A Novel Green Synthesis of Thalidomide and Analogs
<p dir="ltr">Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an effi...
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2017
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| _version_ | 1864513512312668160 |
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| author | Ellis Benjamin (18891907) |
| author2 | Yousef M. Hijji (3058938) |
| author2_role | author |
| author_facet | Ellis Benjamin (18891907) Yousef M. Hijji (3058938) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ellis Benjamin (18891907) Yousef M. Hijji (3058938) |
| dc.date.none.fl_str_mv | 2017-02-20T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2017/6436185 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_Novel_Green_Synthesis_of_Thalidomide_and_Analogs/26114746 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Antiangiogenic Crohn's disease Neurodegenerative disorders Teratogenic effects |
| dc.title.none.fl_str_mv | A Novel Green Synthesis of Thalidomide and Analogs |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Chemistry<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2017/6436185" target="_blank">https://dx.doi.org/10.1155/2017/6436185</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_24d6bd2c932adc94c4fcc5a785158c5a |
| identifier_str_mv | 10.1155/2017/6436185 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114746 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A Novel Green Synthesis of Thalidomide and AnalogsEllis Benjamin (18891907)Yousef M. Hijji (3058938)Biomedical and clinical sciencesPharmacology and pharmaceutical sciencesChemical sciencesMedicinal and biomolecular chemistryAntiangiogenicCrohn's diseaseNeurodegenerative disordersTeratogenic effects<p dir="ltr">Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Chemistry<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2017/6436185" target="_blank">https://dx.doi.org/10.1155/2017/6436185</a></p>2017-02-20T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2017/6436185https://figshare.com/articles/journal_contribution/A_Novel_Green_Synthesis_of_Thalidomide_and_Analogs/26114746CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261147462017-02-20T09:00:00Z |
| spellingShingle | A Novel Green Synthesis of Thalidomide and Analogs Ellis Benjamin (18891907) Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Antiangiogenic Crohn's disease Neurodegenerative disorders Teratogenic effects |
| status_str | publishedVersion |
| title | A Novel Green Synthesis of Thalidomide and Analogs |
| title_full | A Novel Green Synthesis of Thalidomide and Analogs |
| title_fullStr | A Novel Green Synthesis of Thalidomide and Analogs |
| title_full_unstemmed | A Novel Green Synthesis of Thalidomide and Analogs |
| title_short | A Novel Green Synthesis of Thalidomide and Analogs |
| title_sort | A Novel Green Synthesis of Thalidomide and Analogs |
| topic | Biomedical and clinical sciences Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Antiangiogenic Crohn's disease Neurodegenerative disorders Teratogenic effects |