The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study
<p dir="ltr">The Middle East region experiences a high prevalence of vitamin D deficiency, yet most genetic studies on vitamin D have focused on European populations. Furthermore, there is a lack of research on the genomic risk factors affecting elderly people, who are more susceptib...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2023
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| _version_ | 1864513520743219200 |
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| author | Nagham Nafiz Hendi (17064261) |
| author2 | Marlene Chakhtoura (12398227) Yasser Al-Sarraj (11721425) Dania Saleh Basha (19438309) Omar Albagha (8977856) Ghada El-Hajj Fuleihan (19438312) Georges Nemer (295984) |
| author2_role | author author author author author author |
| author_facet | Nagham Nafiz Hendi (17064261) Marlene Chakhtoura (12398227) Yasser Al-Sarraj (11721425) Dania Saleh Basha (19438309) Omar Albagha (8977856) Ghada El-Hajj Fuleihan (19438312) Georges Nemer (295984) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nagham Nafiz Hendi (17064261) Marlene Chakhtoura (12398227) Yasser Al-Sarraj (11721425) Dania Saleh Basha (19438309) Omar Albagha (8977856) Ghada El-Hajj Fuleihan (19438312) Georges Nemer (295984) |
| dc.date.none.fl_str_mv | 2023-07-20T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/nu15143216 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Genetic_Architecture_of_Vitamin_D_Deficiency_among_an_Elderly_Lebanese_Middle_Eastern_Population_An_Exome-Wide_Association_Study/26776498 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology exome-wide association study vitamin D deficiency genetic determinants polygenic risk score Middle Eastern population |
| dc.title.none.fl_str_mv | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The Middle East region experiences a high prevalence of vitamin D deficiency, yet most genetic studies on vitamin D have focused on European populations. Furthermore, there is a lack of research on the genomic risk factors affecting elderly people, who are more susceptible to health burdens. We investigated the genetic determinants of 25-hydroxyvitamin D concentrations in elderly Lebanese individuals (<i>n</i> = 199) through a whole-exome-based genome-wide association study. Novel genomic loci displaying suggestive evidence of association with 25-hydroxyvitamin D levels were identified in our study, including rs141064014 in the <i>MGAM</i> (p-value of 4.40 × 10<sup>−6</sup>) and rs7036592 in <i>PHF2</i> (<i>p</i>-value of 8.43 × 10<sup>−6</sup>). A meta-analysis of the Lebanese data and the largest European genome-wide association study confirmed consistency replication of numerous variants, including rs2725405 in <i>SLC</i>38A10 (<i>p</i>-value of 3.73 × 10<sup>−8</sup>). Although the polygenic risk score model derived from European populations exhibited lower performance than European estimations, it still effectively predicted vitamin D deficiency among our cohort. Our discoveries offer novel perspectives on the genetic mechanisms underlying vitamin D deficiency among elderly Middle Eastern populations, facilitating the development of personalized approaches for more effective management of vitamin D deficiency. Additionally, we demonstrated that whole-exome-based genome-wide association study is an effective method for identifying genetic components associated with phenotypes.</p><h2>Other Information</h2><p dir="ltr">Published in: Nutrients<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/nu15143216" target="_blank">https://dx.doi.org/10.3390/nu15143216</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2eb126fc800b356ee406bfc32c7c3959 |
| identifier_str_mv | 10.3390/nu15143216 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26776498 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association StudyNagham Nafiz Hendi (17064261)Marlene Chakhtoura (12398227)Yasser Al-Sarraj (11721425)Dania Saleh Basha (19438309)Omar Albagha (8977856)Ghada El-Hajj Fuleihan (19438312)Georges Nemer (295984)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesHealth sciencesEpidemiologyexome-wide association studyvitamin D deficiencygenetic determinantspolygenic risk scoreMiddle Eastern population<p dir="ltr">The Middle East region experiences a high prevalence of vitamin D deficiency, yet most genetic studies on vitamin D have focused on European populations. Furthermore, there is a lack of research on the genomic risk factors affecting elderly people, who are more susceptible to health burdens. We investigated the genetic determinants of 25-hydroxyvitamin D concentrations in elderly Lebanese individuals (<i>n</i> = 199) through a whole-exome-based genome-wide association study. Novel genomic loci displaying suggestive evidence of association with 25-hydroxyvitamin D levels were identified in our study, including rs141064014 in the <i>MGAM</i> (p-value of 4.40 × 10<sup>−6</sup>) and rs7036592 in <i>PHF2</i> (<i>p</i>-value of 8.43 × 10<sup>−6</sup>). A meta-analysis of the Lebanese data and the largest European genome-wide association study confirmed consistency replication of numerous variants, including rs2725405 in <i>SLC</i>38A10 (<i>p</i>-value of 3.73 × 10<sup>−8</sup>). Although the polygenic risk score model derived from European populations exhibited lower performance than European estimations, it still effectively predicted vitamin D deficiency among our cohort. Our discoveries offer novel perspectives on the genetic mechanisms underlying vitamin D deficiency among elderly Middle Eastern populations, facilitating the development of personalized approaches for more effective management of vitamin D deficiency. Additionally, we demonstrated that whole-exome-based genome-wide association study is an effective method for identifying genetic components associated with phenotypes.</p><h2>Other Information</h2><p dir="ltr">Published in: Nutrients<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/nu15143216" target="_blank">https://dx.doi.org/10.3390/nu15143216</a></p>2023-07-20T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/nu15143216https://figshare.com/articles/journal_contribution/The_Genetic_Architecture_of_Vitamin_D_Deficiency_among_an_Elderly_Lebanese_Middle_Eastern_Population_An_Exome-Wide_Association_Study/26776498CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/267764982023-07-20T09:00:00Z |
| spellingShingle | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study Nagham Nafiz Hendi (17064261) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology exome-wide association study vitamin D deficiency genetic determinants polygenic risk score Middle Eastern population |
| status_str | publishedVersion |
| title | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| title_full | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| title_fullStr | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| title_full_unstemmed | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| title_short | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| title_sort | The Genetic Architecture of Vitamin D Deficiency among an Elderly Lebanese Middle Eastern Population: An Exome-Wide Association Study |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Health sciences Epidemiology exome-wide association study vitamin D deficiency genetic determinants polygenic risk score Middle Eastern population |