Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
<p dir="ltr">Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer....
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2024
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| _version_ | 1864513545088008192 |
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| author | Menatallah Rayan (14151360) |
| author2 | Tahseen S. Sayed (14724824) Ola J. Hussein (17346952) Lubna Therachiyil (4246156) Zaid H. Maayah (9236533) Cristina Maccalli (2632465) Shahab Uddin (154400) Jochen H. M. Prehn (7034570) Hesham M. Korashy (1474849) |
| author2_role | author author author author author author author author |
| author_facet | Menatallah Rayan (14151360) Tahseen S. Sayed (14724824) Ola J. Hussein (17346952) Lubna Therachiyil (4246156) Zaid H. Maayah (9236533) Cristina Maccalli (2632465) Shahab Uddin (154400) Jochen H. M. Prehn (7034570) Hesham M. Korashy (1474849) |
| author_role | author |
| dc.creator.none.fl_str_mv | Menatallah Rayan (14151360) Tahseen S. Sayed (14724824) Ola J. Hussein (17346952) Lubna Therachiyil (4246156) Zaid H. Maayah (9236533) Cristina Maccalli (2632465) Shahab Uddin (154400) Jochen H. M. Prehn (7034570) Hesham M. Korashy (1474849) |
| dc.date.none.fl_str_mv | 2024-03-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s11658-024-00538-0 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Unlocking_the_secrets_exploring_the_influence_of_the_aryl_hydrocarbon_receptor_and_microbiome_on_cancer_development/29446067 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Epidemiology Microbiome Aryl hydrocarbon receptor Cancer CYP1A1 Environmental pollutants |
| dc.title.none.fl_str_mv | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organs, thereby influencing the clinical outcome of cancer patients. The gut microbiome has recently been reported to interact with environmental factors such as diet and exposure to environmental toxicants. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) induces a shift in the gut microbiome metabolic pathways, favoring a proinflammatory microenvironment. In addition, other studies have also correlated cancer incidence with exposure to PAHs. PAHs are known to induce organ carcinogenesis through activating a ligand-activated transcriptional factor termed the aryl hydrocarbon receptor (AhR), which metabolizes PAHs to highly reactive carcinogenic intermediates. However, the crosstalk between AhR and the microbiome in mediating carcinogenesis is poorly reviewed. This review aims to discuss the role of exposure to environmental pollutants and activation of AhR on microbiome-associated cancer progression and explore the underlying molecular mechanisms involved in cancer development.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular & Molecular Biology Letters<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s11658-024-00538-0" target="_blank">https://dx.doi.org/10.1186/s11658-024-00538-0</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_2fc21ae0f56302c237bc6ccfc1777b01 |
| identifier_str_mv | 10.1186/s11658-024-00538-0 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29446067 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer developmentMenatallah Rayan (14151360)Tahseen S. Sayed (14724824)Ola J. Hussein (17346952)Lubna Therachiyil (4246156)Zaid H. Maayah (9236533)Cristina Maccalli (2632465)Shahab Uddin (154400)Jochen H. M. Prehn (7034570)Hesham M. Korashy (1474849)Biomedical and clinical sciencesOncology and carcinogenesisHealth sciencesEpidemiologyMicrobiomeAryl hydrocarbon receptorCancerCYP1A1Environmental pollutants<p dir="ltr">Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurations with the occurrence of several diseases, including cancer. Accumulating evidence suggests that the microbiome can influence the initiation and progression of several cancers. Moreover, some microbiotas of the gut and oral cavity have been reported to infect tumors, initiate metastasis, and promote the spread of cancer to distant organs, thereby influencing the clinical outcome of cancer patients. The gut microbiome has recently been reported to interact with environmental factors such as diet and exposure to environmental toxicants. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) induces a shift in the gut microbiome metabolic pathways, favoring a proinflammatory microenvironment. In addition, other studies have also correlated cancer incidence with exposure to PAHs. PAHs are known to induce organ carcinogenesis through activating a ligand-activated transcriptional factor termed the aryl hydrocarbon receptor (AhR), which metabolizes PAHs to highly reactive carcinogenic intermediates. However, the crosstalk between AhR and the microbiome in mediating carcinogenesis is poorly reviewed. This review aims to discuss the role of exposure to environmental pollutants and activation of AhR on microbiome-associated cancer progression and explore the underlying molecular mechanisms involved in cancer development.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular & Molecular Biology Letters<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s11658-024-00538-0" target="_blank">https://dx.doi.org/10.1186/s11658-024-00538-0</a></p>2024-03-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s11658-024-00538-0https://figshare.com/articles/journal_contribution/Unlocking_the_secrets_exploring_the_influence_of_the_aryl_hydrocarbon_receptor_and_microbiome_on_cancer_development/29446067CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/294460672024-03-06T03:00:00Z |
| spellingShingle | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development Menatallah Rayan (14151360) Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Epidemiology Microbiome Aryl hydrocarbon receptor Cancer CYP1A1 Environmental pollutants |
| status_str | publishedVersion |
| title | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_full | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_fullStr | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_full_unstemmed | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_short | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| title_sort | Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Health sciences Epidemiology Microbiome Aryl hydrocarbon receptor Cancer CYP1A1 Environmental pollutants |