Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar
<p dir="ltr">The state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of diabetes, has not yet been described. This study a...
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2020
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| _version_ | 1864513554922602496 |
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| author | Mohamed A. Elrayess (7956179) |
| author2 | Nasser M. Rizk (2029384) Amina S. Fadel (20278113) Abdelhamid Kerkadi (10724304) |
| author2_role | author author author |
| author_facet | Mohamed A. Elrayess (7956179) Nasser M. Rizk (2029384) Amina S. Fadel (20278113) Abdelhamid Kerkadi (10724304) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mohamed A. Elrayess (7956179) Nasser M. Rizk (2029384) Amina S. Fadel (20278113) Abdelhamid Kerkadi (10724304) |
| dc.date.none.fl_str_mv | 2020-07-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijerph17145088 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Prevalence_and_Predictors_of_Insulin_Resistance_in_Non-Obese_Healthy_Young_Females_in_Qatar/27824532 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health non-obese insulin resistance prevalence BMI Qatar |
| dc.title.none.fl_str_mv | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of diabetes, has not yet been described. This study aims to compare the prevalence of insulin resistance in apparently healthy non-obese and obese participants from Qatar and identify the predictors of insulin resistance in different body mass index (BMI)-groups. In this cross-sectional study, 150 young healthy females from Qatar were dichotomized into four groups (underweight, normal weight, overweight and obese) based on their BMI. Anthropometric measures as well as fasting plasma levels of lipids, adipokines, blood glucose and insulin were recorded. The prevalence of insulin resistance as per homeostatic model assessment of insulin resistance (HOMA-IR) was estimated and differences between insulin sensitive and insulin resistant were compared. Linear models were used to identify predictors of insulin resistance in every BMI group. Prevalence of insulin resistance in non-obese healthy females from Qatar ranges between 7% and 37% and increases with BMI. Overall, predictors of insulin resistance in the Qatari population are triglycerides/high-density lipoprotein (HDL) ratio and free fat mass but vary according to the BMI group. The main predictors were triglycerides in normal weight, triglycerides/HDL in overweight and triglycerides/HDL and interleukin-6 (IL-6) in obese individuals. The high prevalence of insulin resistance in non-obese Qataris may partially explain diabetes epidemic. Larger studies are warranted to confirm these findings and identify underlying causes for insulin resistance in non-obese individuals in Qatar, aiming at targeted intervention before diabetes onset.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Environmental Research and Public Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijerph17145088" target="_blank">https://dx.doi.org/10.3390/ijerph17145088</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_27497cd57fa5fc512da49239474e7ce7 |
| identifier_str_mv | 10.3390/ijerph17145088 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27824532 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in QatarMohamed A. Elrayess (7956179)Nasser M. Rizk (2029384)Amina S. Fadel (20278113)Abdelhamid Kerkadi (10724304)Biomedical and clinical sciencesMedical biochemistry and metabolomicsHealth sciencesEpidemiologyPublic healthnon-obeseinsulin resistanceprevalenceBMIQatar<p dir="ltr">The state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of diabetes, has not yet been described. This study aims to compare the prevalence of insulin resistance in apparently healthy non-obese and obese participants from Qatar and identify the predictors of insulin resistance in different body mass index (BMI)-groups. In this cross-sectional study, 150 young healthy females from Qatar were dichotomized into four groups (underweight, normal weight, overweight and obese) based on their BMI. Anthropometric measures as well as fasting plasma levels of lipids, adipokines, blood glucose and insulin were recorded. The prevalence of insulin resistance as per homeostatic model assessment of insulin resistance (HOMA-IR) was estimated and differences between insulin sensitive and insulin resistant were compared. Linear models were used to identify predictors of insulin resistance in every BMI group. Prevalence of insulin resistance in non-obese healthy females from Qatar ranges between 7% and 37% and increases with BMI. Overall, predictors of insulin resistance in the Qatari population are triglycerides/high-density lipoprotein (HDL) ratio and free fat mass but vary according to the BMI group. The main predictors were triglycerides in normal weight, triglycerides/HDL in overweight and triglycerides/HDL and interleukin-6 (IL-6) in obese individuals. The high prevalence of insulin resistance in non-obese Qataris may partially explain diabetes epidemic. Larger studies are warranted to confirm these findings and identify underlying causes for insulin resistance in non-obese individuals in Qatar, aiming at targeted intervention before diabetes onset.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Environmental Research and Public Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijerph17145088" target="_blank">https://dx.doi.org/10.3390/ijerph17145088</a></p>2020-07-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijerph17145088https://figshare.com/articles/journal_contribution/Prevalence_and_Predictors_of_Insulin_Resistance_in_Non-Obese_Healthy_Young_Females_in_Qatar/27824532CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/278245322020-07-15T03:00:00Z |
| spellingShingle | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar Mohamed A. Elrayess (7956179) Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health non-obese insulin resistance prevalence BMI Qatar |
| status_str | publishedVersion |
| title | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| title_full | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| title_fullStr | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| title_full_unstemmed | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| title_short | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| title_sort | Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Health sciences Epidemiology Public health non-obese insulin resistance prevalence BMI Qatar |