Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis
<h3>Introduction</h3><p dir="ltr">Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurre...
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2025
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| _version_ | 1864513533180379136 |
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| author | Abdullah Bin Kamran (22565237) |
| author2 | Ahmed Bazil Bin Khalil (22565240) Ayesha Muhammad (18702111) Hira Arshad (22565243) Fatima Nazir (22565246) Muhammad Mateen Ali (22565249) M. Mairaj Umar (22565252) Muhammad Farhan (4454434) Sudhair Alam (22565255) Javed Iqbal (2121922) |
| author2_role | author author author author author author author author author |
| author_facet | Abdullah Bin Kamran (22565237) Ahmed Bazil Bin Khalil (22565240) Ayesha Muhammad (18702111) Hira Arshad (22565243) Fatima Nazir (22565246) Muhammad Mateen Ali (22565249) M. Mairaj Umar (22565252) Muhammad Farhan (4454434) Sudhair Alam (22565255) Javed Iqbal (2121922) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdullah Bin Kamran (22565237) Ahmed Bazil Bin Khalil (22565240) Ayesha Muhammad (18702111) Hira Arshad (22565243) Fatima Nazir (22565246) Muhammad Mateen Ali (22565249) M. Mairaj Umar (22565252) Muhammad Farhan (4454434) Sudhair Alam (22565255) Javed Iqbal (2121922) |
| dc.date.none.fl_str_mv | 2025-06-10T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/brb3.70508 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Tirofiban_Combination_Therapy_for_Acute_Ischemic_Stroke_A_Systematic_Review_and_Meta_Analysis/30541157 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences acute ischemic stroke antiplatelet therapy dual antiplatelet therapy neurology,stroke tirofiban |
| dc.title.none.fl_str_mv | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent thrombotic events. Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has shown promise as an adjunctive treatment in AIS.</p><h3>Methods</h3><p dir="ltr">A comprehensive search was conducted in PubMed, ClinicalTrials.gov, and Cochrane library from inception to July 2024, following PRISMA guidelines. Inclusion criteria comprised randomized controlled trials (RCTs) and comparative observational studies where tirofiban was used as an adjunct to standard antiplatelet therapy. Primary outcomes included symptomatic intracranial hemorrhage (sICH) and favorable modified Rankin scale (mRS) scores at 90 days. Secondary outcomes included National Institute of Health Stroke Scale (NIHSS) scores and all‐cause mortality. Data was analyzed using Review Manager v5.4.1, with random‐effects models employed for all outcomes.</p><h3>Results</h3><p dir="ltr">Fifteen studies, comprising 4,457 patients, were included. Tirofiban significantly improved the likelihood of achieving favorable mRS scores (OR 1.65, 95% CI [1.29, 2.11], p = 0.0001), with moderate heterogeneity (I<sup>2</sup> = 57%, p = 0.006). Tirofiban also significantly reduced NIHSS scores (MD ‐2.08, 95% CI [‐2.77, ‐1.39], p < 0.00001). There was no significant difference in the incidence of sICH between the tirofiban and control groups.</p><h3>Conclusion</h3><p dir="ltr">Tirofiban as an adjunct to standard antiplatelet therapy in AIS patients significantly improves functional outcomes and reduces neurological impairment without increasing the risk of sICH.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain and Behavior<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/brb3.70508" target="_blank">https://dx.doi.org/10.1002/brb3.70508</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_29dcc6580b0a0bf7f838adc31cf273cb |
| identifier_str_mv | 10.1002/brb3.70508 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30541157 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐AnalysisAbdullah Bin Kamran (22565237)Ahmed Bazil Bin Khalil (22565240)Ayesha Muhammad (18702111)Hira Arshad (22565243)Fatima Nazir (22565246)Muhammad Mateen Ali (22565249)M. Mairaj Umar (22565252)Muhammad Farhan (4454434)Sudhair Alam (22565255)Javed Iqbal (2121922)Biomedical and clinical sciencesCardiovascular medicine and haematologyNeurosciencesPharmacology and pharmaceutical sciencesacute ischemic strokeantiplatelet therapydual antiplatelet therapyneurology,stroketirofiban<h3>Introduction</h3><p dir="ltr">Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent thrombotic events. Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has shown promise as an adjunctive treatment in AIS.</p><h3>Methods</h3><p dir="ltr">A comprehensive search was conducted in PubMed, ClinicalTrials.gov, and Cochrane library from inception to July 2024, following PRISMA guidelines. Inclusion criteria comprised randomized controlled trials (RCTs) and comparative observational studies where tirofiban was used as an adjunct to standard antiplatelet therapy. Primary outcomes included symptomatic intracranial hemorrhage (sICH) and favorable modified Rankin scale (mRS) scores at 90 days. Secondary outcomes included National Institute of Health Stroke Scale (NIHSS) scores and all‐cause mortality. Data was analyzed using Review Manager v5.4.1, with random‐effects models employed for all outcomes.</p><h3>Results</h3><p dir="ltr">Fifteen studies, comprising 4,457 patients, were included. Tirofiban significantly improved the likelihood of achieving favorable mRS scores (OR 1.65, 95% CI [1.29, 2.11], p = 0.0001), with moderate heterogeneity (I<sup>2</sup> = 57%, p = 0.006). Tirofiban also significantly reduced NIHSS scores (MD ‐2.08, 95% CI [‐2.77, ‐1.39], p < 0.00001). There was no significant difference in the incidence of sICH between the tirofiban and control groups.</p><h3>Conclusion</h3><p dir="ltr">Tirofiban as an adjunct to standard antiplatelet therapy in AIS patients significantly improves functional outcomes and reduces neurological impairment without increasing the risk of sICH.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain and Behavior<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/brb3.70508" target="_blank">https://dx.doi.org/10.1002/brb3.70508</a></p>2025-06-10T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/brb3.70508https://figshare.com/articles/journal_contribution/Tirofiban_Combination_Therapy_for_Acute_Ischemic_Stroke_A_Systematic_Review_and_Meta_Analysis/30541157CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/305411572025-06-10T09:00:00Z |
| spellingShingle | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis Abdullah Bin Kamran (22565237) Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences acute ischemic stroke antiplatelet therapy dual antiplatelet therapy neurology,stroke tirofiban |
| status_str | publishedVersion |
| title | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| title_full | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| title_fullStr | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| title_short | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| title_sort | Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Neurosciences Pharmacology and pharmaceutical sciences acute ischemic stroke antiplatelet therapy dual antiplatelet therapy neurology,stroke tirofiban |