Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis
<h3>Objectives</h3><p dir="ltr">This study aims to evaluate the efficacy of Apnex, Inspire, and ImThera hypoglossal nerve stimulation (HGNS) devices in changing the severity of obstructive sleep apnea (OSA). </p><h3>Methodology</h3><p dir="ltr&qu...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513540070572032 |
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| author | Warda A. Alrubasy (18021700) |
| author2 | Mohammad T. Abuawwad (17632242) Mohammad J.J. Taha (22224706) Mohammed Khurais (22224709) Muhammad Sabrah Sayed (22224712) Amneh M. Dahik (22224715) Noha Keshk (20316755) Sameh Abdelhadi (22224718) Hashem Abu Serhan (15993651) |
| author2_role | author author author author author author author author |
| author_facet | Warda A. Alrubasy (18021700) Mohammad T. Abuawwad (17632242) Mohammad J.J. Taha (22224706) Mohammed Khurais (22224709) Muhammad Sabrah Sayed (22224712) Amneh M. Dahik (22224715) Noha Keshk (20316755) Sameh Abdelhadi (22224718) Hashem Abu Serhan (15993651) |
| author_role | author |
| dc.creator.none.fl_str_mv | Warda A. Alrubasy (18021700) Mohammad T. Abuawwad (17632242) Mohammad J.J. Taha (22224706) Mohammed Khurais (22224709) Muhammad Sabrah Sayed (22224712) Amneh M. Dahik (22224715) Noha Keshk (20316755) Sameh Abdelhadi (22224718) Hashem Abu Serhan (15993651) |
| dc.date.none.fl_str_mv | 2024-10-17T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.rmed.2024.107826 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hypoglossal_nerve_stimulation_for_obstructive_sleep_apnea_in_adults_An_updated_systematic_review_and_meta-analysis/30094573 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Neurosciences Hypoglossal nerve stimulation Upper airway stimulation Obstructive sleep apnea Sleep hypopnea Sleep-disordered breathing |
| dc.title.none.fl_str_mv | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objectives</h3><p dir="ltr">This study aims to evaluate the efficacy of Apnex, Inspire, and ImThera hypoglossal nerve stimulation (HGNS) devices in changing the severity of obstructive sleep apnea (OSA). </p><h3>Methodology</h3><p dir="ltr">A systematic search was conducted across the databases to collect baseline and postoperative outcome measures. Articles were then filtered and data from post-filtration was extracted. The efficacy of each device was assessed individually, and the reported outcomes were analyzed at short-term (≤1 year) and long-term (>1 year) intervals. </p><h3>Results</h3><p dir="ltr">A total of 30 papers were included; 26 were single-arm studies encompassing 549 middle-aged overweight patients. Four RCTs included 273 participants. Results show that HGNS is an effective and safe treatment option. The Inspire device significantly improved, reducing the apnea-hypopnea index (AHI) by −20.14 events/h in the short term and −15.91 events/h in the long term. It also decreased the oxygen desaturation index (ODI) by −14.16 events/h (short term) and −12.95 events/h (long term). Patient-reported outcomes showed decreased Epworth Sleepiness Scale (ESS) scores by −5.02 (short term) and −4.90 (long term) and improved Functional Outcomes of Sleep Questionnaire (FOSQ) scores by 3.58 (short term) and 3.28 (long term). The Apnex and the ImThera devices featured similar improvements but to a lesser extent. </p><h3>Conclusion</h3><p dir="ltr">Hypoglossal nerve stimulation is a safe and effective treatment for patients with OSA, exhibiting high adherence and satisfaction rates. However, it is important to note the potential for refining selection criteria to include a wider spectrum of patients with OSA.</p><h2>Other Information</h2><p dir="ltr">Published in: Respiratory Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.rmed.2024.107826" target="_blank">https://dx.doi.org/10.1016/j.rmed.2024.107826</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_32f666f044fcdf9469333da33a024223 |
| identifier_str_mv | 10.1016/j.rmed.2024.107826 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30094573 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysisWarda A. Alrubasy (18021700)Mohammad T. Abuawwad (17632242)Mohammad J.J. Taha (22224706)Mohammed Khurais (22224709)Muhammad Sabrah Sayed (22224712)Amneh M. Dahik (22224715)Noha Keshk (20316755)Sameh Abdelhadi (22224718)Hashem Abu Serhan (15993651)Biomedical and clinical sciencesClinical sciencesNeurosciencesHypoglossal nerve stimulationUpper airway stimulationObstructive sleep apneaSleep hypopneaSleep-disordered breathing<h3>Objectives</h3><p dir="ltr">This study aims to evaluate the efficacy of Apnex, Inspire, and ImThera hypoglossal nerve stimulation (HGNS) devices in changing the severity of obstructive sleep apnea (OSA). </p><h3>Methodology</h3><p dir="ltr">A systematic search was conducted across the databases to collect baseline and postoperative outcome measures. Articles were then filtered and data from post-filtration was extracted. The efficacy of each device was assessed individually, and the reported outcomes were analyzed at short-term (≤1 year) and long-term (>1 year) intervals. </p><h3>Results</h3><p dir="ltr">A total of 30 papers were included; 26 were single-arm studies encompassing 549 middle-aged overweight patients. Four RCTs included 273 participants. Results show that HGNS is an effective and safe treatment option. The Inspire device significantly improved, reducing the apnea-hypopnea index (AHI) by −20.14 events/h in the short term and −15.91 events/h in the long term. It also decreased the oxygen desaturation index (ODI) by −14.16 events/h (short term) and −12.95 events/h (long term). Patient-reported outcomes showed decreased Epworth Sleepiness Scale (ESS) scores by −5.02 (short term) and −4.90 (long term) and improved Functional Outcomes of Sleep Questionnaire (FOSQ) scores by 3.58 (short term) and 3.28 (long term). The Apnex and the ImThera devices featured similar improvements but to a lesser extent. </p><h3>Conclusion</h3><p dir="ltr">Hypoglossal nerve stimulation is a safe and effective treatment for patients with OSA, exhibiting high adherence and satisfaction rates. However, it is important to note the potential for refining selection criteria to include a wider spectrum of patients with OSA.</p><h2>Other Information</h2><p dir="ltr">Published in: Respiratory Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.rmed.2024.107826" target="_blank">https://dx.doi.org/10.1016/j.rmed.2024.107826</a></p>2024-10-17T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.rmed.2024.107826https://figshare.com/articles/journal_contribution/Hypoglossal_nerve_stimulation_for_obstructive_sleep_apnea_in_adults_An_updated_systematic_review_and_meta-analysis/30094573CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/300945732024-10-17T15:00:00Z |
| spellingShingle | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis Warda A. Alrubasy (18021700) Biomedical and clinical sciences Clinical sciences Neurosciences Hypoglossal nerve stimulation Upper airway stimulation Obstructive sleep apnea Sleep hypopnea Sleep-disordered breathing |
| status_str | publishedVersion |
| title | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| title_full | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| title_fullStr | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| title_full_unstemmed | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| title_short | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| title_sort | Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis |
| topic | Biomedical and clinical sciences Clinical sciences Neurosciences Hypoglossal nerve stimulation Upper airway stimulation Obstructive sleep apnea Sleep hypopnea Sleep-disordered breathing |