Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma
<h3>Introduction</h3><p dir="ltr">Extraskeletal Ewing’s sarcoma is a rare malignancy in the adult population, and its primary renal involvement is even rarer. Renal Ewing’s sarcoma is often metastatic at the initial presentation and has a poor prognosis.</p><h3&g...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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| _version_ | 1864513548288262144 |
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| author | Abdulrahman F. Al-Mashdali (17148316) |
| author2 | Mohammad S. Naser (21363197) Khaled Murshed (8309781) Hassan Aakel (21363200) Alaaeldin Shablak (14778097) |
| author2_role | author author author author |
| author_facet | Abdulrahman F. Al-Mashdali (17148316) Mohammad S. Naser (21363197) Khaled Murshed (8309781) Hassan Aakel (21363200) Alaaeldin Shablak (14778097) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdulrahman F. Al-Mashdali (17148316) Mohammad S. Naser (21363197) Khaled Murshed (8309781) Hassan Aakel (21363200) Alaaeldin Shablak (14778097) |
| dc.date.none.fl_str_mv | 2022-11-07T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md9.0000000000000243 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Isolated_right_oculomotor_nerve_palsy_as_the_first_presenting_manifestation_of_metastatic_renal_Ewing_s_sarcoma/29069438 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis case report extraskeletal Ewing’s sarcoma metastasis oculomotor nerve palsy primary Ewing sarcoma of the kidney renal cancer |
| dc.title.none.fl_str_mv | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Extraskeletal Ewing’s sarcoma is a rare malignancy in the adult population, and its primary renal involvement is even rarer. Renal Ewing’s sarcoma is often metastatic at the initial presentation and has a poor prognosis.</p><h3>Patient concern</h3><p dir="ltr">We present the case of a 53-year-old Filipino woman who presented to our emergency department with acute right oculomotor nerve palsy.</p><h3>Diagnosis</h3><p dir="ltr">Imaging revealed metastatic lesions involving the skull and vertebra as well as the presence of a left kidney mass. Renal biopsy result of the kidney confirmed the diagnosis of renal Ewing's sarcoma.</p><h3>Intervention</h3><p dir="ltr">The patient was started on doxorubicin, vincristine, and cyclophosphamide, alternating with ifosfamide and etoposide.</p><h3>Outcomes</h3><p dir="ltr">The patient developed severe adverse effects from chemotherapy and died 4 months after diagnosis.</p><h3>Conclusion</h3><p dir="ltr">To our knowledge, this is the first case of renal Ewing’s sarcoma that initially presented with neurological manifestations secondary to bone metastasis in the absence of any urological manifestations, such as flank pain or hematuria.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine: Case Reports and Study Protocols<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md9.0000000000000243" target="_blank">https://dx.doi.org/10.1097/md9.0000000000000243</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_24a8d0290594d0b4c258fb3f0833aec9 |
| identifier_str_mv | 10.1097/md9.0000000000000243 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29069438 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcomaAbdulrahman F. Al-Mashdali (17148316)Mohammad S. Naser (21363197)Khaled Murshed (8309781)Hassan Aakel (21363200)Alaaeldin Shablak (14778097)Biomedical and clinical sciencesClinical sciencesNeurosciencesOncology and carcinogenesiscase reportextraskeletal Ewing’s sarcomametastasisoculomotor nerve palsyprimary Ewing sarcoma of the kidneyrenal cancer<h3>Introduction</h3><p dir="ltr">Extraskeletal Ewing’s sarcoma is a rare malignancy in the adult population, and its primary renal involvement is even rarer. Renal Ewing’s sarcoma is often metastatic at the initial presentation and has a poor prognosis.</p><h3>Patient concern</h3><p dir="ltr">We present the case of a 53-year-old Filipino woman who presented to our emergency department with acute right oculomotor nerve palsy.</p><h3>Diagnosis</h3><p dir="ltr">Imaging revealed metastatic lesions involving the skull and vertebra as well as the presence of a left kidney mass. Renal biopsy result of the kidney confirmed the diagnosis of renal Ewing's sarcoma.</p><h3>Intervention</h3><p dir="ltr">The patient was started on doxorubicin, vincristine, and cyclophosphamide, alternating with ifosfamide and etoposide.</p><h3>Outcomes</h3><p dir="ltr">The patient developed severe adverse effects from chemotherapy and died 4 months after diagnosis.</p><h3>Conclusion</h3><p dir="ltr">To our knowledge, this is the first case of renal Ewing’s sarcoma that initially presented with neurological manifestations secondary to bone metastasis in the absence of any urological manifestations, such as flank pain or hematuria.</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine: Case Reports and Study Protocols<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md9.0000000000000243" target="_blank">https://dx.doi.org/10.1097/md9.0000000000000243</a></p>2022-11-07T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md9.0000000000000243https://figshare.com/articles/journal_contribution/Isolated_right_oculomotor_nerve_palsy_as_the_first_presenting_manifestation_of_metastatic_renal_Ewing_s_sarcoma/29069438CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/290694382022-11-07T09:00:00Z |
| spellingShingle | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma Abdulrahman F. Al-Mashdali (17148316) Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis case report extraskeletal Ewing’s sarcoma metastasis oculomotor nerve palsy primary Ewing sarcoma of the kidney renal cancer |
| status_str | publishedVersion |
| title | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| title_full | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| title_fullStr | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| title_full_unstemmed | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| title_short | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| title_sort | Isolated right oculomotor nerve palsy as the first presenting manifestation of metastatic renal Ewing’s sarcoma |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Oncology and carcinogenesis case report extraskeletal Ewing’s sarcoma metastasis oculomotor nerve palsy primary Ewing sarcoma of the kidney renal cancer |