Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers
<p dir="ltr">The interplay between microRNAs (miRNAs) and pluripotency transcription factors (TFs) orchestrates the acquisition of cancer stem cell (CSC) features during the course of malignant transformation, rendering them essential cancer cell dependencies and therapeutic vulnerab...
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2022
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| _version_ | 1864513537544552448 |
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| author | Radhakrishnan Vishnubalaji (3563306) |
| author2 | Hibah Shaath (5599658) Monther Al-Alwan (197831) Essam M. Abdelalim (5768072) Nehad M. Alajez (7397276) |
| author2_role | author author author author |
| author_facet | Radhakrishnan Vishnubalaji (3563306) Hibah Shaath (5599658) Monther Al-Alwan (197831) Essam M. Abdelalim (5768072) Nehad M. Alajez (7397276) |
| author_role | author |
| dc.creator.none.fl_str_mv | Radhakrishnan Vishnubalaji (3563306) Hibah Shaath (5599658) Monther Al-Alwan (197831) Essam M. Abdelalim (5768072) Nehad M. Alajez (7397276) |
| dc.date.none.fl_str_mv | 2022-12-01T21:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2022.10.007 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Reciprocal_interplays_between_MicroRNAs_and_pluripotency_transcription_factors_in_dictating_stemness_features_in_human_cancers/24516439 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biotechnology Oncology and carcinogenesis Transcription factors MYC OCT4 NANOG SOX2 KLF4 CSCs MiRNA MiRNA-TF networks Cancer |
| dc.title.none.fl_str_mv | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The interplay between microRNAs (miRNAs) and pluripotency transcription factors (TFs) orchestrates the acquisition of cancer stem cell (CSC) features during the course of malignant transformation, rendering them essential cancer cell dependencies and therapeutic vulnerabilities. In this review, we discuss emerging themes in tumor heterogeneity, including the clonal evolution and the CSC models and their implications in resistance to cancer therapies, and then provide thorough coverage on the roles played by key TFs in maintaining normal and malignant stem cell pluripotency and plasticity. In addition, we discuss the reciprocal interactions between miRNAs and MYC, OCT4, NANOG, SOX2, and KLF4 pluripotency TFs and their contributions to tumorigenesis. We provide our view on the potential to interfere with key miRNA-TF networks through the use of RNA-based therapeutics as single agents or in combination with other therapeutic strategies, to abrogate the CSC state and render tumor cells more responsive to standard and targeted therapies.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.10.007" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.10.007</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3139e071e9ce3b67d389c63adb615996 |
| identifier_str_mv | 10.1016/j.semcancer.2022.10.007 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24516439 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancersRadhakrishnan Vishnubalaji (3563306)Hibah Shaath (5599658)Monther Al-Alwan (197831)Essam M. Abdelalim (5768072)Nehad M. Alajez (7397276)Biomedical and clinical sciencesClinical sciencesMedical biotechnologyOncology and carcinogenesisTranscription factorsMYCOCT4NANOGSOX2KLF4CSCsMiRNAMiRNA-TF networksCancer<p dir="ltr">The interplay between microRNAs (miRNAs) and pluripotency transcription factors (TFs) orchestrates the acquisition of cancer stem cell (CSC) features during the course of malignant transformation, rendering them essential cancer cell dependencies and therapeutic vulnerabilities. In this review, we discuss emerging themes in tumor heterogeneity, including the clonal evolution and the CSC models and their implications in resistance to cancer therapies, and then provide thorough coverage on the roles played by key TFs in maintaining normal and malignant stem cell pluripotency and plasticity. In addition, we discuss the reciprocal interactions between miRNAs and MYC, OCT4, NANOG, SOX2, and KLF4 pluripotency TFs and their contributions to tumorigenesis. We provide our view on the potential to interfere with key miRNA-TF networks through the use of RNA-based therapeutics as single agents or in combination with other therapeutic strategies, to abrogate the CSC state and render tumor cells more responsive to standard and targeted therapies.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2022.10.007" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2022.10.007</a></p>2022-12-01T21:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2022.10.007https://figshare.com/articles/journal_contribution/Reciprocal_interplays_between_MicroRNAs_and_pluripotency_transcription_factors_in_dictating_stemness_features_in_human_cancers/24516439CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245164392022-12-01T21:00:00Z |
| spellingShingle | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers Radhakrishnan Vishnubalaji (3563306) Biomedical and clinical sciences Clinical sciences Medical biotechnology Oncology and carcinogenesis Transcription factors MYC OCT4 NANOG SOX2 KLF4 CSCs MiRNA MiRNA-TF networks Cancer |
| status_str | publishedVersion |
| title | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| title_full | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| title_fullStr | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| title_full_unstemmed | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| title_short | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| title_sort | Reciprocal interplays between MicroRNAs and pluripotency transcription factors in dictating stemness features in human cancers |
| topic | Biomedical and clinical sciences Clinical sciences Medical biotechnology Oncology and carcinogenesis Transcription factors MYC OCT4 NANOG SOX2 KLF4 CSCs MiRNA MiRNA-TF networks Cancer |