stearoyl-arachidonoyl-glycerol (18:0/20:4), N-acetylserine and 3-7-dimethylurate with AUC of 0.75 (0.64–0.87, p < 0.0001).</p><h3>Conclusion</h3><p dir="ltr">This study characterized the metabolic activity in relation to telomere length in elite soccer players. Investigating the functional relevance of these associations could provide a better understanding of exercise physiology and pathophysiology of elite athletes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Biosciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmolb.2021.727144" target="_blank">https://dx.doi.org/10.3389/fmolb.2021.727144</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_23bf1c624720c466a59eea8697d51dbd |
| identifier_str_mv | 10.3389/fmolb.2021.727144 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25730430 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer PlayersShamma Al-Muraikhy (11843423)Maha Sellami (4351159)Alexander S Domling (11843426)Najeha Rizwana (11843429)Abdelali Agouni (181926)Fatima Al-Khelaifi (4741026)Francesco Donati (4741020)Francesco Botre (11843432)Ilhame Diboun (3522413)Mohamed A Elrayess (11843435)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsHealth sciencesSports science and exercisetelomere lengthelite athletessocceragingmetabolomics<h3>Introduction</h3><p dir="ltr">Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.</p><h3>Methods</h3><p dir="ltr">Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by receiver operating characteristic (ROC) analysis were conducted to identify top metabolites predictive of LTL.</p><h3>Results</h3><p dir="ltr">Sixty-seven metabolites and seven metabolic pathways showed significant associations with LTL. Among enriched pathways, lysophospholipids, benzoate metabolites, and glycine/serine/threonine metabolites were elevated with longer LTL. Conversely, monoacylglycerols, sphingolipid metabolites, long chain fatty acids and polyunsaturated fatty acids were enriched with shorter telomeres. ROC analysis revealed eight metabolites that best predict LTL, including glutamine, N-acetylglutamine, xanthine, beta-sitosterol, N2-acetyllysine, stearoyl-arachidonoyl-glycerol (18:0/20:4), N-acetylserine and 3-7-dimethylurate with AUC of 0.75 (0.64–0.87, p < 0.0001).</p><h3>Conclusion</h3><p dir="ltr">This study characterized the metabolic activity in relation to telomere length in elite soccer players. Investigating the functional relevance of these associations could provide a better understanding of exercise physiology and pathophysiology of elite athletes.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Molecular Biosciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmolb.2021.727144" target="_blank">https://dx.doi.org/10.3389/fmolb.2021.727144</a></p>2021-12-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmolb.2021.727144https://figshare.com/articles/journal_contribution/Metabolic_Signature_of_Leukocyte_Telomere_Length_in_Elite_Male_Soccer_Players/25730430CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257304302021-12-16T03:00:00Z |
| spellingShingle | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players Shamma Al-Muraikhy (11843423) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise telomere length elite athletes soccer aging metabolomics |
| status_str | publishedVersion |
| title | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_full | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_fullStr | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_full_unstemmed | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_short | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_sort | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Health sciences Sports science and exercise telomere length elite athletes soccer aging metabolomics |