MDM2- an indispensable player in tumorigenesis
<p dir="ltr">Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immun...
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2023
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| _version_ | 1864513530898677760 |
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| author | Aasma Zafar (17785652) |
| author2 | Muhammad Jawad Khan (6909224) Aisha Naeem (14157078) |
| author2_role | author author |
| author_facet | Aasma Zafar (17785652) Muhammad Jawad Khan (6909224) Aisha Naeem (14157078) |
| author_role | author |
| dc.creator.none.fl_str_mv | Aasma Zafar (17785652) Muhammad Jawad Khan (6909224) Aisha Naeem (14157078) |
| dc.date.none.fl_str_mv | 2023-06-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11033-023-08512-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/MDM2-_an_indispensable_player_in_tumorigenesis/24995699 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis MDM2 TP53 Apoptosis Cell signaling Metabolism |
| dc.title.none.fl_str_mv | MDM2- an indispensable player in tumorigenesis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been established. Alterations in the expression levels of MDM2 occur in multiple types of cancers resulting in uncontrolled proliferation. The cellular processes are modulated by MDM2 through transcription, post-translational modifications, protein degradation, binding to cofactors, and subcellular localization. In this review, we discuss the precise role of deregulated MDM2 levels in modulating cellular functions to promote cancer growth. Moreover, we also briefly discuss the role of MDM2 in inducing resistance against anti-cancerous therapies thus limiting the benefits of cancerous treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Molecular Biology Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11033-023-08512-3" target="_blank">https://dx.doi.org/10.1007/s11033-023-08512-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2aa18203ee1ec45cf8b80e37d7b351da |
| identifier_str_mv | 10.1007/s11033-023-08512-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24995699 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | MDM2- an indispensable player in tumorigenesisAasma Zafar (17785652)Muhammad Jawad Khan (6909224)Aisha Naeem (14157078)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesisMDM2TP53ApoptosisCell signalingMetabolism<p dir="ltr">Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been established. Alterations in the expression levels of MDM2 occur in multiple types of cancers resulting in uncontrolled proliferation. The cellular processes are modulated by MDM2 through transcription, post-translational modifications, protein degradation, binding to cofactors, and subcellular localization. In this review, we discuss the precise role of deregulated MDM2 levels in modulating cellular functions to promote cancer growth. Moreover, we also briefly discuss the role of MDM2 in inducing resistance against anti-cancerous therapies thus limiting the benefits of cancerous treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Molecular Biology Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s11033-023-08512-3" target="_blank">https://dx.doi.org/10.1007/s11033-023-08512-3</a></p>2023-06-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11033-023-08512-3https://figshare.com/articles/journal_contribution/MDM2-_an_indispensable_player_in_tumorigenesis/24995699CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249956992023-06-01T00:00:00Z |
| spellingShingle | MDM2- an indispensable player in tumorigenesis Aasma Zafar (17785652) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis MDM2 TP53 Apoptosis Cell signaling Metabolism |
| status_str | publishedVersion |
| title | MDM2- an indispensable player in tumorigenesis |
| title_full | MDM2- an indispensable player in tumorigenesis |
| title_fullStr | MDM2- an indispensable player in tumorigenesis |
| title_full_unstemmed | MDM2- an indispensable player in tumorigenesis |
| title_short | MDM2- an indispensable player in tumorigenesis |
| title_sort | MDM2- an indispensable player in tumorigenesis |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis MDM2 TP53 Apoptosis Cell signaling Metabolism |