MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes
<div><p>Background: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , , , |
| Published: |
2019
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513520308060160 |
|---|---|
| author | Hassan Dehaini (14689341) |
| author2 | Hussein Awada (3912100) Ahmed El-Yazbi (18174910) Fouad A. Zouein (18174913) Khodr Issa (18174916) Assaad A. Eid (11256112) Maryam Ibrahim (16802799) Adnan Badran (9200140) Elias Baydoun (9200155) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| author2_role | author author author author author author author author author author |
| author_facet | Hassan Dehaini (14689341) Hussein Awada (3912100) Ahmed El-Yazbi (18174910) Fouad A. Zouein (18174913) Khodr Issa (18174916) Assaad A. Eid (11256112) Maryam Ibrahim (16802799) Adnan Badran (9200140) Elias Baydoun (9200155) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hassan Dehaini (14689341) Hussein Awada (3912100) Ahmed El-Yazbi (18174910) Fouad A. Zouein (18174913) Khodr Issa (18174916) Assaad A. Eid (11256112) Maryam Ibrahim (16802799) Adnan Badran (9200140) Elias Baydoun (9200155) Gianfranco Pintus (91638) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2019-02-12T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cells8020152 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/MicroRNAs_as_Potential_Pharmaco-targets_in_Ischemia-Reperfusion_Injury_Compounded_by_Diabetes/25428265 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology pharmaco-targets diabetes ischemia-reperfusion injury microRNA reactive oxygen species apoptosis |
| dc.title.none.fl_str_mv | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Background: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed roles of certain miRNAs in I/R injury, particularly in diabetic conditions and dissect their potential as novel pharmacologic targets in the treatment and management of diabetes. Methods: PubMed was searched for publications containing microRNA and I/R, in the absence or presence of diabetes. All papers that provided sufficient evidence linking miRNA with I/R, especially in the context of diabetes, were selected. Several miRNAs are found to be either pro-apoptotic, as in the case of miR-34a, miR-144, miR-155, and miR-200, or anti-apoptotic, as in the case of miR-210, miR-21, and miR-146a. Here, we further dissect the evidence that shows diverse cell-context dependent effects of these miRNAs, particularly in cardiomyocytes, endothelial, or leukocytes. We also provide insight into cases where the possibility of having two miRNAs working together to intensify a given response is noted. Conclusions: This review arrives at the conclusion that the utilization of miRNAs as translational agents or pharmaco-targets in treating I/R injury in diabetic patients is promising and becoming increasingly clearer.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cells<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8020152" target="_blank">https://dx.doi.org/10.3390/cells8020152</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_268b98a077de3f34fa271b3405a92b34 |
| identifier_str_mv | 10.3390/cells8020152 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25428265 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by DiabetesHassan Dehaini (14689341)Hussein Awada (3912100)Ahmed El-Yazbi (18174910)Fouad A. Zouein (18174913)Khodr Issa (18174916)Assaad A. Eid (11256112)Maryam Ibrahim (16802799)Adnan Badran (9200140)Elias Baydoun (9200155)Gianfranco Pintus (91638)Ali H. Eid (5461829)Biomedical and clinical sciencesCardiovascular medicine and haematologypharmaco-targetsdiabetesischemia-reperfusion injurymicroRNAreactive oxygen speciesapoptosis<div><p>Background: Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), which are currently being heavily studied. This review aims to critically summarize the latest papers that attributed roles of certain miRNAs in I/R injury, particularly in diabetic conditions and dissect their potential as novel pharmacologic targets in the treatment and management of diabetes. Methods: PubMed was searched for publications containing microRNA and I/R, in the absence or presence of diabetes. All papers that provided sufficient evidence linking miRNA with I/R, especially in the context of diabetes, were selected. Several miRNAs are found to be either pro-apoptotic, as in the case of miR-34a, miR-144, miR-155, and miR-200, or anti-apoptotic, as in the case of miR-210, miR-21, and miR-146a. Here, we further dissect the evidence that shows diverse cell-context dependent effects of these miRNAs, particularly in cardiomyocytes, endothelial, or leukocytes. We also provide insight into cases where the possibility of having two miRNAs working together to intensify a given response is noted. Conclusions: This review arrives at the conclusion that the utilization of miRNAs as translational agents or pharmaco-targets in treating I/R injury in diabetic patients is promising and becoming increasingly clearer.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cells<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cells8020152" target="_blank">https://dx.doi.org/10.3390/cells8020152</a></p>2019-02-12T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cells8020152https://figshare.com/articles/journal_contribution/MicroRNAs_as_Potential_Pharmaco-targets_in_Ischemia-Reperfusion_Injury_Compounded_by_Diabetes/25428265CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/254282652019-02-12T03:00:00Z |
| spellingShingle | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes Hassan Dehaini (14689341) Biomedical and clinical sciences Cardiovascular medicine and haematology pharmaco-targets diabetes ischemia-reperfusion injury microRNA reactive oxygen species apoptosis |
| status_str | publishedVersion |
| title | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| title_full | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| title_fullStr | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| title_full_unstemmed | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| title_short | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| title_sort | MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology pharmaco-targets diabetes ischemia-reperfusion injury microRNA reactive oxygen species apoptosis |