Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
<div><p>Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the ab...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2019
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إضافة وسم
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| _version_ | 1864513523109855232 |
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| author | Rasha M. Sareyeldin (18131371) |
| author2 | Ishita Gupta (9203073) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema F. Al Farsi (18131380) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author2_role | author author author author author author |
| author_facet | Rasha M. Sareyeldin (18131371) Ishita Gupta (9203073) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema F. Al Farsi (18131380) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| author_role | author |
| dc.creator.none.fl_str_mv | Rasha M. Sareyeldin (18131371) Ishita Gupta (9203073) Israa Al-Hashimi (18131374) Hamda A. Al-Thawadi (18131377) Halema F. Al Farsi (18131380) Semir Vranic (3353012) Ala-Eddin Al Moustafa (14153205) |
| dc.date.none.fl_str_mv | 2019-05-10T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers11050646 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Gene_Expression_and_miRNAs_Profiling_Function_and_Regulation_in_Human_Epidermal_Growth_Factor_Receptor_2_HER2_-Positive_Breast_Cancer/25376245 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis breast cancer HER2-positive breast cancer biomarkers microarray gene expression profiling miRNAs |
| dc.title.none.fl_str_mv | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15–20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers11050646" target="_blank">https://dx.doi.org/10.3390/cancers11050646</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_32a9cfa235596ed0a15c3d2ff79cad99 |
| identifier_str_mv | 10.3390/cancers11050646 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25376245 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast CancerRasha M. Sareyeldin (18131371)Ishita Gupta (9203073)Israa Al-Hashimi (18131374)Hamda A. Al-Thawadi (18131377)Halema F. Al Farsi (18131380)Semir Vranic (3353012)Ala-Eddin Al Moustafa (14153205)Biomedical and clinical sciencesOncology and carcinogenesisbreast cancerHER2-positive breast cancerbiomarkersmicroarraygene expression profilingmiRNAs<div><p>Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 (HER2)-enriched (HER2-positive) is characterized by the absence of estrogen and progesterone receptors and overexpression of HER2 receptor, and accounts for 15–20% of all breast cancers. Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. This review focuses on recent advances on gene expression and miRNA status in HER2-positive breast cancer.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers11050646" target="_blank">https://dx.doi.org/10.3390/cancers11050646</a></p>2019-05-10T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers11050646https://figshare.com/articles/journal_contribution/Gene_Expression_and_miRNAs_Profiling_Function_and_Regulation_in_Human_Epidermal_Growth_Factor_Receptor_2_HER2_-Positive_Breast_Cancer/25376245CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253762452019-05-10T03:00:00Z |
| spellingShingle | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Rasha M. Sareyeldin (18131371) Biomedical and clinical sciences Oncology and carcinogenesis breast cancer HER2-positive breast cancer biomarkers microarray gene expression profiling miRNAs |
| status_str | publishedVersion |
| title | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| title_full | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| title_fullStr | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| title_full_unstemmed | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| title_short | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| title_sort | Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis breast cancer HER2-positive breast cancer biomarkers microarray gene expression profiling miRNAs |