Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene
<p dir="ltr">MXenes are a family of atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> (MXene) has been re...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2016
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513556507000832 |
|---|---|
| author | Kashif Rasool (2542492) |
| author2 | Mohamed Helal (2542489) Adnan Ali (2542495) Chang E. Ren (4032662) Yury Gogotsi (1280355) Khaled A. Mahmoud (572646) |
| author2_role | author author author author author |
| author_facet | Kashif Rasool (2542492) Mohamed Helal (2542489) Adnan Ali (2542495) Chang E. Ren (4032662) Yury Gogotsi (1280355) Khaled A. Mahmoud (572646) |
| author_role | author |
| dc.creator.none.fl_str_mv | Kashif Rasool (2542492) Mohamed Helal (2542489) Adnan Ali (2542495) Chang E. Ren (4032662) Yury Gogotsi (1280355) Khaled A. Mahmoud (572646) |
| dc.date.none.fl_str_mv | 2016-03-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1021/acsnano.6b00181 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Antibacterial_Activity_of_Ti_sub_3_sub_C_sub_2_sub_T_sub_em_x_em_sub_MXene/27094603 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Materials engineering Environmental sciences Environmental biotechnology MXene Ti3C2Tx antibacterial B. subtilis E. coli membrane oxidative stress |
| dc.title.none.fl_str_mv | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">MXenes are a family of atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> (MXene) has been recently explored for applications in water desalination/purification membranes. A major success indicator for any water treatment membrane is the resistance to biofouling. To validate this and to understand better the health and environmental impacts of the new 2D carbides, we investigated the antibacterial properties of single- and few-layer Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene flakes in colloidal solution. The antibacterial properties of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> were tested against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Bacillus subtilis</i> (<i>B. subtilis</i>) by using bacterial growth curves based on optical densities (OD) and colonies growth on agar nutritive plates. Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> shows a higher antibacterial efficiency toward both Gram-negative <i>E. coli</i> and Gram-positive <i>B. subtilis</i> compared with graphene oxide (GO), which has been widely reported as an antibacterial agent. Concentration dependent antibacterial activity was observed and more than 98% bacterial cell viability loss was found at 200 μg/mL Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> for both bacterial cells within 4 h of exposure, as confirmed by colony forming unit (CFU) and regrowth curve. Antibacterial mechanism investigation by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with lactate dehydrogenase (LDH) release assay indicated the damage to the cell membrane, which resulted in release of cytoplasmic materials from the bacterial cells. Reactive oxygen species (ROS) dependent and independent stress induction by Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> was investigated in two separate abiotic assays. MXenes are expected to be resistant to biofouling and offer bactericidal properties.</p><h2>Other Information</h2><p dir="ltr">Published in: ACS Nano<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1021/acsnano.6b00181" target="_blank">https://dx.doi.org/10.1021/acsnano.6b00181</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2dab9b9e327a6ea35be1209c5c6f6877 |
| identifier_str_mv | 10.1021/acsnano.6b00181 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27094603 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXeneKashif Rasool (2542492)Mohamed Helal (2542489)Adnan Ali (2542495)Chang E. Ren (4032662)Yury Gogotsi (1280355)Khaled A. Mahmoud (572646)EngineeringMaterials engineeringEnvironmental sciencesEnvironmental biotechnologyMXeneTi3C2TxantibacterialB. subtilisE. colimembraneoxidative stress<p dir="ltr">MXenes are a family of atomically thin, two-dimensional (2D) transition metal carbides and carbonitrides with many attractive properties. Two-dimensional Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> (MXene) has been recently explored for applications in water desalination/purification membranes. A major success indicator for any water treatment membrane is the resistance to biofouling. To validate this and to understand better the health and environmental impacts of the new 2D carbides, we investigated the antibacterial properties of single- and few-layer Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene flakes in colloidal solution. The antibacterial properties of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> were tested against <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Bacillus subtilis</i> (<i>B. subtilis</i>) by using bacterial growth curves based on optical densities (OD) and colonies growth on agar nutritive plates. Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> shows a higher antibacterial efficiency toward both Gram-negative <i>E. coli</i> and Gram-positive <i>B. subtilis</i> compared with graphene oxide (GO), which has been widely reported as an antibacterial agent. Concentration dependent antibacterial activity was observed and more than 98% bacterial cell viability loss was found at 200 μg/mL Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> for both bacterial cells within 4 h of exposure, as confirmed by colony forming unit (CFU) and regrowth curve. Antibacterial mechanism investigation by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with lactate dehydrogenase (LDH) release assay indicated the damage to the cell membrane, which resulted in release of cytoplasmic materials from the bacterial cells. Reactive oxygen species (ROS) dependent and independent stress induction by Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> was investigated in two separate abiotic assays. MXenes are expected to be resistant to biofouling and offer bactericidal properties.</p><h2>Other Information</h2><p dir="ltr">Published in: ACS Nano<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.1021/acsnano.6b00181" target="_blank">https://dx.doi.org/10.1021/acsnano.6b00181</a></p>2016-03-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1021/acsnano.6b00181https://figshare.com/articles/journal_contribution/Antibacterial_Activity_of_Ti_sub_3_sub_C_sub_2_sub_T_sub_em_x_em_sub_MXene/27094603CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270946032016-03-01T00:00:00Z |
| spellingShingle | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene Kashif Rasool (2542492) Engineering Materials engineering Environmental sciences Environmental biotechnology MXene Ti3C2Tx antibacterial B. subtilis E. coli membrane oxidative stress |
| status_str | publishedVersion |
| title | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| title_full | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| title_fullStr | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| title_full_unstemmed | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| title_short | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| title_sort | Antibacterial Activity of Ti<sub>3</sub>C<sub>2</sub>T<sub><em>x</em></sub> MXene |
| topic | Engineering Materials engineering Environmental sciences Environmental biotechnology MXene Ti3C2Tx antibacterial B. subtilis E. coli membrane oxidative stress |