Circulating Endothelial Microparticles Reduce in Concentration Following an Exercise Programme in Women With Polycystic Ovary Syndrome
<h3>Purpose</h3><p dir="ltr">Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell derive...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2019
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| الملخص: | <h3>Purpose</h3><p dir="ltr">Endothelial dysfunction is a known comorbidity in women with polycystic ovary syndrome (PCOS). The aim was to assess if supervised, moderate intensity exercise could potentially impact markers of endothelial disruption; endothelial cell derived microparticles (EMP).</p><h3>Methods</h3><p dir="ltr">The current study investigated the effects of a supervised 8-week moderate intensity exercise programme on EMP in women with PCOS (<i>n</i> = 11) and control women free from any known disease (<i>n</i> = 10). EMP were enumerated via specific antibody (CD105, CD106) labeling and flow cytometry.</p><h3>Results</h3><p dir="ltr">CD105+MP significantly reduced in women with PCOS from pre to post-exercise programme, with CD105+ MP reducing from 2114 CD105+ MP per μl platelet free plasma (PFP) to 424 CD105+ MP per μl PFP (<i>p</i> = 0.025). Control women showed no significant change in CD105+ MP (<i>p</i> = 0.25) after completing the same exercise programme. CD106+ MP showed no change in either PCOS (<i>p</i> = 0.95) or control groups (<i>p</i> = 0.99). No significant correlations existed with the changes in EMP compared to body composition changes as a result of exercise.</p><h3>Conclusion</h3><p dir="ltr">Supervised, moderate intensity exercise independent of substantial weight loss reduced circulating CD105+ MP, likely reflecting an improvement in endothelial function in women with PCOS compared to healthy control women. Additionally, EMP may be a useful marker for physical improvement in exercise programmes for clinical populations.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00200" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00200</a></p> |
|---|