Inositol 1,4,5-Trisphosphate Receptors in Hypertension
<p dir="ltr">Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in...
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| author | Ali H. Eid (5461829) |
| author2 | Ahmed F. El-Yazbi (10180589) Fouad Zouein (18091168) Abdelilah Arredouani (10914455) Allal Ouhtit (526) Md M. Rahman (14152977) Hatem Zayed (835448) Gianfranco Pintus (91638) Haissam Abou-Saleh (497840) |
| author2_role | author author author author author author author author |
| author_facet | Ali H. Eid (5461829) Ahmed F. El-Yazbi (10180589) Fouad Zouein (18091168) Abdelilah Arredouani (10914455) Allal Ouhtit (526) Md M. Rahman (14152977) Hatem Zayed (835448) Gianfranco Pintus (91638) Haissam Abou-Saleh (497840) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ali H. Eid (5461829) Ahmed F. El-Yazbi (10180589) Fouad Zouein (18091168) Abdelilah Arredouani (10914455) Allal Ouhtit (526) Md M. Rahman (14152977) Hatem Zayed (835448) Gianfranco Pintus (91638) Haissam Abou-Saleh (497840) |
| dc.date.none.fl_str_mv | 2018-07-26T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fphys.2018.01018 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Inositol_1_4_5-Trisphosphate_Receptors_in_Hypertension/25331323 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical physiology aging hypertension Ca2+ IP3R VSMC |
| dc.title.none.fl_str_mv | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca<sup>2+</sup>]<sub><em>i</em></sub>) are mediated either by the influx of Ca<sup>2+</sup> from the extracellular space or release of Ca<sup>2+</sup> from intracellular stores, mainly the sarcoplasmic reticulum (SR). The influx of extracellular Ca<sup>2+</sup> occurs primarily through voltage-gated Ca<sup>2+</sup> channels (VGCCs), store-operated Ca<sup>2+</sup> channels (SOC), and Ca<sup>2+</sup> release-activated channels (CRAC), whereas SR-Ca<sup>2+</sup> release occurs through inositol trisphosphate receptor (IP<sub>3</sub>R) and ryanodine receptors (RyRs). IP<sub>3</sub>R-mediated SR-Ca<sup>2+</sup> release, in the form of Ca<sup>2+</sup> waves, not only contributes to VSMC contraction and regulates VGCC function but is also intimately involved in structural remodeling of resistance arteries in hypertension. This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. The present review discusses the current knowledge of these mechanisms in an integrative approach and further suggests potential new targets for hypertension management and treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Physiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphys.2018.01018" target="_blank">https://dx.doi.org/10.3389/fphys.2018.01018</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2e3418717c65b6fe3892b9867f31282e |
| identifier_str_mv | 10.3389/fphys.2018.01018 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25331323 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Inositol 1,4,5-Trisphosphate Receptors in HypertensionAli H. Eid (5461829)Ahmed F. El-Yazbi (10180589)Fouad Zouein (18091168)Abdelilah Arredouani (10914455)Allal Ouhtit (526)Md M. Rahman (14152977)Hatem Zayed (835448)Gianfranco Pintus (91638)Haissam Abou-Saleh (497840)Biomedical and clinical sciencesMedical physiologyaginghypertensionCa2+IP3RVSMC<p dir="ltr">Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function together with an alteration in vascular smooth muscle cells (VSMCs) calcium homeostasis leading to increased myogenic tone. Changes in free intracellular calcium levels ([Ca<sup>2+</sup>]<sub><em>i</em></sub>) are mediated either by the influx of Ca<sup>2+</sup> from the extracellular space or release of Ca<sup>2+</sup> from intracellular stores, mainly the sarcoplasmic reticulum (SR). The influx of extracellular Ca<sup>2+</sup> occurs primarily through voltage-gated Ca<sup>2+</sup> channels (VGCCs), store-operated Ca<sup>2+</sup> channels (SOC), and Ca<sup>2+</sup> release-activated channels (CRAC), whereas SR-Ca<sup>2+</sup> release occurs through inositol trisphosphate receptor (IP<sub>3</sub>R) and ryanodine receptors (RyRs). IP<sub>3</sub>R-mediated SR-Ca<sup>2+</sup> release, in the form of Ca<sup>2+</sup> waves, not only contributes to VSMC contraction and regulates VGCC function but is also intimately involved in structural remodeling of resistance arteries in hypertension. This involves a phenotypic switch of VSMCs as well as an alteration of cytoplasmic Ca<sup>2+</sup> signaling machinery, a phenomena tightly related to the aging process. Several lines of evidence implicate changes in expression/function levels of IP<sub>3</sub>R isoforms in the development of hypertension, VSMC phenotypic switch, and vascular aging. The present review discusses the current knowledge of these mechanisms in an integrative approach and further suggests potential new targets for hypertension management and treatment.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Physiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphys.2018.01018" target="_blank">https://dx.doi.org/10.3389/fphys.2018.01018</a></p>2018-07-26T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fphys.2018.01018https://figshare.com/articles/journal_contribution/Inositol_1_4_5-Trisphosphate_Receptors_in_Hypertension/25331323CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253313232018-07-26T03:00:00Z |
| spellingShingle | Inositol 1,4,5-Trisphosphate Receptors in Hypertension Ali H. Eid (5461829) Biomedical and clinical sciences Medical physiology aging hypertension Ca2+ IP3R VSMC |
| status_str | publishedVersion |
| title | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| title_full | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| title_fullStr | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| title_full_unstemmed | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| title_short | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| title_sort | Inositol 1,4,5-Trisphosphate Receptors in Hypertension |
| topic | Biomedical and clinical sciences Medical physiology aging hypertension Ca2+ IP3R VSMC |