Suspected Agomelatine-induced restless legs syndrome: a case report
<h2>Background</h2> <p>Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It c...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513566623662080 |
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| author | Mustafa Abdul Karim (14159016) |
| author2 | Nadeen Al-Baz (14153124) Sami Ouanes (9617363) Majid Alabdulla (12051430) Peter M. Haddad (14153136) |
| author2_role | author author author author |
| author_facet | Mustafa Abdul Karim (14159016) Nadeen Al-Baz (14153124) Sami Ouanes (9617363) Majid Alabdulla (12051430) Peter M. Haddad (14153136) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mustafa Abdul Karim (14159016) Nadeen Al-Baz (14153124) Sami Ouanes (9617363) Majid Alabdulla (12051430) Peter M. Haddad (14153136) |
| dc.date.none.fl_str_mv | 2022-11-22T21:17:45Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12888-021-03175-5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Suspected_Agomelatine-induced_restless_legs_syndrome_a_case_report/21598335 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical sciences Psychiatry and Mental health |
| dc.title.none.fl_str_mv | Suspected Agomelatine-induced restless legs syndrome: a case report |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h2>Background</h2> <p>Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics.</p> <h2>Case presentation</h2> <p>A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Agomelatine 25 mg at night was added to Escitalopram to treat his residual depressive symptoms, namely insomnia and tiredness. Within two days he developed restlessness and unpleasant sensations in his legs which were worse at night. Symptom severity increased over the following days, prompting an urgent consultation a week later. The patient’s presentation met the criteria for RLS. Agomelatine was discontinued leaving the patient on Escitalopram alone. The patient’s symptoms improved within 24 h of stopping Agomelatine, with complete resolution four days later. There was no recurrence of RLS during follow-up. The patient scored 6 on Naranjo’s adverse drug reaction probability scale, indicating a probable adverse drug reaction caused by Agomelatine.</p> <h2>Conclusions</h2> <p>To the best of our knowledge, this is the first case report of suspected Agomelatine-induced RLS. Clinicians need to be aware of RLS to enable prompt diagnosis and management. We suggest adding Agomelatine to the list of agents that can potentially induce RLS.</p><h2>Other Information</h2> <p> Published in: BMC Psychiatry<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12888-021-03175-5" target="_blank">http://dx.doi.org/10.1186/s12888-021-03175-5</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_24a9cf4be1255cbd8ed3a5aea16084b7 |
| identifier_str_mv | 10.1186/s12888-021-03175-5 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598335 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Suspected Agomelatine-induced restless legs syndrome: a case reportMustafa Abdul Karim (14159016)Nadeen Al-Baz (14153124)Sami Ouanes (9617363)Majid Alabdulla (12051430)Peter M. Haddad (14153136)Clinical sciencesPsychiatry and Mental health<h2>Background</h2> <p>Restless Legs Syndrome (RLS) is a sensorimotor disorder characterized by unpleasant and distressing sensations in the lower limbs that are more pronounced in the evening, commence or worsen at rest, and show partial or complete relief following movement. It can occur as a primary disorder, secondary to medical conditions or treatment with medications including but not limited to antidepressants or antipsychotics.</p> <h2>Case presentation</h2> <p>A 32-year old man with major depressive disorder showed partial response to Escitalopram 10 mg daily. Agomelatine 25 mg at night was added to Escitalopram to treat his residual depressive symptoms, namely insomnia and tiredness. Within two days he developed restlessness and unpleasant sensations in his legs which were worse at night. Symptom severity increased over the following days, prompting an urgent consultation a week later. The patient’s presentation met the criteria for RLS. Agomelatine was discontinued leaving the patient on Escitalopram alone. The patient’s symptoms improved within 24 h of stopping Agomelatine, with complete resolution four days later. There was no recurrence of RLS during follow-up. The patient scored 6 on Naranjo’s adverse drug reaction probability scale, indicating a probable adverse drug reaction caused by Agomelatine.</p> <h2>Conclusions</h2> <p>To the best of our knowledge, this is the first case report of suspected Agomelatine-induced RLS. Clinicians need to be aware of RLS to enable prompt diagnosis and management. We suggest adding Agomelatine to the list of agents that can potentially induce RLS.</p><h2>Other Information</h2> <p> Published in: BMC Psychiatry<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1186/s12888-021-03175-5" target="_blank">http://dx.doi.org/10.1186/s12888-021-03175-5</a></p>2022-11-22T21:17:45ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12888-021-03175-5https://figshare.com/articles/journal_contribution/Suspected_Agomelatine-induced_restless_legs_syndrome_a_case_report/21598335CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215983352022-11-22T21:17:45Z |
| spellingShingle | Suspected Agomelatine-induced restless legs syndrome: a case report Mustafa Abdul Karim (14159016) Clinical sciences Psychiatry and Mental health |
| status_str | publishedVersion |
| title | Suspected Agomelatine-induced restless legs syndrome: a case report |
| title_full | Suspected Agomelatine-induced restless legs syndrome: a case report |
| title_fullStr | Suspected Agomelatine-induced restless legs syndrome: a case report |
| title_full_unstemmed | Suspected Agomelatine-induced restless legs syndrome: a case report |
| title_short | Suspected Agomelatine-induced restless legs syndrome: a case report |
| title_sort | Suspected Agomelatine-induced restless legs syndrome: a case report |
| topic | Clinical sciences Psychiatry and Mental health |