Exploring the potential of microRNA as a diagnostic tool for gestational diabetes
<div><p>MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of miRNAs in the pathogenesis of gestational diabetes mellitus (GDM), a common pregnancy-related disorder characterized by impaired gluco...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| منشور في: |
2023
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513526556524544 |
|---|---|
| author | Duaa Ahmed Elhag (10227875) |
| author2 | Souhaila Al Khodor (89983) |
| author2_role | author |
| author_facet | Duaa Ahmed Elhag (10227875) Souhaila Al Khodor (89983) |
| author_role | author |
| dc.creator.none.fl_str_mv | Duaa Ahmed Elhag (10227875) Souhaila Al Khodor (89983) |
| dc.date.none.fl_str_mv | 2023-06-17T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-023-04269-2 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Exploring_the_potential_of_microRNA_as_a_diagnostic_tool_for_gestational_diabetes/25257166 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Diabetes OGTT Pregnancy complications BMI Macrosomia |
| dc.title.none.fl_str_mv | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of miRNAs in the pathogenesis of gestational diabetes mellitus (GDM), a common pregnancy-related disorder characterized by impaired glucose metabolism. Aberrant expression of miRNAs has been observed in the placenta and/or maternal blood of GDM patients, suggesting their potential use as biomarkers for early diagnosis and prognosis. Additionally, several miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM as well as their potential as diagnostic and therapeutic targets.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Translational Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-023-04269-2" target="_blank">https://dx.doi.org/10.1186/s12967-023-04269-2</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_332d76f9c8b33d908bc93f285a0150ed |
| identifier_str_mv | 10.1186/s12967-023-04269-2 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25257166 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Exploring the potential of microRNA as a diagnostic tool for gestational diabetesDuaa Ahmed Elhag (10227875)Souhaila Al Khodor (89983)Biological sciencesBiochemistry and cell biologyDiabetesOGTTPregnancy complicationsBMIMacrosomia<div><p>MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating host gene expression. Recent studies have indicated a role of miRNAs in the pathogenesis of gestational diabetes mellitus (GDM), a common pregnancy-related disorder characterized by impaired glucose metabolism. Aberrant expression of miRNAs has been observed in the placenta and/or maternal blood of GDM patients, suggesting their potential use as biomarkers for early diagnosis and prognosis. Additionally, several miRNAs have been shown to modulate key signaling pathways involved in glucose homeostasis, insulin sensitivity, and inflammation, providing insights into the pathophysiology of GDM. This review summarizes the current knowledge on the dynamics of miRNA in pregnancy, their role in GDM as well as their potential as diagnostic and therapeutic targets.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Journal of Translational Medicine<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-023-04269-2" target="_blank">https://dx.doi.org/10.1186/s12967-023-04269-2</a></p>2023-06-17T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-023-04269-2https://figshare.com/articles/journal_contribution/Exploring_the_potential_of_microRNA_as_a_diagnostic_tool_for_gestational_diabetes/25257166CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252571662023-06-17T03:00:00Z |
| spellingShingle | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes Duaa Ahmed Elhag (10227875) Biological sciences Biochemistry and cell biology Diabetes OGTT Pregnancy complications BMI Macrosomia |
| status_str | publishedVersion |
| title | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| title_full | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| title_fullStr | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| title_full_unstemmed | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| title_short | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| title_sort | Exploring the potential of microRNA as a diagnostic tool for gestational diabetes |
| topic | Biological sciences Biochemistry and cell biology Diabetes OGTT Pregnancy complications BMI Macrosomia |