Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection
<p dir="ltr">Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contract...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2024
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| _version_ | 1864513545037676544 |
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| author | Mohamed Elmarasi (14614276) |
| author2 | Ibrahim Elmakaty (14614270) Basel Elsayed (14614273) Abdelrahman Elsayed (6288913) Jana Al Zein (21633695) Ammar Boudaka (21633698) Ali H. Eid (5461829) |
| author2_role | author author author author author author |
| author_facet | Mohamed Elmarasi (14614276) Ibrahim Elmakaty (14614270) Basel Elsayed (14614273) Abdelrahman Elsayed (6288913) Jana Al Zein (21633695) Ammar Boudaka (21633698) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed Elmarasi (14614276) Ibrahim Elmakaty (14614270) Basel Elsayed (14614273) Abdelrahman Elsayed (6288913) Jana Al Zein (21633695) Ammar Boudaka (21633698) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2024-01-30T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/jcp.31200 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Phenotypic_switching_of_vascular_smooth_muscle_cells_in_atherosclerosis_hypertension_and_aortic_dissection/29446208 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology aneurysm cardiovascular disease extracellular matrix migration theranostics |
| dc.title.none.fl_str_mv | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter. Synthetic VSMCs, on the other hand, are typically found in the tunica intima and adventitia, and are involved in vascular repair and remodeling. Switching between contractile and synthetic phenotypes occurs in response to various insults and stimuli, such as injury or inflammation, and this allows VSMCs to adapt to changing environmental cues and regulate vascular tone, growth, and repair. Furthermore, VSMCs can also switch to osteoblast‐like and chondrocyte‐like cell phenotypes, which may contribute to vascular calcification and other pathological processes like the formation of atherosclerotic plaques. This provides discusses the mechanisms that regulate VSMC phenotypic switching and its role in the development of vascular diseases. A better understanding of these processes is essential for the development of effective diagnostic and therapeutic strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31200" target="_blank">https://dx.doi.org/10.1002/jcp.31200</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_259c6d97399e4a082de4257d6bec76db |
| identifier_str_mv | 10.1002/jcp.31200 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29446208 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissectionMohamed Elmarasi (14614276)Ibrahim Elmakaty (14614270)Basel Elsayed (14614273)Abdelrahman Elsayed (6288913)Jana Al Zein (21633695)Ammar Boudaka (21633698)Ali H. Eid (5461829)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesCardiovascular medicine and haematologyaneurysmcardiovascular diseaseextracellular matrixmigrationtheranostics<p dir="ltr">Vascular smooth muscle cells (VSMCs) play a critical role in regulating vasotone, and their phenotypic plasticity is a key contributor to the pathogenesis of various vascular diseases. Two main VSMC phenotypes have been well described: contractile and synthetic. Contractile VSMCs are typically found in the tunica media of the vessel wall, and are responsible for regulating vascular tone and diameter. Synthetic VSMCs, on the other hand, are typically found in the tunica intima and adventitia, and are involved in vascular repair and remodeling. Switching between contractile and synthetic phenotypes occurs in response to various insults and stimuli, such as injury or inflammation, and this allows VSMCs to adapt to changing environmental cues and regulate vascular tone, growth, and repair. Furthermore, VSMCs can also switch to osteoblast‐like and chondrocyte‐like cell phenotypes, which may contribute to vascular calcification and other pathological processes like the formation of atherosclerotic plaques. This provides discusses the mechanisms that regulate VSMC phenotypic switching and its role in the development of vascular diseases. A better understanding of these processes is essential for the development of effective diagnostic and therapeutic strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cellular Physiology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/jcp.31200" target="_blank">https://dx.doi.org/10.1002/jcp.31200</a></p>2024-01-30T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/jcp.31200https://figshare.com/articles/journal_contribution/Phenotypic_switching_of_vascular_smooth_muscle_cells_in_atherosclerosis_hypertension_and_aortic_dissection/29446208CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294462082024-01-30T09:00:00Z |
| spellingShingle | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection Mohamed Elmarasi (14614276) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology aneurysm cardiovascular disease extracellular matrix migration theranostics |
| status_str | publishedVersion |
| title | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| title_full | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| title_fullStr | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| title_full_unstemmed | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| title_short | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| title_sort | Phenotypic switching of vascular smooth muscle cells in atherosclerosis, hypertension, and aortic dissection |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Cardiovascular medicine and haematology aneurysm cardiovascular disease extracellular matrix migration theranostics |